Dissecting Murine Muscle Stem Cell Aging through Regeneration Using Integrative Genomic Analysis

Shcherbina, Anna; Larouche, Jacqueline; Fraczek, Paula; Yang, Benjamin; Brown, Lemuel A.; Markworth, James F.; Chung, Carolina H; Khaliq, Mehwish; Silva, Kanishka de; Choi, Jeongmoon J.; Fallahi-Sichani, Mohammad; Chandrasekaran, Sriram; Jang, Young C.; Brooks, Susan V.; Aguilar, Carlos A.

doi:10.1016/j.celrep.2020.107964

Cited by 53 publications

(70 citation statements)

References 95 publications

(82 reference statements)

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“…Besides the transcription factors that determine SC fate, epigenetic changes in SCs have been shown to regulate myogenic differentiation (Liu et al, 2013;Wang et al, 2019;Shcherbina et al, 2020). Histones are proteins that provide structural support for packing DNA.…”

Section: Role Of Satellite Cells In Skeletal Musclementioning

confidence: 99%

Lactate Metabolism and Satellite Cell Fate

2020

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Lactate is one of the metabolic products of glycolysis. It is widely accepted as an important energy source for many cell types and more recently has been proposed to actively participate in cell-cell communication. Satellite cells (SCs), which are adult skeletal muscle stem cells, are the main players of the skeletal muscle regeneration process. Recent studies have proposed a metabolic switch to increase glycolysis in activated SCs. Moreover, lactate has been shown to affect SCs and myoblasts in vivo and in vitro. In this short review, we describe how metabolic variations relate with SC fate (quiescence, activation, proliferation, migration, differentiation, fusion, and self-renewal), as well as discuss possible relationships between lactate as a metabolite and as a signaling molecule affecting SC fate.

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Section: Role Of Satellite Cells In Skeletal Musclementioning

confidence: 99%

Lactate Metabolism and Satellite Cell Fate

2020

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“…Recent advances in microengineered and molecular tools have enabled the study of cell–cell interactions with unprecedented granularity, advancing our knowledge of fundamental cell biology and enabling the development of novel therapeutic strategies that address a diverse range of diseases such as cancer progression and aging. [ 177 ]…”

Section: Discussionmentioning

confidence: 99%

Engineered Tools to Study Intercellular Communication

et al. 2020

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All multicellular organisms rely on intercellular communication networks to coordinate physiological functions. As members of a dynamic social network, each cell receives, processes, and redistributes biological information to define and maintain tissue homeostasis. Uncovering the molecular programs underlying these processes is critical for prevention of disease and aging and development of therapeutics. The study of intercellular communication requires techniques that reduce the scale and complexity of in vivo biological networks while resolving the molecular heterogeneity in “omic” layers that contribute to cell state and function. Recent advances in microengineering and high‐throughput genomics offer unprecedented spatiotemporal control over cellular interactions and the ability to study intercellular communication in a high‐throughput and mechanistic manner. Herein, this review discusses how salient engineered approaches and sequencing techniques can be applied to understand collective cell behavior and tissue functions.

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“…Intriguingly, in both the young and aged MPCs, treatment with all-trans-retinoic acid promoted quiescence and reduced proliferation in vitro. However, while all-trans-retinoic acid increased Pax7 levels in young MPCs, no difference in Pax7 levels were observed in old MPCs (Shcherbina et al, 2020). Vitamin D has been shown to improve functional recovery at 48 h and 7 days post-mechanical load induced muscle injury in young human males (Owens et al, 2015).…”

Section: Nutrient Availability and Dietary Factors Impact Skeletal Muscle Regeneration And Recoverymentioning

confidence: 96%

“…Thus, supplementation may be required to support optimal tissue regeneration. In another study, using genome-scale metabolic modeling, Shcherbina et al (2020) predicted reduced retinoic acid signaling in aged MPCs. They identified a reduction in retinoic acid (Vitamin A) receptor mRNA levels in MPCs from aged mice compared to MPCs from young mice.…”

Section: Nutrient Availability and Dietary Factors Impact Skeletal Muscle Regeneration And Recoverymentioning

confidence: 99%

Importance of Nutrient Availability and Metabolism for Skeletal Muscle Regeneration

et al. 2021

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Skeletal muscle is fundamentally important for quality of life. Deterioration of skeletal muscle, such as that observed with advancing age, chronic disease, and dystrophies, is associated with metabolic and functional decline. Muscle stem/progenitor cells promote the maintenance of skeletal muscle composition (balance of muscle mass, fat, and fibrotic tissues) and are essential for the regenerative response to skeletal muscle damage. It is increasing recognized that nutrient and metabolic determinants of stem/progenitor cell function exist and are potential therapeutic targets to improve regenerative outcomes and muscle health. This review will focus on current understanding as well as key gaps in knowledge and challenges around identifying and understanding nutrient and metabolic determinants of skeletal muscle regeneration.

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Dissecting Murine Muscle Stem Cell Aging through Regeneration Using Integrative Genomic Analysis

Cited by 53 publications

References 95 publications

Lactate Metabolism and Satellite Cell Fate

Lactate Metabolism and Satellite Cell Fate

Engineered Tools to Study Intercellular Communication

Importance of Nutrient Availability and Metabolism for Skeletal Muscle Regeneration

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