Dissecting the Potential of Selenoproteins Extracted from Selenium-Enriched Rice on Physiological, Biochemical and Anti-Ageing Effects In Vivo

Zhao, Rui; Farooq, Muhammad Umer; Zhang, Guo; Tang, Zhichen; Zheng, Ting; Yang, Shuxu; Hussain, Sajad; Liang, Yuanke; Ye, Xiaoying; Jia, Xiaomei; Zhu, Jianqing

doi:10.1007/s12011-019-01896-z

Cited by 35 publications

(24 citation statements)

References 32 publications

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“…Therefore, numerous researches have shown that treatment with antioxidants could delay the cellular senescence [32]. Zeng et al [33] reported that Se-enriched rice could enhance the activity of antioxidant enzymes and prevent the formation of oxidative products. In this work, the MDA and protein carbonyl levels of the mice treated with SCML were decreased, indicating that SCML could inhibit products of lipid and protein peroxidation, and stabilize the cell membrane structure.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice

Xie

Jiang

Yao

et al. 2020

BMC Complement Med Ther

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Background: The purpose of this study was to assess the antioxidative activity of selenium-enriched Chrysomyia Megacephala (Fabricius) (C. megacephala) larvae powder (SCML) and its impact on the diversity and structure of intestinal microflora in a mouse model of D-galactose (D-gal)-induced oxidative damage. Methods: Sixty male ICR mice were equally randomized to a normal control (NC) group, a model group, a positive group, a low-dose SCML (L-SCML) group, a mid-dose SCML (M-SCML) group, and a high-dose SCML (H-SCML) group. Animals in NC and model groups received water, animals in the positive group received 40 mg/Kg vitamin E (VE), and those in the three SCML groups received SCML which include 300, 1000 and 3000 μg/Kg selenium (Se) respectively. An oxidative damage model induced by subcutaneous injection of D-gal for 6 weeks via the neck was established. Serum oxidative stress levels and tissue appearance were evaluated. Tissues oxidative stress levels were detected by commercially available kit. Nuclear erythroid 2-related factor (Nrf2) and gut microbiota were determined by western blot and high throughput sequencing 16S rRNA gene respectively. Results: An oxidative damage model was established successfully as represented by a significant elevation of malondialdehyde (MDA) and protein carbonylation, and inhibition of the antioxidants including superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC) and glutathione (GSH). It was found that oxidative damage and histological alterations were attenuated, the expression of Kelch-like ECH-associated protein (Keap1) was decreased, and the expression of Nrf2 and hemeoxygenase-1 (HO-1) was increased after SCML treatment. In addition, significant changes were observed in the gut microbiota, including Proteobacteria and the ratio of Bacteroidetes to Firmicutes at the phylum level, as well as Helicobacter, Clostridium and Lactobacillus at the genus level.

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Section: Discussionmentioning

confidence: 99%

Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice

Xie

Jiang

Yao

et al. 2020

BMC Complement Med Ther

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“…Unlike brown rice, which has outer bran and germ portions containing fiber, vitamins, and minerals, white rice loses a large amount of these components during refining processes (6)(7)(8). On the other hand, white rice is an important source of Se in China, and many prepackaged rice products in the market have claims on the label related to selenium content, such as "selenium-rich rice" (9). This has been motivated by low Se status in the population, which has been associated with an increased risk of overall mortality, poor immune function, and cognitive decline (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Risk–Benefit Assessment of Consumption of Rice for Adult Men in China

Fang

Zhang²,

Zhang

et al. 2021

Front. Nutr.

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Objective: To evaluate the health impact of current and alternative patterns of rice consumption in Chinese adult men (40–79 years of age).Methods: We applied a risk–benefit assessment (RBA) model that took into account the health effects of selenium (Se), cadmium (Cd), and inorganic arsenic (i-As). The health effects included the prevention of prostate cancer associated with exposure to Se, and an increased risk of lung, bladder, and skin cancer for i-As and chronic kidney disease (CKD) for Cd. We defined the baseline scenario (BS) as the current individual mean daily consumption of rice in the population of interest and two alternative scenarios (AS): AS1 = 50 g/day and AS2 = 200 g/day. We estimated the health impact for different age groups in terms of change in Disability-Adjusted Life Years (ΔDALY).Results: The BS of rice consumption was 71.5–105.4 g/day in different age groups of adult men in China. We estimated that for AS1, the mean ΔDALY was −2.76 to 46.2/100,000 adult men of 40–79 years old. For AS2, the mean ΔDALY was 41.3 to 130.8/100,000 individuals in this population group.Conclusion: Our results showed that, based on associated exposure to selenium, cadmium, and i-As in rice, the current consumption of rice does not pose a risk to adult men in China. Also, a lower (50 g/day) or higher (200 g/day) rice consumption will not bring larger beneficial effects.

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“…Meanwhile, more ROS inside the cells will lead to ageing [ 7 ]. Some theories have pointed out that antioxidants can increase the antioxidant ability of organisms to defend against oxidative stress, and in some ways they are also able to slow down ageing [ 8 , 9 , 10 , 11 ]. Therefore, it is urged to find appropriate antioxidants to reduce oxidation.…”

Section: Introductionmentioning

confidence: 99%

Polyphenols from Blumea laciniata Extended the Lifespan and Enhanced Resistance to Stress in Caenorhabditis elegans via the Insulin Signaling Pathway

et al. 2021

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Blumea laciniata is widely used as a folk medicine in Asia, but relevant literature on it is rarely reported. We confirmed that polyphenol extract (containing chlorogenic acid, rutin, and luteolin-4-O-glucoside) from B. laciniata (EBL) showed strong antioxidant ability in vitro. Hence, in this work, we applied Caenorhabditis elegans to further investigate the antioxidant and anti-ageing abilities of EBL in vivo. The results showed that EBL enhanced the survival of C. elegans under thermal stress by 12.62% and sharply reduced the reactive oxygen species level as well as the content of malonaldehyde. Moreover, EBL increased the activities of antioxidant enzymes such as catalase and superoxide dismutase. Additionally, EBL promoted DAF-16, a transcription factor, into the nucleus. Besides, EBL extended the lifespan of C. elegans by 17.39%, showing an anti-ageing effect. Different mutants indicated that the insulin/IGF-1 signaling pathway participated in the antioxidant and anti-ageing effect of EBL on C. elegans.

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Dissecting the Potential of Selenoproteins Extracted from Selenium-Enriched Rice on Physiological, Biochemical and Anti-Ageing Effects In Vivo

Cited by 35 publications

References 32 publications

Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice

Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice

Risk–Benefit Assessment of Consumption of Rice for Adult Men in China

Polyphenols from Blumea laciniata Extended the Lifespan and Enhanced Resistance to Stress in Caenorhabditis elegans via the Insulin Signaling Pathway

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