Disruption of vascular endothelial homeostasis in systemic juvenile idiopathic arthritis-associated macrophage activation syndrome: The dynamic roles of angiopoietin-1 and -2

Tasaki, Yuko; Shimizu, Masaki; Inoue, Natsumi; Mizuta, Mao; Nakagishi, Yasuo; Wada, Taizo; Yachie, Akihiro

doi:10.1016/j.cyto.2016.02.008

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…Angiopoietins (Ang)-1 and − 2 are key regulators of endothelial cell function. The serum Ang-2/1 ratio has been signi cantly elevated during the MAS phase in sJIA [8] . Disruption of vascular endothelial homeostasis by Ang-1 and Ang-2 abnormalities might play a role in the uncommon features of vasculitis and thrombosis in sJIA.…”

Section: Discussionmentioning

confidence: 95%

Pulmonary involvements in systemic juvenile arthritis

He¹,

Ling²,

Yang³

2020

Preprint

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Background Systemic juvenile idiopathic arthritis (sJIA) is a chronic inflammatory disease of childhood. Pulmonary involvements in sJIA have been recently described. Herein, we assess unusual clinical and radiological features of patients with sJIA, and possible risk factors for pulmonary involvements in sJIA. Methods A total of thirty-nine patients with sJIA were retrospectively enrolled. Data extracted included demographics, medical history, clinical manifestations, laboratory results, serum cytokine levels, radiological findings, management, and prognosis. Results Macrophage activation syndrome (MAS) had been observed at the initial diagnosis or during disease flares in eleven patients (11/39, 28%). Cerebral venous sinus thrombosis was observed in one patient with paroxysmal headache during the MAS phase. Twenty-three patients demonstrated abnormal radiological features on chest Computed Tomography (CT). Only eleven patients had subtle respiratory symptoms with normal oxygen saturation. Eight patients had lung disease (LD) before biologic exposure. sJIA-LD occurred in another six patients after the introduction of tocilizumab. All these patients continued to receive tocilizumab therapy, and sJIA-LD was improved in twelve patients with complete resolution of pulmonary presentations, and partially relieved in two patients. Only one of the two patients with possible anaphylaxis to tocilizumab presented with LD. Severe sJIA-LD was found in two patients with trisomy 21 and Kabuki syndrome, respectively. Conclusions Pulmonary involvements are increasingly observed in children with sJIA. Possible high risks for sJIA-LD include the occurrence of MAS, some inherited diseases, and evidence of drug hypersensitivity. It is still a question of whether IL-1/IL-6 inhibitor exposure increases the risk of sJIA-LD. Vasculitis and thrombosis should be considered in sJIA during the MAS phase, particularly in patients with pulmonary involvements. Trial registration: Not applicable; this was a retrospective study.

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Section: Discussionmentioning

confidence: 95%

Pulmonary involvements in systemic juvenile arthritis

He¹,

Ling²,

Yang³

2020

Preprint

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“…We have included the studies showing the role of angiopoietins in vascular calcification, diabetic retinopathy, diabetic nephropathy, chronic kidney disease, inflammatory bowel disease, pulmonary hypertension, and psoriasis. Additionally, angiopoietins have important causal or diagnostic roles in arthritis [ 274 , 275 , 276 , 277 , 278 , 279 , 280 , 281 ], psoriasis [ 282 ], and infertility [ 283 , 284 , 285 ]. For a detailed role of angiopoietins in ischemia, readers are directed to several excellent reviews [ 286 , 287 , 288 ].…”

Section: Role Of Angiopoietins Beyond Angiogenesismentioning

confidence: 99%

Friends Turned Foes: Angiogenic Growth Factors beyond Angiogenesis

et al. 2017

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Angiogenesis, the formation of new blood vessels from pre-existing ones is a biological process that ensures an adequate blood flow is maintained to provide the cells with a sufficient supply of nutrients and oxygen within the body. Numerous soluble growth factors and inhibitors, cytokines, proteases as well as extracellular matrix proteins and adhesion molecules stringently regulate the multi-factorial process of angiogenesis. The properties and interactions of key angiogenic molecules such as vascular endothelial growth factors (VEGFs), fibroblast growth factors (FGFs) and angiopoietins have been investigated in great detail with respect to their molecular impact on angiogenesis. Since the discovery of angiogenic growth factors, much research has been focused on their biological actions and their potential use as therapeutic targets for angiogenic or anti-angiogenic strategies in a context-dependent manner depending on the pathologies. It is generally accepted that these factors play an indispensable role in angiogenesis. However, it is becoming increasingly evident that this is not their only role and it is likely that the angiogenic factors have important functions in a wider range of biological and pathological processes. The additional roles played by these molecules in numerous pathologies and biological processes beyond angiogenesis are discussed in this review.

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Clinical Features of Cytokine Storm Syndrome

Shimizu

2019

Cytokine Storm Syndrome

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Disruption of vascular endothelial homeostasis in systemic juvenile idiopathic arthritis-associated macrophage activation syndrome: The dynamic roles of angiopoietin-1 and -2

Cited by 5 publications

References 21 publications

Pulmonary involvements in systemic juvenile arthritis

Pulmonary involvements in systemic juvenile arthritis

Friends Turned Foes: Angiogenic Growth Factors beyond Angiogenesis

Clinical Features of Cytokine Storm Syndrome

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