Dissemination of Case Studies on Ganotherapy

Rahman, Handono Fatkhur; Rahman, Shibley; Rahman, Arzia Pramadi; Rahman, K.

doi:10.1615/intjmedmushrooms.v7.i3.890

Cited by 10 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, more advanced research is needed to enhance both growth and secondary metabolites contents in this plant. Plant in vitro culture could represent an attractive option to multiply the plant [22], and also to produce plant biomass and secondary metabolites in controlled environment [23][24][25]. Light is an important abiotic elicitor that could also affect different physiological processes such as growth and development [26].…”

Section: Introductionmentioning

confidence: 99%

Interactive Effects of Wide-Spectrum Monochromatic Lights on Phytochemical Production, Antioxidant and Biological Activities of Solanum xanthocarpum Callus Cultures

et al. 2020

View full text Add to dashboard Cite

Solanum xanthocarpum is considered an important traditional medicinal herb because of its unique antioxidant, and anti-diabetic, anti-aging, and anti-inflammatory potential. Because of the over exploitation linked to its medicinal properties as well as destruction of its natural habitat, S. xanthocarpum is now becoming endangered and its supply is limited. Plant in vitro culture and elicitation are attractive alternative strategies to produce biomass and stimulate biosynthesis of medicinally important phytochemicals. Here, we investigated the potential influence of seven different monochromatic light treatments on biomass and secondary metabolites accumulation in callus culture of S. xanthocarpum as well as associated biological activities of the corresponding extracts. Among different light treatments, highest biomass accumulation was observed in white light-treated callus culture. Optimum accumulation of total flavonoid contents (TFC) and total phenolic contents (TPC) were observed in callus culture kept under continuous white and blue light respectively than control. Quantification of phytochemicals through HPLC revealed that optimum production of caffeic acid (0.57 ± 0.06 mg/g DW), methyl-caffeate (17.19 mg/g ± 1.79 DW), scopoletin (2.28 ± 0.13 mg/g DW), and esculetin (0.68 ± 0.07 mg/g DW) was observed under blue light callus cultures. Compared to the classic photoperiod condition, caffeic acid, methyl-caffeate, scopoletin, and esculetin were accumulated 1.7, 2.5, 1.1, and 1.09-folds higher, respectively. Moreover, high in vitro cell free antioxidant, anti-diabetic, anti-aging, and anti-inflammatory activities were closely associated with the production of these secondary metabolites. These results clearly showed the interest to apply multispectral light as elicitor of in vitro callus cultures S. xanthocarpum to promote the production of important phytochemicals, and allow us to propose this system as an alternative for the collection of this endangered species from the wild.

show abstract

Section: Introductionmentioning

confidence: 99%

Interactive Effects of Wide-Spectrum Monochromatic Lights on Phytochemical Production, Antioxidant and Biological Activities of Solanum xanthocarpum Callus Cultures

et al. 2020

View full text Add to dashboard Cite

show abstract

“…[30] also showed that concomitant ligand binding usually is only partially competitive and may include allosteric effects. However, when analysing ligand–ligand displacement interactions, the possibility of displacement of ligand from one site to another site should be taken into account [31, 40]. …”

Section: Discussionmentioning

confidence: 99%

The Investigation of the Binding of 6-Mercaptopurine to Site I on Human Serum Albumin

Sochacka

Baran

2012

Protein J

View full text Add to dashboard Cite

6-Mercaptopurine (6-MP) is one of a large series of purine analogues which has been found active against human leukemias. The equilibrium dialysis, circular dichroism (CD) and molecular docking were employed to study the binding of 6-MP to human serum albumin (HSA). The binding of 6-MP to HSA in the equilibrium dialysis experiment was detected by measuring the displacement of 6-MP by specific markers for site I on HSA, warfarin (RWF), phenylbutazone (PhB) and n-butyl p-aminobenzoate (ABE). It was shown, according to CD data, that binding of 6-MP to HSA leads to alteration of HSA secondary structure. Based on the findings from displacement experiment and molecular docking simulation it was found that 6-MP was located within binding cavity of subdomain IIA and the space occupied by site markers overlapped with that of 6-MP. Displacement of 6-MP by the RWF or PhB was not up the level expected for a competitive mechanism, therefore displacement of 6-MP was rather by non-cooperative than that the direct competition. Instead, in case of the interaction between ABE and 6-MP, when the little enhancement of the binding of ABE by 6-MP was found, the interaction could be via a positively cooperative mechanism.

show abstract

“…A large variety of oncolytic viral families have been investigated in various preclinical and clinical cancer studies [23]. These cover both single-stranded and double-stranded RNA and DNA viruses, including measles virus, vesicular stomatitis virus (VSV), reovirus, type 1 herpes simplex s (HSV-1), Newcastle disease virus (NDV), adenovirus, and poxviruses (vaccinia and myxoma viruses) [24][25][26][27][28][29][30][31][32][33]. As reviewed by Yang and colleagues, multiple viral and tumoral factors can impact OV therapy [24], but there are no general rules to predict the oncolytic efficiency of any OV with any target cancer, in part because the tumor microenvironment can vary widely, even within a single cancer patient.…”

Section: Oncolytic Viral Therapymentioning

confidence: 99%

Simultaneous Tumor and Stroma Targeting by Oncolytic Viruses

et al. 2020

View full text Add to dashboard Cite

Current cancer therapeutics often insufficiently eradicate malignant cells due to the surrounding dense tumor stroma. This multi-componential tissue consists of mainly cancer-associated fibroblasts, the (compact) extracellular matrix, tumor vasculature, and tumor-associated macrophages, which all exert crucial roles in maintaining a pro-tumoral niche. Their continuous complex interactions with tumor cells promote tumor progression and metastasis, emphasizing the challenges in tumor therapy development. Over the last decade, advances in oncolytic virotherapy have shown that oncolytic viruses (OVs) are a promising multi-faceted therapeutic platform for simultaneous tumor and stroma targeting. In addition to promoting tumor cell oncolysis and systemic anti-tumor immunity, accumulating data suggest that OVs can also directly target stromal components, facilitating OV replication and spread, as well as promoting anti-tumor activity. This review provides a comprehensive overview of the interactions between native and genetically modified OVs and the different targetable tumor stromal components, and outlines strategies to improve stroma targeting by OVs.

show abstract

Dissemination of Case Studies on Ganotherapy

Cited by 10 publications

References 0 publications

Interactive Effects of Wide-Spectrum Monochromatic Lights on Phytochemical Production, Antioxidant and Biological Activities of Solanum xanthocarpum Callus Cultures

Interactive Effects of Wide-Spectrum Monochromatic Lights on Phytochemical Production, Antioxidant and Biological Activities of Solanum xanthocarpum Callus Cultures

The Investigation of the Binding of 6-Mercaptopurine to Site I on Human Serum Albumin

Simultaneous Tumor and Stroma Targeting by Oncolytic Viruses

Contact Info

Product

Resources

About