Disrupted topological properties of the structural brain network in patients with cerebellar infarction on different sides are associated with cognitive impairment

Wang, Duohao; Yao, Qun; Lin, Xingjian; Hu, Jun; Shi, Jingping

doi:10.3389/fneur.2022.982630

“…The study revealed that patients with cerebellar damage exhibited impairments in the allocation of spatio-temporal attention (Craig et al, 2021). In a similar vein, Wang et al (2021) enrolled 36 patients with posterior cerebellar infarction and 30 healthy volunteers for cognitive neurofunctional assessment and MRI scans to extract parameters related to the structural topological features of brain networks. The findings of this study indicated reduced global and local efficiency of brain networks, along with increased clustering coefficients and shortest path lengths within the patient group.…”

Section: Cerebellum and Attentional Functionmentioning

confidence: 97%

“…The findings of this study indicated reduced global and local efficiency of brain networks, along with increased clustering coefficients and shortest path lengths within the patient group. The authors attributed the observed attentional dysfunction in the cerebellar infarction group to diminished connectivity efficiency within the cerebellar and default networks, as well as the frontotemporoparietal network (Wang et al, 2021). Furthermore, Mannarelli investigated changes in the amplitude of the P3b wave, which is indicative of alterations in attentional function, at various time points in a patient with left posterior lobe cerebellar infarction.…”

Section: Cerebellum and Attentional Functionmentioning

confidence: 99%

The cerebellum and cognitive neural networks

Zhang

¹

,

Duan

²

,

Yu-xiang

³

et al. 2023

Front. Hum. Neurosci.

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Cognitive function represents a complex neurophysiological capacity of the human brain, encompassing a higher level of neural processing and integration. It is widely acknowledged that the cerebrum plays a commanding role in the regulation of cognitive functions. However, the specific role of the cerebellum in cognitive processes has become a subject of considerable scholarly intrigue. In 1998, Schmahmann first proposed the concept of “cognitive affective syndrome (CCAS),” linking cerebellar damage to cognitive and emotional impairments. Since then, a substantial body of literature has emerged, exploring the role of the cerebellum in cognitive neurological function. The cerebellum’s adjacency to the cerebral cortex, brainstem, and spinal cord suggests that the cerebral-cerebellar network loops play a crucial role in the cerebellum’s participation in cognitive neurological functions. In this review, we comprehensively examine the recent literature on the involvement of the cerebellum in cognitive functions from three perspectives: the cytological basis of the cerebellum and its anatomical functions, the cerebellum and cognitive functions, and Crossed cerebellar diaschisis. Our aim is to shed light on the role and mechanisms of the cerebellum in cognitive neurobrain networks.

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“…The known connectivity of the cerebellum with contralateral cerebral regions necessarily raises the question of whether damage to the left or right side of the cerebellum might result in deficits in attention/spatial processing or language (respectively). Although there is a good deal of evidence that language functions are more lateralized to the right cerebellum (for reviews see Marien & Borgatti, 2018;Stoodley & Stein, 2011), the role of the left cerebellum in attention and spatial functions is less established (e.g., Allen, Buxton, Wong, & Courchesne, 1997;Baier, Dieterich, Stoeter, Birklein, & Muller, 2010;Oliver Baumann & Mattingley, 2014;Brissenden, Levin, Osher, Halko, & Somers, 2016;Brissenden & Somers, 2019;Craig, Morrill, Anderson, Danckert, & Striemer, 2021;Gottwald, Mihajlovic, Wilde, & Mehdorn, 2003;Gottwald, Wilde, Mihajlovic, & Mehdorn, 2004;Molinari, Petrosini, Misciagna, & Leggio, 2004;Schweizer, Alexander, Cusimano, & Stuss, 2007;Starowicz-Filip et al, 2021;Striemer, Cantelmi, Cusimano, Danckert, & Schweizer, 2015;Striemer, Chouinard, Goodale, & de Ribaupierre, 2015;Wang, Yao, Lin, Hu, & Shi, 2022).…”

Section: Introductionmentioning

confidence: 99%

Left Cerebellar Lesions may be Associated with an Increase in Spatial Neglect-like Symptoms

Verbitsky

¹

,

Anderson

²

,

Danckert

³

et al. 2023

Cerebellum

2

0

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Each cerebellar hemisphere projects to the contralateral cerebral hemisphere. Previous research suggests a lateralization of cognitive functions in the cerebellum that mirrors the cerebral cortex, with attention/visuospatial functions represented in the left cerebellar hemisphere, and language functions in the right cerebellar hemisphere. Although there is good evidence supporting the role of the right cerebellum with language functions, the evidence supporting the notion that attention and visuospatial functions are left lateralized is less clear. Given that spatial neglect is one of the most common disorders arising from right cortical damage, we reasoned that damage to the left cerebellum would result in increased spatial neglect-like symptoms, without necessarily leading to an official diagnosis of spatial neglect. To examine this disconnection hypothesis, we analyzed neglect screening data (line bisection, cancellation, figure copying) from 20 patients with isolated unilateral cerebellar stroke. Results indicated that left cerebellar patients (n=9) missed significantly more targets on the left side of cancellation tasks compared to a normative sample. No significant effects were observed for right cerebellar patients (n=11). A lesion overlap analysis indicated that Crus II (78% overlap), and lobules VII and IX (66% overlap) were the regions most commonly damaged in left cerebellar patients. Our results are consistent with the notion that the left cerebellum may be important for attention and visuospatial functions. Given the poor prognosis typically associated with neglect, we suggest that screening for neglect symptoms, and visuospatial deficits more generally, may be important for tailoring rehabilitative efforts to help maximize recovery in cerebellar patients.

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Left cerebellar lesions may be associated with an increase in spatial neglect-like symptoms.

Verbitsky¹,

Anderson²,

Danckert³

et al. 2023

Preprint

0

View full text Add to dashboard Cite

Each cerebellar hemisphere projects to the contralateral cerebral hemisphere. Previous research suggests a lateralization of cognitive functions in the cerebellum that mirrors the cerebral cortex, with attention/visuospatial functions represented in the left cerebellar hemisphere, and language functions in the right cerebellar hemisphere. Although there is good evidence supporting the role of the right cerebellum with language functions, the evidence supporting the notion that attention and visuospatial functions are left lateralized is less clear. Given that spatial neglect is one of the most common disorders arising from right cortical damage, we reasoned that damage to the left cerebellum would result in increased spatial neglect-like symptoms, without necessarily leading to an official diagnosis of spatial neglect. To examine this disconnection hypothesis, we analyzed neglect screening data (line bisection, cancellation, figure copying) from 20 patients with isolated unilateral cerebellar stroke. Results indicated that left cerebellar patients (n=9) missed significantly more targets on the left side of cancellation tasks compared to a normative sample. No significant effects were observed for right cerebellar patients (n=11). A lesion overlap analysis indicated that Crus II (78% overlap), and lobules VII and IX (66% overlap) were the regions most commonly damaged in left cerebellar patients. Our results are consistent with the notion that the left cerebellum may be important for attention and visuospatial functions. Given the poor prognosis typically associated with neglect, we suggest that screening for neglect symptoms, and visuospatial deficits more generally, may be important for tailoring rehabilitative efforts to help maximize recovery in cerebellar patients.

show abstract

Disrupted topological properties of the structural brain network in patients with cerebellar infarction on different sides are associated with cognitive impairment

Cited by 3 publications

References 50 publications

The cerebellum and cognitive neural networks

The cerebellum and cognitive neural networks

Left Cerebellar Lesions may be Associated with an Increase in Spatial Neglect-like Symptoms

Left cerebellar lesions may be associated with an increase in spatial neglect-like symptoms.

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