Disseminated Trichosporonosis Caused by
            <i>Trichosporon loubieri</i>

Marty, Francisco M.; Barouch, Dan H.; Coakley, Eoin; Baden, Lindsey R.

doi:10.1128/jcm.41.11.5317-5320.2003

Cited by 52 publications

(29 citation statements)

References 28 publications

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“…He was successfully treated with a combination of amphotericin B and oral itraconazole. The second case, reported by Marty et al, describes a 56-year-old woman with pre-B-cell lymphoblastic leukemia who developed disseminated T. loubieri infection following induction chemotherapy (19). She was treated with oral fluconazole; however, she was unable to proceed with consolidation chemotherapy and soon died.…”

Section: Discussionmentioning

confidence: 99%

Trichosporon mycotoxinivorans , a Novel Respiratory Pathogen in Patients with Cystic Fibrosis

et al. 2009

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This report describes the molecular epidemiology, in vitro susceptibility, colonial and microscopic morphologies, and biochemical features of Trichosporon mycotoxinivorans, a newly recognized pathogen that appears to have a propensity for patients with cystic fibrosis. The index patient died with histologically documented Trichosporon pneumonia complicating cystic fibrosis. This is also the first report of disease caused by a Trichosporon species in a nontransplant patient with cystic fibrosis. As T. mycotoxinivorans has not previously been recognized as a respiratory pathogen, the significance of its recovery from sputum samples was not initially appreciated. Genetic analysis of archived clinical samples found three additional cases of T. mycotoxinivorans infection which had previously been identified as other members of the genus. An additional isolate of T. mycotoxinivorans was identified from a clinical sample on initial testing. Three of these four cases were also patients with cystic fibrosis. All isolates had MICs at 48 h of amphotericin B of >1 g/ml and of echinocandins of >16 g/ml, but they displayed various susceptibilities to the triazoles. In summary, Trichosporon mycotoxinivorans is a newly recognized human pathogen that is associated with cystic fibrosis.Trichosporon species are uncommon but potentially lifethreatening causes of localized and disseminated infections in immunocompromised patients. The most common species causing deep-seeded disseminated infection that has been recognized is Trichosporon asahii (11). Other species of Trichosporon are seldom reported as causes of deep-seeded infections. Herein, we describe the first case of human disease caused by Trichosporon mycotoxinivorans. Previously recognized as an industrial source for detoxification of mycotoxins, T. mycotoxinivorans has not been reported to cause disease in humans (20,28). Additional testing of archived isolates of the genus Trichosporon at the University of Texas San Antonio Fungus Testing Laboratory (FTL) revealed three additional cases, including two in patients with cystic fibrosis. These isolates had previously been classified under other species of Trichosporon on the basis of their biochemical profiles alone. A newly acquired sample in the FTL collection, from a cystic fibrosis patient, was also analyzed and identified as T. mycotoxinivorans. This report describes the molecular epidemiology, in vitro susceptibility, colonial and microscopic morphologies, and biochemical features of T. mycotoxinivorans, a newly recognized pathogen that appears to have a propensity for patients with cystic fibrosis. Index case.A 20-year-old male with a history of cystic fibrosis presented to the emergency department complaining of acute onset of dyspnea. He was found to have a right-sided pneumothorax. He was treated with supplemental oxygen, a chest tube was placed, and he was then admitted to the ward for supportive care. His recent medical history was notable for receiving home therapy with piperacillin-tazobactam and trimethoprim-su...

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Section: Discussionmentioning

confidence: 99%

Trichosporon mycotoxinivorans , a Novel Respiratory Pathogen in Patients with Cystic Fibrosis

et al. 2009

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“…Later, in 1988, Trichosporon pullulans (recently renamed Guehomyces pullulans) (34) infection was described (56), and in 2003 reports of invasive infections caused by T. loubieri began to appear in the literature (78,96). In 1992 the classification of members of the genus Trichosporon was substantially revised by Guého et al (46), and few years later a new classification was proposed by Sugita et al (113)(114)(115) on the basis of analysis of 26S rRNA sequences.…”

Section: Discussionmentioning

confidence: 99%

“…These included 287 cases classified under the broad heading of Trichosporon sp. infections ( (56,64,65,86,109), and 2 attributed to T. loubieri (78,96). The patient characteristics and geographic origins of the cases are summarized in Table 2.…”

Section: Methodsmentioning

confidence: 99%

Invasive Infections Caused byTrichosporonSpecies andGeotrichum capitatumin Patients with Hematological Malignancies: a Retrospective Multicenter Study from Italy and Review of the Literature

Girmenia¹,

Pagano

Martino³

et al. 2005

J Clin Microbiol

359

391

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Trichosporonosis is an uncommon but frequently fatal mycosis in immunocompromised patients 8 and 91.7%, respectively). Well over half of these were suffering from acute leukemia (68 and 84% of patients with Trichosporon sp. and G. capitatum infections, respectively). Crude mortality rates were 77% for Trichosporon spp. and 55.7% for G. capitatum. The optimal therapy for trichosporonosis has yet to be identified; however, in vitro experiences are providing encouraging evidence of the potential role of the new triazoles, in particular, voriconazole.

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“…The genus Trichosporon now comprises 36 species. The number of Trichosporon species causing disseminated disease is expanding; T. asteroides, T. loubieri, and T. dermatis have recently been shown to cause disseminated trichosporonosis (25,33,38,55). Trichosporon has been reported to be the most common cause of nonCandida yeast infections in patients with hematological malignancies, and the infections were associated with high mortality rates, despite antifungal therapy (59).…”

Section: Discussionmentioning

confidence: 99%

Molecular Identification and Susceptibility ofTrichosporonSpecies Isolated from Clinical Specimens in Qatar: Isolation ofTrichosporon dohaenseTaj-Aldeen, Meis & Boekhout sp. nov

et al. 2009

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Disseminated Trichosporonosis Caused by Trichosporon loubieri

Abstract: Trichosporonosis is an emerging invasive fungal infection in immunosuppressed patients; a case of disseminated infection caused by Trichosporon loubieri presented confirms its role as a human pathogen.

Cited by 52 publications

References 28 publications

Trichosporon mycotoxinivorans , a Novel Respiratory Pathogen in Patients with Cystic Fibrosis

Trichosporon mycotoxinivorans , a Novel Respiratory Pathogen in Patients with Cystic Fibrosis

Invasive Infections Caused byTrichosporonSpecies andGeotrichum capitatumin Patients with Hematological Malignancies: a Retrospective Multicenter Study from Italy and Review of the Literature

Molecular Identification and Susceptibility ofTrichosporonSpecies Isolated from Clinical Specimens in Qatar: Isolation ofTrichosporon dohaenseTaj-Aldeen, Meis & Boekhout sp. nov

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