Dissecting the regulatory network of transcription factors in T cell phenotype/functioning during GVHD and GVT

Abstract

Transcription factors play a major role in regulation and orchestration of immune responses. The immunological context of the response can alter the regulatory networks required for proper functioning. While these networks have been well-studied in canonical immune contexts like infection, the transcription factor landscape during alloactivation remains unclear. This review addresses how transcription factors contribute to the functioning of mature alloactivated T cells. This review will also examine how these factors form a regulatory network to control alloresponses, with a focus specifically on those factors expressed by and controlling activity of T cells of the various subsets involved in graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) responses.

Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation

“…In the setting of allogeneic transplantation from a haploidentical donor, the first platform for GvHD prevention was based on profound nonselective T depletion, where all T cells were removed from the hematopoietic stem cell (HSC) inoculum and which, however, compromised the immunological reconstitution and the same GvL effect [4,5]. Since then, different approaches have been proposed, but the separation between GvHD and GvL still remains an open challenge [6,7]. In this review, we will summarize the more recent cellular strategies aimed at separating GvHD from GvL by using selective T cell targeting for patients undergoing stem cell transplantation for hematological malignancies.…”

Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation

“…In the setting of allogeneic transplantation from a haploidentical donor, the first platform for GvHD prevention was based on the profound non-selective T depletion, where all T cells were removed from the hematopoietic stem cell (HSC) inoculum and which, however, compromised the immunological reconstitution and the same GvL effect [4,5]. Since then, different approaches have been proposed, but the separation between GvHD and GvL still remains an open challenge [6,7]. In this review we will summarize the more recent cellular strategies aimed at separating GvHD from GvL by using selective T cell targeting for patients undergoing stem cell transplantation for haematological malignancies.…”