Dissection of the antibacterial mechanism of zinc oxide nanoparticles with manipulable nanoscale morphologies

Zhu, Xinyi; Wang, Jun; Cai, Ling; Wu, Yuan; Ji, Minghui; Jiang, Huijun; Chen, Jin

doi:10.1016/j.jhazmat.2022.128436

Cited by 72 publications

(42 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, despite their known properties, the molecular mechanisms behind their antimicrobial activity are not fully determined or understood. In an attempt to answer this question, in the last decade, a vast number of studies have been conducted [ 205 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 235 , 236 , 237 , 238 , 239 , 240 , 241 , 242 ]. In these studies, mostly AgNPs (72% of studies) but also other metal and metal oxide NPs, such as zinc oxide nanoparticles (ZnONPs) (10%) and copper nanoparticles (CuNPs) (5%)—and also gold, iron oxide, magnesium oxide, manganese and titanium nanoparticles (AuNPs, FeONPs, MgONPs, Mn and TiO 2 NPs) (3% each)—were used against Gram-negative (77%) and Gram-positive (38%) bacteria and against fungi (5%).…”

Section: Antimicrobial Activity Of Metal Nanoparticlesmentioning

confidence: 99%

“…Despite some disagreement [ 205 , 206 ], most studies determined that the antimicrobial mechanism of MNPs involves, at some point, the formation of reactive oxygen species (ROS) [ 207 , 208 , 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 ] and intracellular content leakage due to cell membrane disruption [ 208 , 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 232 ]. However, the reasons behind these occurrences and the order in which they occur differ across studies.…”

Section: Antimicrobial Activity Of Metal Nanoparticlesmentioning

confidence: 99%

See 1 more Smart Citation

Biosynthesis of Metal and Metal Oxide Nanoparticles Using Microbial Cultures: Mechanisms, Antimicrobial Activity and Applications to Cultural Heritage

et al. 2023

View full text Add to dashboard Cite

Nanoparticles (1 to 100 nm) have unique physical and chemical properties, which makes them suitable for application in a vast range of scientific and technological fields. In particular, metal nanoparticle (MNPs) research has been showing promising antimicrobial activities, paving the way for new applications. However, despite some research into their antimicrobial potential, the antimicrobial mechanisms are still not well determined. Nanoparticles’ biosynthesis, using plant extracts or microorganisms, has shown promising results as green alternatives to chemical synthesis; however, the knowledge regarding the mechanisms behind it is neither abundant nor consensual. In this review, findings from studies on the antimicrobial and biosynthesis mechanisms of MNPs were compiled and evidence-based mechanisms proposed. The first revealed the importance of enzymatic disturbance by internalized metal ions, while the second illustrated the role of reducing and negatively charged molecules. Additionally, the main results from recent studies (2018–2022) on the biosynthesis of MNPs using microorganisms were summarized and analyzed, evidencing a prevalence of research on silver nanoparticles synthesized using bacteria aiming toward testing their antimicrobial potential. Finally, a synopsis of studies on MNPs applied to cultural heritage materials showed potential for their future use in preservation.

show abstract

Section: Antimicrobial Activity Of Metal Nanoparticlesmentioning

confidence: 99%

Section: Antimicrobial Activity Of Metal Nanoparticlesmentioning

confidence: 99%

Biosynthesis of Metal and Metal Oxide Nanoparticles Using Microbial Cultures: Mechanisms, Antimicrobial Activity and Applications to Cultural Heritage

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Frankfurter-type sausages [63] Another approach often adopted in meat preservation to minimize microbial resistance involves inorganic nanoparticles. The advantages of these antibacterial reagents (e.g., metal oxide) over organic materials are low biotoxicity and greater stability at high temperatures and pressures [83]. Materials commonly used to produce inorganic nanoparticles include silver, titanium, gold, and zinc, which are four oxide metals.…”

Section: Nmmentioning

confidence: 99%

Recent Developments and Applications of Nanosystems in the Preservation of Meat and Meat Products

Ulloa-Saavedra

García-Betanzos

Zambrano-Zaragoza

et al. 2022

Foods

View full text Add to dashboard Cite

Due to their high water, lipid, and protein content, meat and meat products are highly perishable. The principal spoilage mechanisms involved are protein and lipid oxidation and deterioration caused by microbial growth. Therefore, efforts are ongoing to ensure food safety and increase shelf life. The development of low-cost, innovative, eco-friendly approaches, such as nanotechnology, using non-toxic, inexpensive, FDA-approved ingredients is reducing the incorporation of chemical additives while enhancing effectiveness and functionality. This review focuses on advances in the incorporation of natural additives that increase the shelf life of meat and meat products through the application of nanosystems. The main solvent-free preparation methods are reviewed, including those that involve mixing organic–inorganic or organic–organic compounds with such natural substances as essential oils and plant extracts. The performance of these additives is analyzed in terms of their antioxidant effect when applied directly to meat as edible coatings or marinades, and during manufacturing processes. The review concludes that nanotechnology represents an excellent option for the efficient design of new meat products with enhanced characteristics.

show abstract

“…[6] The antibacterial effect of Zn is mainly reflected in the form of zinc oxide (ZnO). [7][8][9] ZnO has shown excellent antibacterial performance against Gram-negative and Gram-positive bacteria, and it has certain selective preference for resistance to eukaryotes and prokaryotes. Cu is one of the essential trace elements for human body, and as a major antibacterial element, compared with Fe and Zn, it is more difficult for bacteria to form protective biofilm on the surface of Cu, and Cu can inhibit or kill a variety of pathogenic microorganisms such as bacteria, yeast, viruses, etc.…”

Section: Introductionmentioning

confidence: 99%

Copper‐Based Nanoparticles as Antibacterial Agents

Liao

et al. 2022

Eur J Inorg Chem

View full text Add to dashboard Cite

Over the past few decades, the resistance of different pathogenic bacteria to various antibiotics has gradually increased. In order to solve the problems of this modern era, metal nanoparticles have attracted more attention than ever. Copper has been recognized as a non-toxic, safe inorganic material and cheap antibacterial or antifungal agent, showing potential antibacterial effect in many biomedical fields. This interest has accelerated the generation of many novel methods for the synthesis of copper-based nanoparticles. Due to the nontoxicity and safety requirements of antibacterial agents, the recent green synthesis of copper-based nanoparticles is gradually replacing the traditional methods. In addition, the antibacterial mechanism of copper-based nanoparticles has provoked great curiosity. This review summarizes the synthetic methods, the possible antibacterial mechanisms and applications of copper-based nanoparticles. Additionally, the application prospects of copper-based nanoparticle antibacterial agent in biomedical applications and clinical field have been described and discussed.

show abstract

Dissection of the antibacterial mechanism of zinc oxide nanoparticles with manipulable nanoscale morphologies

Cited by 72 publications

References 73 publications

Biosynthesis of Metal and Metal Oxide Nanoparticles Using Microbial Cultures: Mechanisms, Antimicrobial Activity and Applications to Cultural Heritage

Biosynthesis of Metal and Metal Oxide Nanoparticles Using Microbial Cultures: Mechanisms, Antimicrobial Activity and Applications to Cultural Heritage

Recent Developments and Applications of Nanosystems in the Preservation of Meat and Meat Products

Copper‐Based Nanoparticles as Antibacterial Agents

Contact Info

Product

Resources

About