Disruptive Effect of Organotin on Thyroid Gland Function Might Contribute to Hypothyroidism

Oliveira, Mauro Dal Secco de; Rodrigues, Bruna Moretto; Olímpio, Regiane Marques Castro; Graceli, Jones Bernardes; Gonçalves, Bianca Mariani; Costa, Sarah Maria Barneze; Silva, Tabata Marinda da; Síbio, Maria Teresa De; Moretto, Fernanda Cristina Fontes; Mathias, Lucas Solla; Cardoso, Dariane Beatriz Marino; Tilli, Helena Paim; Freitas-Lima, Leandro Ceotto; Nogueira, Célia Regina

doi:10.1155/2019/7396716

Cited by 6 publications

(2 citation statements)

References 49 publications

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“…The oral administration of synthetic pyrethroid insecticide lambda-cyhalothrin to rats causes decreased T3 and T4 serum hormone concentration while increased TSH along with thyroid DNA damage suggesting primary hypothyroidism [11]. For many other chemical compounds like a biocide compound tributyltin chronic exposure causes declined T3 and T4 and elevated TSH concentrations pointing toward hypothyroidism along with many other thyroid disorders [12].…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Ashwagandha and Quercetin over Cypermethrin Induced Hypothyroidism: A Hematological Study in Mice

Namdev¹,

Rai²,

Mahobiya³

2023

azb

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Cypermethrin is a synthetic pyrethroid insecticide used worldwide for domestic as well as agriculture purposes. The current research is designed to investigate the protective role of ashwagandha and quercetin on cypermethrin-induced hematological alteration via declined thyroid function. Swiss albino male mice weighing around 25-30 g were divided into four groups of six animals each at random. Group I served as a control with normal food and water; Group II cypermethrin treated 15 mg/kg body weight; Group III ashwagandha co-treated 200 mg/kg body weight, and Group IV quercetin co-treated 150 mg/kg body weight. Doses were applied orally for 28 days. Blood was drawn, and hematological parameters and a serum thyroid hormone calculation were performed on it. Increased body weight and decreased thyroid weight were observed in the cypermethrin exposure group. The decreased T3 and T4 and increased TSH hormone levels were observed in the cypermethrin-treated group as compared to the control signified hypothyroidism. A significant decrease in erythrocyte count, hemoglobin percentage, and platelet counts was observed in the cypermethrin exposure group. Total leukocyte counts, neutrophil%, and lymphocyte% were increased significantly in the cypermethrin exposure group as compared to the control. A significantly decreased platelet count was observed in the cypermethrin exposure group. The antioxidant co-administered animals showed significant prevention as compared to cypermethrin-exposed animals.

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Section: Introductionmentioning

confidence: 99%

Protective Role of Ashwagandha and Quercetin over Cypermethrin Induced Hypothyroidism: A Hematological Study in Mice

Namdev¹,

Rai²,

Mahobiya³

2023

azb

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“…The thyroid function test is one of the most common laboratory tests usually done to investigate mood disorders. There is evidence that hypothyroidism can cause signs and symptoms of depression in humans (21). Some studies have shown increased T4 levels during the depression, while others have not shown this correlation (22).…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Effects of Noise Pollution on the Levels of Blood Cortisol, Testosterone, and Thyroid in Male Wistar Rats

et al. 2021

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Background: Noise pollution is a global problem causing changes in the secretion of various hormones and consequently affecting social well-being and quality of life in cities. Objectives: This study aimed to investigate the effect of noise pollution on the levels of testosterone, thyroid, and cortisol hormones in male rats. Methods: In this experimental study, a total of 70 male Wistar rats (200 - 250 g) were randomly assigned into one control and six experimental groups, with 10 rats in each group. Experimental groups were exposed to noise with different intensity (dB) and time (min) as follows: (I) 60 dB, 30 min; (II) 60 dB, 60 min; (III) 85 dB, 30 min; (IV) 85 dB, 60 min; (V) 110 dB, 30 min; (VI) 110 dB, 60 min; (VII) controls. Animals in the experimental groups were exposed to noise in an acoustic chamber designed for this purpose for 50 days. The Noise.exe software was used to generate noise, and the sound level meter (model TES 1358) was used to determine the accuracy of the intensity and frequency of sound. To determine plasma levels of the hormones, appropriate research and commercial kits were used, which were based on the ELISA method. To determine the concentration of hormones other than TSH, human assay kits were used. All statistical tests were performed in SPSS software version 21. Results: Serum levels of cortisol in the 110-dB (30 and 60 min), 65-dB (60 min), and 85-dB (60 min) groups were significantly higher than the control group (P ≤ 0.05). Also, cortisol levels in the 65-dB and 85-dB (30 minutes) groups were higher than the control group; however, the increase was not significant (P > 0.05). The levels of T4, T3, and TSH in the 60-dB and 85-dB groups were significantly lower than in the control group (P ≤ 0.05). The serum levels of T4, T3, and TSH hormones in the 110-dB group were insignificantly lower than the control group (P > 0.05). The serum level of testosterone in the 110-dB group was significantly lower than the control group (P ≤ 0.05). The mean serum levels of testosterone in the 65-dB and 85-dB groups were insignificantly lower than the control group (P > 0.05). Conclusions: Based on this study, exposure to noise pollution increased cortisol secretion and decreased T4, T3, TSH, and testosterone levels in rats. As this hormonal imbalance may create direct and indirect effects, studies and strategies are recommended to control the imbalance of hormones in the polluted environments.

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Herbs and Spices as Natural Medicine for Treatment of Metabolic Disorders

Itrat

2020

Emerging Contaminants and Associated Treatment Technologies

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Disruptive Effect of Organotin on Thyroid Gland Function Might Contribute to Hypothyroidism

Cited by 6 publications

References 49 publications

Protective Role of Ashwagandha and Quercetin over Cypermethrin Induced Hypothyroidism: A Hematological Study in Mice

Protective Role of Ashwagandha and Quercetin over Cypermethrin Induced Hypothyroidism: A Hematological Study in Mice

Evaluating the Effects of Noise Pollution on the Levels of Blood Cortisol, Testosterone, and Thyroid in Male Wistar Rats

Herbs and Spices as Natural Medicine for Treatment of Metabolic Disorders

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