Disrupted social connectedness among Dominican women with chronic filarial lymphedema

Person, Bobbie; Bartholomew, L. Kay; Addiss, David G.; Borne, Bart van den

doi:10.1016/j.pec.2007.06.015

Cited by 32 publications

(34 citation statements)

References 39 publications

(43 reference statements)

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“…In this study, an association was found between stigma and factors including monthly income, marital status, and disease stage after controlling for confounders. Similarly, disease stage was found to be associated with stigma among LF patients in other studies [29,35]. This may be because increased podoconiosis disease stage is more visible than lower stages.…”

Section: Discussionsupporting

confidence: 59%

“…Age and social role appeared to influence social connectedness among LF patients in a study by Person et al . [29]. In the same study, stigma appeared to be correlated with increasing disease stage [29].…”

Section: Introductionmentioning

confidence: 90%

“…[29]. In the same study, stigma appeared to be correlated with increasing disease stage [29]. Higher grades of lymphoedema and hydrocele were also associated with increased stigma in a study by Kumari et al .…”

Section: Introductionmentioning

confidence: 90%

“…Health-related stigma has been described for other major NTDs including lymphatic filariasis (LF), schistosomiasis, onchocerciasis, leishmaniasis, Buruli ulcer and leprosy [20-29]. Studies have described NTD-related stigma experiences in a broad range of domains.…”

Section: Introductionmentioning

confidence: 99%

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Stigma towards a Neglected Tropical Disease: Felt and enacted Stigma Scores among Podoconiosis Patients in Northern Ethiopia

et al. 2013

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BackgroundPodoconiosis, or non-filarial elephantiasis, is a neglected tropical disease (NTD) characterised by swelling of the lower legs. When left untreated, this disfiguring condition has a significant social impact. This study aimed to describe the stigma experience among podoconiosis patients in Dembecha, Northern Ethiopia and assess potential associations between stigma and sociodemographic determinants.MethodsThe study was conducted in May 2012 in Northern Ethiopia. A questionnaire-based cross-sectional study design was used and stigma was assessed using a validated podoconiosis stigma scale including 'felt’ and 'enacted’ stigma domains. Enacted stigma includes the experience of discrimination such as abuse, loss of employment or prejudicial attitudes, while felt stigma is the perceived fear of enacted stigma. A multivariable linear regression model was used to explore determinants that may be associated with stigma.ResultsA total of 346 clinically confirmed podoconiosis patients participated in the study. The total mean score of all stigma scale items was 30.7 (Range = 0 to 96). There was a higher mean score of scale items in domains of felt stigma (21.7; Range = 0 to 45) as compared to enacted stigma (9.0; Range = 0 to 51). The total mean score of all stigma scale items appeared to increase with disease stage. A final adjusted linear regression model found an association between stigma and factors including monthly income, duration lived in the current residence, and disease stage, after controlling for confounders.ConclusionPodoconiosis is a stigmatized disease with a clear social impact. This paper documented the burden of podoconiosis-related stigma and identified associated factors. Programs aimed at preventing and treating podoconiosis should incorporate interventions to mitigate both felt and enacted stigma. Interventions targeting patients should prioritize those with advanced disease.

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Section: Discussionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Stigma towards a Neglected Tropical Disease: Felt and enacted Stigma Scores among Podoconiosis Patients in Northern Ethiopia

et al. 2013

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“…4 Affected individuals often suffer impairment of daily activities and social isolation in addition to the pain and discomfort of severe disease. 5 The Dominican Ministry of Health created the Program to Eliminate Lymphatic Filariasis (PELF) in 1998 to coordinate national LF elimination. Patterned after the global strategy, PELF targets elimination of LF through 1) annual mass drug administration (MDA) of albendazole (donated by GlaxoSmithKline) and diethylcarbamazine (DEC) to interrupt LF transmission by 2020; and 2) morbidity control to alleviate disability for those already infected.…”

mentioning

confidence: 99%

Post-Mass Drug Administration Transmission Assessment Survey for Elimination of Lymphatic Filariasis in La Ciénaga, Dominican Republic

Noland

Blount

Gonzalez

2015

The American Society of Tropical Medicine and Hygiene

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Abstract. The Dominican Republic is one of four remaining countries in the Americas with lymphatic filariasis (LF). Annual mass drug administration (MDA) with albendazole and diethylcarbamazine was conducted in La Ciénaga, an impoverished urban barrio in Santo Domingo, from 2004 to 2006. Eight years after the last MDA, a transmission assessment survey (TAS) was conducted in November-December 2014 to determine if LF transmission remains absent. Of 815 first and second grade primary school students (mean age: 6.51 years; range 5-9) tested by immunochromatographic test (ICT), zero (0.0%) were positive. This is below the TAS critical cutoff of nine, indicating that the area "passed" TAS and that transmission remains interrupted in La Ciénaga. Importantly, this also provides evidence that three rounds of effective (> 65% coverage) MDA, likely aided by environmental improvements and periodic school-based albendazole monotherapy MDA, achieved interruption of LF transmission from a relatively low-transmission setting.

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Nephrin expression and three‐dimensional morphogenesis of the Xenopus pronephric glomus

Gerth¹,

Zhou²,

Vize³

2005

Developmental Dynamics

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Nephrin (NHPS1) encodes a transmembrane protein of approximately 1,200 amino acids that plays a critical role in podocyte slit-diaphragm formation and the development of functional mammalian glomerular filtration barriers. In humans and mice with congenital defects in the nephrin gene, the glomerular filtration barrier is defective and protein leakage into the kidney filtrate causes a life-threatening proteinuria. This protein also plays an essential role in the formation of the stellate cells of the Drosophila Malpighian tubules. In this report, the sequence and expression of a Xenopus ortholog of nephrin is described using both conventional and novel three-dimensional (3D) visualization methodologies. Xenopus nephrin encodes a protein of 1,238 amino acids and is expressed at high levels in the forming pronephric kidney glomus, the equivalent of the mammalian glomerulus. Expression commences at stage 25 and is specific to the pronephric glomus up until at least tadpole feeding stages. Two-color fluorescent wholemount in situ analysis of nephrin expression allowed the 3D shape of the glomus to be imaged and contrasted to the pronephric tubules throughout its morphogenesis. Confocal data processing pipelines were established to generate both volumetric and surface models of the developing pronephros, and a Web-based visualization system was used to generate dynamic and manipulable models of the forming nephric organs. This system allows simple on-line morphometric analysis of the developing pronephric components. As in fish embryos, the glomera first form laterally then migrate medially as the pronephros matures. Unlike in the zebrafish, in Xenopus, this migration stops short of complete fusion of the two glomera at the midline, but a nephrin-positive glomeral nexus does form anteriorly and links the two structures from stage 38 onward.

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Disrupted social connectedness among Dominican women with chronic filarial lymphedema

Cited by 32 publications

References 39 publications

Stigma towards a Neglected Tropical Disease: Felt and enacted Stigma Scores among Podoconiosis Patients in Northern Ethiopia

Stigma towards a Neglected Tropical Disease: Felt and enacted Stigma Scores among Podoconiosis Patients in Northern Ethiopia

Post-Mass Drug Administration Transmission Assessment Survey for Elimination of Lymphatic Filariasis in La Ciénaga, Dominican Republic

Nephrin expression and three‐dimensional morphogenesis of the Xenopus pronephric glomus

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