Disseminated cryptococcosis with cutaneous lesions complicating steroid therapy for Behçet's disease*

Carbia, Sergio; Chain, Myriam; Acuña, Karina; Dei-Cas, Ignacio; Glorio, Roberto; Malah, Verónica; Juárez, María; Woscoff, Alberto

doi:10.1046/j.1365-4362.2003.01758.x

Cited by 8 publications

(4 citation statements)

References 7 publications

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“…Since the cumulative analysis of pulmonary BD [11], more than 30 papers about BD-related pulmonary problems have been published [16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46]. Most of these cases were diagnosed as having PAA and only 1 patient had small-sized vasculitis [34].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Involvement in Behçet’s Disease

Uzun

Erkan

Akpolat³

et al. 2007

Respiration

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Background: Behçet’s disease (BD) is a multisystem vasculitis and pulmonary involvement in BD is reported to indicate poor prognosis and high mortality. Objectives: The aims of this study were to report on patients with pulmonary involvement and to discuss pulmonary artery thrombus and small-sized vasculitis associated with BD, with respect to previously published cases. Methods: Fifteen patients with BD and pulmonary involvement were included in this study. Massive hemoptysis was observed in all patients having pulmonary artery aneurysm (PAA). Results: Eleven patients had macroscopic pulmonary vascular disease (2 PAA, 3 PAA and thrombi and 6 only thrombi) and 3 patients had microscopic pulmonary vascular disease. The remaining patient had pulmonary cryptococcosis. Conclusions: Data regarding treatment and outcomes of patients having BD-related pulmonary emboli/infarct and small-sized vasculitis are limited. Pulmonary vasculitis affects different levels of the pulmonary artery in BD and should be classified as macroscopic and microscopic vascular disease. ‘Pulmonary artery thrombosis’ should be used instead of ‘pulmonary emboli’. Spiral CT angiography is the best radiological tool for evaluation of pulmonary problems in BD. Treatment of vasculitis should be based on the type of vascular disease and may vary among different types of vascular disease. Anticoagulation can be used in patients with microscopic vascular disease and nonaneurysmal macroscopic vascular disease. More studies are needed to clarify this issue.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Involvement in Behçet’s Disease

Uzun

Erkan

Akpolat³

et al. 2007

Respiration

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“…Although no systematic review regarding this issue has been published, several reports [59][60][61][62][63][64][65][66][67][68][69][70] have described important opportunistic infections secondary to bacteria, fungal, protozoa and viral agents. Although no systematic review regarding this issue has been published, several reports [59][60][61][62][63][64][65][66][67][68][69][70] have described important opportunistic infections secondary to bacteria, fungal, protozoa and viral agents.…”

Section: Infectious Complications Of Immunosuppressive Drugs In Bdmentioning

confidence: 99%

“…Although no systematic review regarding this issue has been published, several reports [59][60][61][62][63][64][65][66][67][68][69][70] have described important opportunistic infections secondary to bacteria, fungal, protozoa and viral agents. A wide spectrum of microbiologic agents 63,[74][75][76] can complicate the use of steroids, including gram-negative or -positive bacteria, 67,68 mycobacteria, fungi 69 and virus. Corticosteroid actions [71][72][73] result in a qualitative defect of phagocytic function, neutropenia, lymphocytopenia, suppression of normal delayed hypersensitivity reactions and, in high doses, defective humoral immunity.…”

Section: Infectious Complications Of Immunosuppressive Drugs In Bdmentioning

confidence: 99%

Infection and Behçet Disease

Correia

Campar

Ferrão

et al. 2015

Infection and Autoimmunity

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“…Acquired immune deficiency syndrome (AIDS) is the most frequent predisposing factor, but it also occurs in other immunosuppressed individuals. The usual risk factors for HIV‐negative cutaneous cryptococcosis are immunosuppressive therapy for cancer or organ transplantation, sarcoidosis, Hodgkin's disease, systemic lupus erythematosus, and long‐term treatment with corticosteroids (1, 2).…”

Section: To the Editormentioning

confidence: 99%

Localized Cutaneous Cryptococcosis in a Patient with Chronic Myeloproliferative Disease

Ebara

Kobayashi

Asada

et al. 2005

The Journal of Dermatology

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We report a 60-year-old Japanese woman who came to our clinic in October of 2003. Ten days before presentation, a reddish, firm, painless nodule had appeared on her left thigh. She had been treated with oral prednisolone 10 mg per day for 9 months, and oral hydroxycarbamide for two years, for chronic myeloproliferative disease, a pre-leukemic state similar to chronic myeloid leukemia. In 2002, she developed hepatic cancer from liver cirrhosis caused by hepatitis B and/or C viruses.Physical examination at presentation: Her temperature, pulse and blood pressure were normal. Laboratory studies showed blast cells in the blood profile, and elevations of AST, ALT, and AFP, which were associated with the myeloproliferating disease and hepatic cancer. Serology for human immunodeficiency virus (HIV) was negative. The CD4 count was 239/m 3 , and the CD8 count was 329/m 3 . Chest X-ray showed no nodules. Cerebrospinal fluid (CSF) was not examined. A reddish, firm nodule measuring approximately 15 mm in diameter was found on her left inner thigh (Fig. 1). No local lymphadenopathy was present.

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Disseminated cryptococcosis with cutaneous lesions complicating steroid therapy for Behçet's disease*

Cited by 8 publications

References 7 publications

Pulmonary Involvement in Behçet’s Disease

Pulmonary Involvement in Behçet’s Disease

Infection and Behçet Disease

Localized Cutaneous Cryptococcosis in a Patient with Chronic Myeloproliferative Disease

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