Disseminated Liposarcoma in a Dog

Wang, Fun-In; Liang, Sao-Ling; Eng, Hock‐Liew; Jeng, Chian-Ren; Pang, Victor Fei

doi:10.1177/104063870501700317

Cited by 22 publications

(35 citation statements)

References 12 publications

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“…Expression of vimentin, confirming the mesenchymal origin, and S-100 protein, suggestive of liposarcoma, have previously been described in canine liposarcoma (Wang and others 2005). The macroscopic findings suggested that the primary site of the liposarcoma in this case was the marrow of the right radius, but a periosteal liposarcoma must be considered as a differential diagnosis (Thompson and Pool 2002).…”

supporting

confidence: 69%

“…In human beings, a prevalence of 0.03 per cent among all bone neoplasms has been reported (Mirra and others 1989). It arises from adipocyte precursors in the marrow cavity and has been observed in the long bones or lumbar vertebrae of dogs (Brodey and Riser 1966, Davis and others 1974, Nielsen 1976, Wang and others 2005), the mandible of a ferret (Fuentealba and Blue-McLendon 1995) and the metacarpus of a kudu (Raubenheimer and others 1990). Histologically, liposarcomas of bone closely resemble their soft tissue counterpart (Brodey and Riser 1966, Thompson and Pool 2002).…”

mentioning

confidence: 99%

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Metastasising liposarcoma of bone in a young dog

Frase¹,

Freytag

Baumgartner³

et al. 2009

Veterinary Record

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Sagittal section of the distal radius and carpus of a dog with liposarcoma. Tumour tissue arising from the marrow cavity of the distal radius (*) penetrates the cortical bone and infiltrates the adjacent soft tissues. There is periosteal new bone formation proximal to the tumour (arrow) FIG 2: Section of a tumour from the bone marrow of the dog, consisting of sheets of vacuolated cells with round to oval vesicular nuclei: there are numerous mitotic figures (arrows). Haematoxylin and eosin. Bar=50 µm

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supporting

confidence: 69%

mentioning

confidence: 99%

Metastasising liposarcoma of bone in a young dog

Frase¹,

Freytag

Baumgartner³

et al. 2009

Veterinary Record

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“…The microscopical features of tumor cells together with Oil Red O positivevacuoles and Alcian blue positive-stroma verified the first case of the myxoid variant of liposarcoma in a cat. Vimentin and S-100 immunolabeling are suggestive of liposarcoma (11). Our case showed only vimentin immunolabeling, but was negative for S-100.…”

Section: Bir Kedide Miksoid Liposarkommentioning

confidence: 79%

Short Communication / Kısa Bilimsel Çalışma: Myxoid liposarcoma in a cat

Kabak¹,

Yardımcı²,

Okur-Gümüşova³

et al. 2011

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:In the study, a myxoid liposarcoma in the proximal region of the left humerus of a 15-year-old male, shorthair cat was described. Left arm along with scapula was amputated. The cut section of tumor was tan to white with soft multilobulated mass which contained hemorrhagic and necrotic foci as well as mucuous composition. Microscopically, the tumor was composed of roundto-polygonal cells. The cells had numerous round, variable-sized, well-defined, intracytoplasmic vacuoles. The lipid droplets in the cytoplasmic vacuoles of the tumor cells was showed with Oil Red O staining. A myxoid extracellular substance remind of mucin was stained by Alcian blue staining (pH = 2,5). Tumor cells were strongly positive for vimentin, but negative for pancytokeratin and S-100. A polymerase chain reaction (PCR) assay from samples showed no evidence of feline leukemia virus (FeLV) / feline sarcomavirus (FeSV) or feline immunodeficiency virus (FIV) deoksiribonucleic acid (DNA). This case describes a first report of myxoid liposarcoma in a cat.

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“…Liposarcomas are rare neoplasms in domestic animals, but have been reported to occur in many species [1,4,5,[7][8][9][11][12][13]. In Herpestidae animals, the neoplasms have seldom been reported and, to our knowledge, their occurrence has not been documented for meerkats so far [10].…”

mentioning

confidence: 83%

Pleomorphic Liposarcoma of the Intrathoracic Cavity in a Meerkat (Suricata suricatta)

Aihara

Une

2009

J. Vet. Med. Sci.

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ABSTRACT. Postmortem examination of a meerkat which had been captive for eight years in zoo, revealed multinodular white masses filling the thoracic cavity with systemic metastasis. Microscopically, the neoplastic cells were polygonal to spindle-shaped and had eosinophilic cytoplasm often with variable numbers of small lipid droplets. Immunohistochemically, the neoplastic cells were intensely positive for vimentin and occasionally weakly positive for S-100. Ultrastructurally, several lipid droplets without limiting membranes were observed in the cytoplasm. Based on the findings above, the tumor was diagnosed as a pleomorphic liposarcoma arising from the thoracic cavity. To date, neoplasms have seldom been reported in Herpestidae animals. To the authors' knowledge, this is the first reported case of liposarcoma in a meerkat. KEY WORDS: liposarcoma, meerkat, systemic metastasis, thoracic cavity.J. Vet. Med. Sci. 71(5): 685-688, 2009 Liposarcomas are rare neoplasms in domestic animals, but have been reported to occur in many species [1,4,5,[7][8][9][11][12][13]. In Herpestidae animals, the neoplasms have seldom been reported and, to our knowledge, their occurrence has not been documented for meerkats so far [10]. Here we report the first case of pleomorphic liposarcoma in a meerkat, which developed in the thoracic cavity with systemic metastasis.A female meerkat which had been in captivity for eight years in zoo was unresponsive to steroid therapy and died after 3 months history of progressive depression, anorexia, and respiratory distress. Postmortem examination revealed multinodular white masses filling the thoracic cavity (Fig. 1). The mass surrounded the heart and displaced the diaphragm toward the abdominal cavity (Fig. 2). The cut surface of the tumor was white in color and lobulated. The lungs were displaced dorsally and a number of white nodules were scattered on the surface. Numerous white nodules were found in the liver. Small neoplastic nodules were also present on the thoracic wall, omentum, mesentery, and surface of the abdominal organs.For light microscopic examination, sections of the tumor and major organs were stained with hematoxylin and eosin (HE), periodic acid-Schiff (PAS), PAS with diastase digestion, and silver impregnation. Oil red O staining was performed on frozen sections to demonstrate fat droplets in the neoplastic cells.Immunohistochemical staining was performed using primary mouse monoclonal antibodies to vimentin (vimentin, v9; Dakocytomation Denmark A/S, Glostrup, Denmark), S-100 protein (beta-chain specific) (S-100; JIMRO, Takasaki, Japan), neuron specific enolase (NSE, 1G4; Zymed Laboratories, San Francisco, U.S.A.), human desmin (desmin, D33; Dakocytomation Denmark A/S), and human smooth muscle actin (-SMA, 1A4; Dakocytomation Denmark A/ S). Microwave antigen retrieval was performed at 90C for 9 min (vimentin, S-100, NSE, desmin). The tissues were incubated with primary antibodies at 4C overnight. For secondary antibody reaction, tissues were incubated with mouse or rabbit...

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Disseminated Liposarcoma in a Dog

Cited by 22 publications

References 12 publications

Metastasising liposarcoma of bone in a young dog

Metastasising liposarcoma of bone in a young dog

Short Communication / Kısa Bilimsel Çalışma: Myxoid liposarcoma in a cat

Pleomorphic Liposarcoma of the Intrathoracic Cavity in a Meerkat (Suricata suricatta)

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