Disruption of erythrocyte antioxidant defense system, hematological parameters, induction of pro-inflammatory cytokines and DNA damage in liver of co-exposed rats to aluminium and acrylamide

Ghorbel, Imen; Maktouf, Sameh; Kallel, Choumous; Châabouni, Semia Ellouz; Boudawara, Tahia; Zeghal, Najiba

doi:10.1016/j.cbi.2015.04.020

Cited by 50 publications

(37 citation statements)

References 53 publications

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“…Because GSH is involved in recycling vitamin C by mediating the reduction of dehydroascorbate (41), the GSH deficiency would be expected to reduce the vitamin C levels in treated rats. As has been previously reported by us, exposure of rats to acrylamide at a dose of 20 mg/Kg BW induces lipid peroxidation as well as a reduction of the antioxidant system in erythrocytes (42). EVOO administration improved significantly the levels of antioxidant status in erythrocytes to near normal values through SH groups protection and by scavenging free radicals.…”

Section: Analytical Parameters Mean Valuessupporting

confidence: 74%

Extra Virgin olive oil mitigates hematotoxicity induced by acrylamide and oxidative damage in adult rats

et al. 2017

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Section: Analytical Parameters Mean Valuessupporting

confidence: 74%

Extra Virgin olive oil mitigates hematotoxicity induced by acrylamide and oxidative damage in adult rats

et al. 2017

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“…In case of unbalance between free radicals and antioxidants, an oxidative stress could be induced causing chronic permanent damage (Chipman et al 2006). Nowadays, erythrocytes are used to study xenobiotics effects as they are sensitive to the peroxidation process (Ghorbel et al 2015). Their membranes are also susceptible to covalent damage, including cross-linking and aggregation by free radical-induced peroxidation products like superoxides resulting from Hb autooxidation.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of pomegranate peel against hematotoxicity, chromosomal aberrations, and genotoxicity induced by barium chloride in adult rats

Elwej

Salah

Kallel

et al. 2016

Pharmaceutical Biology

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Context Pomegranate peel (PP) has health benefits including antibacterial, antioxidant, antiinflammatory, and antimutagenic properties. Objective This study investigated the biochemical composition and protective effects of PP against hematotoxicity and genotoxicity induced by barium chloride (BaCl 2 ) in adult rats. Materials and methods Adult Wistar rats were divided into four groups of six each: control, barium (67 ppm via drinking water), PP (5% via diet), and their combination during 21 d. Oxidative stress was determined by MDA, AOPP, and antioxidant status: CAT, GPx, GSH, Vit C. Osmotic fragility (OF), chromosomal aberrations (CAs), and micronucleus (MN) assays were also studied. Results PP showed a rich composition of antioxidant compounds. DPPH test found IC 50 value¼ 5.3 mg/mL and a high polysaccharides content (315 ± 5 mg/g of extract). In vivo study showed a decrease in red blood cells (70%) and platelet counts (46%), hemoglobin content (8%), hematocrit percent (7%), and an 80% increase of white blood cells in Ba-treated rats. A reduction in antioxidant status: catalase, glutathione peroxidase activities, glutathione, and vitamin C levels by 31, 21, 28, and 29%, respectively, and an increase in MDA (46%) and AOPP levels (72%) were also observed compared with controls. BaCl 2 -treatment showed a significant increase in the frequencies of total chromosomal aberrations with abnormal metaphases and micronucleus in bone-marrow cells. Oxidative stress induced by BaCl 2 might be the major cause for chromosomal abnormalities leading to DNA damage. Discussion and conclusion A decrease in hematotoxic and genotoxic effects induced by PP is due to its powerful antioxidant capacity. ARTICLE HISTORY

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“…The diminished platelets count may apparently be due to the decreased production of thrombopoietin hormone by damaged liver cells. The decrease in lymphocytes and enhanced neutrophil counts might suggest the decrease in efficiency of an immune system to cope up with the triggered inflammatory cascade [40] . Similar observations were also noticed by Farooq et al [41] and Gangar et al [42] , who also observed the alterations in various hematological parameters in patients suffering from gastric and forestomach carcinoma respectively.…”

Section: Discussionmentioning

confidence: 99%

Lycopene treatment stalls the onset of experimentally induced hepatocellular carcinoma: a radioisotopic, physiological and biochemical analysis

Bhatia¹,

Singh²,

Koul³

2018

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Tc-mebrofenin excretion. NDEA treatment also caused alterations in the hematological parameters such as hemoglobin, red blood cells, platelets and total leucocyte counts. A significant increase in plasma lipid peroxidation and decrease in reduced glutathione levels with alterations in various enzymatic antioxidants were observed upon NDEA treatment. LycT pre-treatment aided in boosting the antioxidant defense system and ameliorated the inflammatory and hematological alterations. Conclusion:As evident by improved functional, hematological and biochemical markers, it may be inferred that LycT has the potential to delay HCC initiation.

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Disruption of erythrocyte antioxidant defense system, hematological parameters, induction of pro-inflammatory cytokines and DNA damage in liver of co-exposed rats to aluminium and acrylamide

Cited by 50 publications

References 53 publications

Extra Virgin olive oil mitigates hematotoxicity induced by acrylamide and oxidative damage in adult rats

Extra Virgin olive oil mitigates hematotoxicity induced by acrylamide and oxidative damage in adult rats

Protective effects of pomegranate peel against hematotoxicity, chromosomal aberrations, and genotoxicity induced by barium chloride in adult rats

Lycopene treatment stalls the onset of experimentally induced hepatocellular carcinoma: a radioisotopic, physiological and biochemical analysis

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