Dissection of Moringa oleifera leaf metabolome in context of its different extracts, origin and in relationship to its biological effects as analysed using molecular networking and chemometrics

Shakour, Zeinab T. Abdel; El-Akad, Radwa H.; Elshamy, Abdelsamed I.; Gendy, Abd El‐Nasser G. El; Wessjohann, Ludger A.; Farag, Mohamed A.

doi:10.1016/j.foodchem.2022.133948

Cited by 26 publications

(34 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As mentioned above, this can be explained by a higher radical scavenging activity or a faster oxidative degradation. The extent to which carotenoids intervene in the revolutionary chain process depends on their chemical structure (end groups, chain length, and number and position of methyl groups) ( Shakour et al, 2023 ).…”

Section: Natural Antioxidantsmentioning

confidence: 99%

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

2023

View full text Add to dashboard Cite

Section: Natural Antioxidantsmentioning

confidence: 99%

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

2023

View full text Add to dashboard Cite

“…Secondary metabolites are the main contributors to the biological potentialities of the plant extracts [ 49 ]. Polyphenolic compounds, including flavonoids and phenolic and organic acids, were documented as the most active compounds against free radicals and thus inflammation [ 49 , 50 ]. Current findings reveal that flavonoids were the main components of CLEE, encompassing flavones, flavonols, aurones, and flavanonequinones.…”

Section: Discussionmentioning

confidence: 99%

Chemical Profile of Cyperus laevigatus and Its Protective Effects against Thioacetamide-Induced Hepatorenal Toxicity in Rats

Ayoub

Mohamed

Elghonemy³

et al. 2022

Molecules

Self Cite

View full text Add to dashboard Cite

Cyperus species represent a group of cosmopolitan plants used in folk medicine to treat several diseases. In the current study, the phytochemical profile of Cyperus laevigatus ethanolic extract (CLEE) was assessed using UPLC-QTOF–MS/MS. The protective effect of CLEE at 50 and 100 mg /kg body weight (b.w.) was evaluated on hepatorenal injuries induced by thioacetamide (100 mg/kg) via investigation of the extract’s effects on oxidative stress, inflammatory markers and histopathological changes in the liver and kidney. UPLC-QTOF–MS/MS analysis of CLEE resulted in the identification of 94 compounds, including organic and phenolic acids, flavones, aurones, and fatty acids. CLEE improved the antioxidant status in the liver and kidney, as manifested by enhancement of reduced glutathione (GSH) and coenzyme Q10 (CoQ10), in addition to the reduction in malondialdehyde (MDA), nitric oxide (NO), and 8-hydroxy-2′-deoxyguanosine (8OHdG). Moreover, CLEE positively affected oxidative stress parameters in plasma and thwarted the depletion of hepatorenal ATP content by thioacetamide (TAA). Furthermore, treatment of rats with CLEE alleviated the significant increase in plasma liver enzymes, kidney function parameters, and inflammatory markers. The protective effect of CLEE was confirmed by a histopathological study of the liver and kidney. Our results proposed that CLEE may reduce TAA-hepatorenal toxicity via its antioxidant and anti-inflammatory properties suppressing oxidative stress.

show abstract

“…Both polar and apolar leaf and seed extracts contain several relevant compounds belonging to the classes of fatty acids, alkanes, amino acids, glucosinolates, polyphenols, which make M. oleifera a very interesting plant from a nutritional and a pharmacological point of view [5,7]. Thus, several pharmacological properties have been investigated and attributed to the seed and leaf extracts, e.g., cardiovascular activity [8], anti-inflammatory activity [9], antihypertensive activity [10], radical scavenging and antioxidant activity [11,12], anticancer activity [13,14], hepatoprotective and nutraceutical activity [15,16], anti-allergic activity, antimicrobial [17] and antiviral activity [18].…”

Section: Nmr Analysis Of M Oleifera Polar Extractsmentioning

confidence: 99%

“…Today, M. oleifera is used for many purposes such as in human diet and livestock feeding, thanks to the excellent nutritional aspects (high quantities of vitamins, proteins, and amino acids) [2]; in medicine, thanks to the properties mentioned earlier; as fuel wood; for soil conservation (used as green manure) and water purification (the seeds are used for clarification of water) [6]. Both polar and apolar leaf and seed extracts contain several relevant compounds belonging to the classes of fatty acids, alkanes, amino acids, glucosinolates, polyphenols, which make M. oleifera a very interesting plant from a nutritional and a pharmacological point of view [5,7]. Thus, several pharmacological properties have been investigated and attributed to the seed and leaf extracts, e.g., cardiovascular activity [8], anti-inflammatory activity [9], antihypertensive activity [10], radical scavenging and antioxidant activity [11,12], anticancer activity [13,14], hepatoprotective and nutraceutical activity [15,16], anti-allergic activity, antimicrobial [17] and antiviral activity [18].…”

Section: Introductionmentioning

confidence: 99%

Chemical Analysis and Antimicrobial Activity of Moringa oleifera Lam. Leaves and Seeds

et al. 2022

View full text Add to dashboard Cite

Moringa oleifera is a traditional food crop widespread in Asiatic, African, and South American continents. The plant, able to grow in harsh conditions, shows a high nutritional value and medicinal potential evidencing cardioprotective, anti-inflammatory, antioxidant, and antimicrobial properties. The purpose of this study was the phytochemical analysis of M. oleifera and the identification of the antimicrobial compounds by combining a chemical approach with in vitro tests. The metabolite profile of M. oleifera polar and apolar extracts of leaves and seeds were investigated by using Nuclear Magnetic Resonance spectroscopy and Gas Chromatography-Mass Spectrometry. The antimicrobial activity of all of the obtained extract was evaluated against four bacterial pathogens (Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa and Salmonella enterica). The chemical analysis provided a wide set of metabolites that were identified and quantified. Moreover, apolar extracts from seeds showed a significant concentration-dependent antimicrobial activity against S. aureus and S. epidermidis, (4 mg/mL reduced the viability up to 50%) that was associated to the content of specific fatty acids. Our results remarked the advantages of an integrated approach for the identification of plant metabolites and its use in association with biological tests to recognize the compounds responsible for bioactivity without compounds purification.

show abstract

Dissection of Moringa oleifera leaf metabolome in context of its different extracts, origin and in relationship to its biological effects as analysed using molecular networking and chemometrics

Cited by 26 publications

References 50 publications

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

Chemical Profile of Cyperus laevigatus and Its Protective Effects against Thioacetamide-Induced Hepatorenal Toxicity in Rats

Chemical Analysis and Antimicrobial Activity of Moringa oleifera Lam. Leaves and Seeds

Contact Info

Product

Resources

About