Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation
Mauro Di Ianni,
Carmine Liberatore,
Nicole Santoro
et al.
Abstract:GvHD still remains, despite the continuous improvement of transplantation platforms, a fearful complication of transplantation from allogeneic donors. Being able to separate GvHD from GvL represents the greatest challenge in the allogeneic transplant setting. This may be possible through continuous improvement of cell therapy techniques. In this review, current cell therapies are taken into consideration, which are based on the use of TCR alpha/beta depletion, CD45RA depletion, T regulatory cell enrichment, NK… Show more
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