Disseminated Superficial Actinic Porokeratosis: A Report of Eight Cases

Donald, G. F.; Hunter, G. A.

doi:10.1111/j.1440-0960.1968.tb01312.x

Cited by 13 publications

(4 citation statements)

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“…These parallel columns of parakeratosis histo logically resemble the 'cornoid lamellae' seen in porokeratosis of Mibelli [8] and disseminated superficial actinic porokeratosis [5]. However, the clinical findings do not correspond with these classical forms of centrifugally expand ing rings of porokeratosis, with the exception that the first change is reported [13] to be a horny papule, from which a plug falls out leaving a crater.…”

Section: Discussionmentioning

confidence: 64%

Punctate Porokeratotic Keratoderma

Ps¹

1973

Dermatology

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Extensive review of published reports of punctate keratoderma has revealed only one similar case to that reported in the present paper. This represents a diffuse involvement of the palms and soles with pinpoint keratotic plugs and pits which were proven to be parakeratotic columns histologically identical with the cornoid lamellae of porokeratotic conditions. The clinical and histologic features which set this form of keratoderma apart from other forms of punctate keratoderma are discussed.

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Section: Discussionmentioning

confidence: 64%

Punctate Porokeratotic Keratoderma

Ps¹

1973

Dermatology

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“…3 DSAP is an autosomal dominant condition with many kindreds carrying mutations in mevalonate pathway genes involved in cholesterol synthesis. 1,4,5 The prevalence of these mutations in sporadic cases is not known. Abnormal epidermal clones are thought to arise following ultraviolet radiation (UVR)-induced second-hit mutations in keratinocytes, which carry a germline mutation.…”

Section: Introductionmentioning

confidence: 99%

“…Disseminated superficial actinic porokeratosis (DSAP) is characterised by multiple skin lesions on the sun‐exposed limbs of adults 1 . As with other porokeratosis variants, lesions are annular with central atrophy and a fine peripheral keratotic rim, which corresponds to the histological cornoid lamella 2 .…”

Section: Introductionmentioning

confidence: 99%

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Topical simvastatin–cholesterol for disseminated superficial actinic porokeratosis: An open‐label, split‐body clinical trial

Byth

2021

Aust J Dermatology

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Background/Objectives: Disseminated superficial actinic porokeratosis (DSAP) is a porokeratosis variant that is cosmetically disfiguring and may be associated with squamous cell carcinoma. It is an autosomal dominant condition caused by germline mutations in mevalonate pathway genes involved in cholesterol synthesis. Lesions are precipitated by ultraviolet radiation-induced second-hit mutations. Modulation of this pathway by topical simvastatin-cholesterol may lead to improvement.Methods: This open-label, split-body clinical trial was carried out in 2020 at a metropolitan dermatology clinic. Eight patients contributing 13 limb pairs were recruited. Limbs within each pair were randomly allocated to 2% simvastatin/2% cholesterol cream applied twice daily or bland emollients. Lesion number, erythema, scale and patientreported disease activity were measured at baseline and 6 weeks. Data were analysed using Bayesian ordinal logistic regression. Odds ratios compare the odds of a higher score at 6 weeks in treated limbs with the odds in controls. Values less than one indicate improvement.Results: Patients had a median age of 65 years (interquartile range [IQR] 58 to 69 years). The median baseline DLQI was 5 (range 2-21). Odds ratios were 0.12 (95% credible interval [CI] 0.01 to 0.72) for lesion number, 0.25 (95% CI 0.05 to 0.79) for erythema score, 0.18 (95% CI 0.03 to 0.64) for scale score and 0.33 (95% CI 0.09 to 0.89) for patientreported disease activity. Conclusions:Topical simvastatin-cholesterol cream improved lesion number, erythema and scale on treated limbs compared with controls. Patientreported disease activity also improved. These findings warrant confirmation in blinded, vehiclecontrolled trials.

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Hyperkeratosis Lenticularis Perstans

Raffle¹

1969

Arch Dermatol

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Disseminated Superficial Actinic Porokeratosis: A Report of Eight Cases

Cited by 13 publications

References 0 publications

Punctate Porokeratotic Keratoderma

Punctate Porokeratotic Keratoderma

Topical simvastatin–cholesterol for disseminated superficial actinic porokeratosis: An open‐label, split‐body clinical trial

Hyperkeratosis Lenticularis Perstans

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