Disruption of appetite but not hunger or satiety following small lesions in the amygdala of rats.

Schoenfeld, Thomas A.; Hamilton, Leonard W.

doi:10.1037/h0077801

Cited by 44 publications

(24 citation statements)

References 44 publications

(55 reference statements)

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“…This ''within group'' comparison controls for many sources of variability, which is an advantage when small sample sizes are studied (Zolman, 1993;Rasia-Filho and Lucion, 1996;de Castilhos et al, 2006). However, these novel data did not provide strong evidence that the MePD would be contributing to direct goal-oriented feeding behavior or hunger and polyphagia (Schoenfeld and Hamilton, 1981;Rollins et al, 2006). In addition, there are few data to support an involvement of the MeA subnuclei with learning of appetitive motivated tasks such as drinking of taste solutions or eating more palatable food (reviewed in Knapska et al, 2007).…”

Section: Discussionmentioning

confidence: 98%

“…The feeding behavior of homeostatically challenged, food-deprived rats having a self-selection macronutrient diet is the resultant of serial and parallel neural connections needed for processing multiple sensorial information, metabolic/hormonal internal demands, and organization of behavioral displays (Schoenfeld and Hamilton, 1981;Newman, 1999;Berthoud, 2002). However, the influence of the MePD upon different hypothalamic nuclei that control neuroendocrine secretion or behavior display is far from simple.…”

Section: Discussionmentioning

confidence: 99%

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Glutamate Microinjected in the Posterodorsal Medial Amygdala Induces Subtle Increase in the Consumption of a Three‐Choice Macronutrient Self‐Selection Diet in Male Rats

Rosa¹,

Goularte²,

Trindade³

et al. 2011

The Anatomical Record

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Previous studies have involved the ''posterodorsal'' amygdaloid area with the control of food intake and the development of obesity in rats. Within this wide region, the posterodorsal medial amygdala (MePD) has connections with specific hypothalamic nuclei that increase feeding behavior and modulate energy balance. Glutamate is the major brain excitatory neurotransmitter, remarkably enhances centrally mediated food consumption, and is abundantly found in the MePD. Here, it was studied the effects of saline (0.3 lL) and glutamate (45 nM or 45 mM/0.3 lL) directly microinjected in the MePD of adult male rats on the consumption of a three-choice (high-carbohydrate, high-protein, or high-lipid) macronutrient selective diet. The rat adaptation to the experimental procedures and its body weight gain were continuously evaluated. Control data for all groups and results following microinjections were obtained after a fasting protocol. Feeding behavior was evaluated during the subsequent 2-hr period of free access to the selective diets. Both doses of glutamate microinjected in the MePD did not lead to a higher percentage of animals consuming any of the different diets (P > 0.05), although glutamate 45 mM induced a higher consumption of the high-carbohydrate diet when compared with presurgery control values (P < 0.01). Interestingly, present data indicate that glutamate in the male MePD induces only a subtle modification in the feeding behavior and suggest that large electrolytic lesions of the ''posterodorsal'' amygdaloid region might have affected other regions to alter drastically meal size consumption in rats. Anat Rec, 294:1226Rec, 294: -1232Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Glutamate Microinjected in the Posterodorsal Medial Amygdala Induces Subtle Increase in the Consumption of a Three‐Choice Macronutrient Self‐Selection Diet in Male Rats

Rosa¹,

Goularte²,

Trindade³

et al. 2011

The Anatomical Record

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“…Besides hypothalamic regions, GLP-1 has also been shown to be present in the amygdala (15), which does not only provide afferent neuronal input to the hypothalamus via the amygdalofugal pathway (21) but also may play a role in the regulation of ingestive behavior (3,9,42). At the extrahypothalamic region of the amygdala, however, GLP-1 was not able to alter feeding behavior.…”

Section: Glp-1 and A High Density Of Glp-1 Receptors Havementioning

confidence: 97%

“…Within the hypothalamus, GLP-1-containing nerve fibers and terminals have been shown to be located in the paraventricular nucleus of the hypothalamus (PVN), the ventromedial hypothalamus (VMH), dorsomedial hypothalamus (DMH), and lateral hypothalamus (LH), well known as integrative areas for feeding regulation (12,15,23). In addition, GLP-1 is also present in the amygdala (15), a brain region providing neuronal input to the hypothalamus and participating in the regulation of ingestive behavior (3,9,21,42). In all these areas, the presence of GLP-1 receptors has recently been demonstrated (11).…”

mentioning

confidence: 99%

Glucagon-like peptide 1-(7–36) amide acts at lateral and medial hypothalamic sites to suppress feeding in rats

Schick

Zimmermann

Walde

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

128

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Glucagon-like peptide 1-(7-36) amide (GLP-1) potently inhibits rat feeding behavior after central administration. Because third ventricular injection of GLP-1 appeared to be less effective than lateral ventricular injection, we have reexamined this issue. In addition, we attempted to identify brain regions other than the paraventricular nucleus of the hypothalamus that are sensitive toward GLP-1-induced feeding suppression. Finally, we examined the local role of endogenous GLP-1 by specific GLP-1 receptor blockade. After lateral ventricular injection, GLP-1 significantly inhibited food intake of 24-h-fasted rats in a dose-dependent fashion with a minimal effective dose of 1 microg. After third ventricular injection, GLP-1 (1 microg) was similarly effective in suppressing food intake, which extends previous findings. Intracerebral microinjections of GLP-1 significantly suppressed food intake in the lateral (LH), dorsomedial (DMH), and ventromedial hypothalamus (VMH), but not in the medial nucleus of the amygdala. The minimal effective dose of GLP-1 was 0.3 microg at LH sites and 1 microg at DMH or VMH sites. LH microinjections of exendin-(9-39) amide, a GLP-1 receptor antagonist, at 1 or 2.5 microg did not alter feeding behavior in 24-h-fasted rats. In satiated animals, however, a single LH injection of 1 microg exendin-(9-39) amide significantly augmented food intake, but only during the first 20 min (0.6 vs. 0.1 g). With three repeated injections of 2.5 microg exendin-(9-39) amide every 20 min, 1-h food intake was significantly increased by 300%. These data strongly support and extend the concept of GLP-1 as a physiological regulator of food intake in the hypothalamus.

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“…Norgren [1976], who recorded antidromic activation from the vicinity of the central nucleus to gustatory units in the pons, hypothesized that this amygdaloid region acts as a relay for taste information. This rich sensory innervation provides a neuroanatomical correlate to the notion that the amygdala primarily mediates the appetite experience, but is without influence on hunger and body weight regulation [Schoenfeld and Hamilton, 1981]. The medial posterodorsal and central amygdaloid nuclei are further innervated from the arcuate nucleus [Ottersen, 1980;Broberger et al, 1998a], and also here are CART-ir neurons closely apposed by NPY-ir terminals [Broberger, 1999].…”

Section: Mesolimbic Structures and The Amygdalamentioning

confidence: 89%

Cocaine- and amphetamine-regulated transcript (CART) and food intake: Behavior in search of anatomy

Broberger

2000

Drug Dev. Res.

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Disruption of appetite but not hunger or satiety following small lesions in the amygdala of rats.

Cited by 44 publications

References 44 publications

Glutamate Microinjected in the Posterodorsal Medial Amygdala Induces Subtle Increase in the Consumption of a Three‐Choice Macronutrient Self‐Selection Diet in Male Rats

Glutamate Microinjected in the Posterodorsal Medial Amygdala Induces Subtle Increase in the Consumption of a Three‐Choice Macronutrient Self‐Selection Diet in Male Rats

Glucagon-like peptide 1-(7–36) amide acts at lateral and medial hypothalamic sites to suppress feeding in rats

Cocaine- and amphetamine-regulated transcript (CART) and food intake: Behavior in search of anatomy

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