Dissemination of <i>Acinetobacter baumannii</i> OXA-23 in old and new intensive care units without transfer of colonized patients

Moreira, Rafael Renato Brondani; Viana, Giselle Fukita; Moraes, Amanda Carina Coelho de; Bastos, Marina de Souza; Nishiyama, Sheila Alexandra Belini; Anjos, Márcia Maria dos; Cardoso, Celso Luíz; Tognim, Maria Cristina Bronharo

doi:10.1017/ice.2018.168

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…Persistent environmental contamination and HCW infection may be possible sources of carbapenem-resistance in both Klebsiella pneumoniae and Acinetobacter baumannii . 10 , 11 Several studies have shown the genetically similarity between strains isolated from the patients, HCWs, and the environment. 5 , 11 However, the origin of transmission between patient, HCW, and environment remains unknown, and thus should be elucidated in the future.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Surveillance and Sampling Reveal Carbapenem-Resistant Organism Spreading in Tertiary Hospitals in China

Zhang¹,

Yu²,

Chen³

et al. 2022

IDR

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Purpose Carbapenem-resistant organisms (CROs) have posed a great threat to antibiotic use and induce multi-drug resistance. Contamination of the hospital environment and infection of healthcare workers (HCWs) are reported as sources of nosocomial infections. Here, we performed a comprehensive environment sampling and timely epidemiological investigation during outbreaks to investigate the role of the environment and HCWs in CRO transmission. Patients and Methods We enrolled carbapenem-resistant organism outbreaks in ICU-1 of Huashan Hospital from January 2019 to March 2019, and ICU-2 located at west branch of Huashan Hospital from October 2019 to November 2019. Carbapenem-resistant Klebsiella pneumoniae (CRKP) and carbapenem-resistant Acinetobacter baumannii (CRAB) isolates were collected from the patients. We performed a real-time comprehensive environmental and HCW sampling in the two ICUs. Isolated strains from patients and the positive colonies from the screening were sent for whole-genome sequencing. Finally, phylogenetic trees were constructed. Results CRAB and CRKP outbreaks simultaneously occurred in ICU-1; the outbreak involved 13 patients. Meanwhile, the CRKP outbreak in ICU-2 included 11 patients. Twelve out of 146 environment and HCWs samples in ICU-1 were carbapenem-resistant bacteria, including six CRKP and six CRAB strains. For ICU-2, hospital surfaces and HCWs were negative for CRKP. Phylogenetic analyses showed that CRKP strains in ICU-1 were classified into two clades: Clade 1 and Clade 2, sharing a high similarity of isolates from the environment and HCWs. The same phenomenon was observed in CRAB. Conclusion A timely comprehensive sampling combined with genome-based investigation may aid in tracking the transmission route of and controlling the infections. The environment and HCWs could be contaminated during CRO transmission, which calls for strengthened prevention and control measures.

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Section: Discussionmentioning

confidence: 99%

Comprehensive Surveillance and Sampling Reveal Carbapenem-Resistant Organism Spreading in Tertiary Hospitals in China

Zhang¹,

Yu²,

Chen³

et al. 2022

IDR

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Genomic insights of Acinetobacter baumannii ST374 reveal wide and increasing resistome and virulome

Fedrigo

Xavier

Cerdeira

et al. 2022

Infection, Genetics and Evolution

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Outbreak of endemic carbapenem-resistant Acinetobacter baumannii in a coronavirus disease 2019 (COVID-19)–specific intensive care unit

Shinohara

Saalfeld

Martinez

et al. 2021

Infect. Control Hosp. Epidemiol.

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Dissemination of Acinetobacter baumannii OXA-23 in old and new intensive care units without transfer of colonized patients

Abstract: Molecular heterogeneity of Acinetobacter baumannii isolates during seasonal increase in prevalence.

Cited by 5 publications

References 9 publications

Comprehensive Surveillance and Sampling Reveal Carbapenem-Resistant Organism Spreading in Tertiary Hospitals in China

Comprehensive Surveillance and Sampling Reveal Carbapenem-Resistant Organism Spreading in Tertiary Hospitals in China

Genomic insights of Acinetobacter baumannii ST374 reveal wide and increasing resistome and virulome

Outbreak of endemic carbapenem-resistant Acinetobacter baumannii in a coronavirus disease 2019 (COVID-19)–specific intensive care unit

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