A 47-year-old woman presented with multiple bluish subcutaneous nodules on the trunk and upper extremities. The histological diagnosis of a subcutaneous nodule was cavernous hemangioma. Multiple cavernous hemangiomas were also found in her cerebrum, cerebellum, and medulla oblongata on magnetic resonance imaging examination. We did not detect any mutations in the two loci of the TIE2 gene that have been reported in familial venous malformations.
We report a 60-year-old Japanese woman who came to our clinic in October of 2003. Ten days before presentation, a reddish, firm, painless nodule had appeared on her left thigh. She had been treated with oral prednisolone 10 mg per day for 9 months, and oral hydroxycarbamide for two years, for chronic myeloproliferative disease, a pre-leukemic state similar to chronic myeloid leukemia. In 2002, she developed hepatic cancer from liver cirrhosis caused by hepatitis B and/or C viruses.Physical examination at presentation: Her temperature, pulse and blood pressure were normal. Laboratory studies showed blast cells in the blood profile, and elevations of AST, ALT, and AFP, which were associated with the myeloproliferating disease and hepatic cancer. Serology for human immunodeficiency virus (HIV) was negative. The CD4 count was 239/m 3 , and the CD8 count was 329/m 3 . Chest X-ray showed no nodules. Cerebrospinal fluid (CSF) was not examined. A reddish, firm nodule measuring approximately 15 mm in diameter was found on her left inner thigh (Fig. 1). No local lymphadenopathy was present.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.