Disrupted interhemispheric resting-state functional connectivity and structural connectivity in first-episode, treatment-naïve generalized anxiety disorder

Wang, Wei; Peng, Zhongmin; Wang, Xiang; Wang, Peng; Li, Qingchu; Wang, Gang; Chen, Fangni; Chen, Xinglong; Liu, Shiyuan

doi:10.1016/j.jad.2019.03.082

Cited by 18 publications

(13 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, we sought to make use of convergent and complementary measures of white matter micro-structure and homotopic functional connectivity derived from DTI and functional magnetic resonance imaging (fMRI) to assess the microstructure and function of the CC, respectively. Here, we used voxel-mirrored homotopic connectivity (VMHC) (26) to reflect inter-hemispheric functional connectivity because this approach has been widely applied to explore neural substrates underlying various mental disorders such as generalized anxiety disorder (27), seizures (28), MDD (29), and schizophrenia (30).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the brain structure-function relationship is rather complex, raising the concept that function is shaped and constrained by structure, while structure can be modified or compensated by function. Hence, investigating micro-structural and functional changes of the CC at the sub-regional level using a combination of DTI-based tractography and fMRI-based VMHC may further improve our understanding of the role of the CC in many brain disorders, such as generalized anxiety disorder (27), traumatic brain injury (34), and amyotrophic lateral sclerosis (35). However, there remains a dearth of studies of this kind in the current research realm of depression to our knowledge.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between illness duration, corpus callosum changes, and sustained attention dysfunction in major depressive disorder

Zhao¹,

Zhu²,

Zhang³

et al. 2021

Quant Imaging Med Surg

View full text Add to dashboard Cite

Background: Illness duration is the main index of cumulative illness severity during depression progression. Corpus callosum (CC) damage is among the most replicated neurobiological findings in major depressive disorder (MDD). We aimed to investigate the nature and extent of the association between illness duration and CC changes.Methods: Ninety-six MDD patients and 50 controls underwent diffusion and resting-state functional magnetic resonance imaging (fMRI). White matter micro-structure and inter-hemispheric functional connectivity were quantified by fractional anisotropy (FA) and voxel-mirrored homotopic connectivity (VMHC). The CC was reconstructed by tractography and divided into five sub-regions. The associations of illness duration with FA of each CC sub-region and voxel-wise VMHC were examined using correlation analyses. Also, we investigated the potential relationship between illness duration, CC changes, and clinical variables using mediation analyses.Results: In MDD patients, longer illness duration was selectively associated with lower FA of CC subregions 2 [partial correlation coefficient (pr) =-0.269, P=0.009] and 5 (pr=-0.296, P=0.004) as well as higher VMHC in the supplementary motor areas (pr=0.378, P<0.001), precuneus (pr=0.384, P<0.001), and lingual gyrus (pr=0.373, P<0.001) connected by the affected CC sub-regions. Further subgroup analyses demonstrated pronounced FA decrease and VMHC increase in patients with illness duration over 20 years relative to healthy controls (HC) and other patient subgroups with shorter illness durations. Moreover, lower FA of CC sub-regions 2 and 5 mediated the association between longer illness duration and more severe sustained attention dysfunction.Conclusions: These findings provide evidence for compromised structure yet compensatory function of the CC with increasing depression illness duration, which may inform effective antidepressant treatment strategies at different disease stages.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship between illness duration, corpus callosum changes, and sustained attention dysfunction in major depressive disorder

Zhao¹,

Zhu²,

Zhang³

et al. 2021

Quant Imaging Med Surg

View full text Add to dashboard Cite

show abstract

“…The corpus callosum (CC), the major white matter tract of the cerebral commissural system, plays a vital role in the structural interactions between bilateral hemispheres. Existing data confirmed that abnormalities of CC may influence interhemispheric functional communications and participate in the pathology of diseased conditions [ 8 – 10 ].…”

Section: Introductionmentioning

confidence: 84%

“…In the populations with depression, disrupted interhemispheric functional connectivity was observed within multiple brain regions, with the cognitive control network (CCN) and the default mode network (DMN) being the most commonly identified, which was correlated with clinical features in depression. Recently, disrupted homotopic functional connectivity has been observed in generalized anxiety disorder [ 8 ]. The corpus callosum (CC), the major white matter tract of the cerebral commissural system, plays a vital role in the structural interactions between bilateral hemispheres.…”

Section: Introductionmentioning

confidence: 99%

Decreased Interhemispheric Functional Connectivity and Its Associations with Clinical Correlates following Traumatic Brain Injury

Song

Han

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

Objective. To explore the interhemispheric functional coordination following traumatic brain injury (TBI) and its association with posttraumatic anxiety and depressive symptoms. Methods. This was a combination of a retrospective cohort study and a cross-sectional observational study. We investigated the functional coordination between hemispheres by voxel-mirrored homotopic connectivity (VMHC). Grey matter volumes were examined by voxel-based morphometry (VBM), and microstructural integrity of the corpus callosum (CC) was assessed by diffusion tension imaging (DTI). The anxiety and depressive symptoms were evaluated with the Hospital Anxiety and Depression Scale. Results. The VMHC values of the bilateral middle temporal gyrus (MTG) and orbital middle frontal gyrus (MFG) were significantly decreased in TBI patients versus the healthy controls. Weakened homotopic functional connectivity (FC) in the bilateral orbital MFG is moderate positively correlated with anxiety and depressive symptoms. The white matter integrity in the CC was extensively reduced in TBI patients. In the receiver operating characteristic analysis, the VMHC value of the orbital MFG could distinguish TBI from HC with an area under the curve of 0.939 (sensitivity of 1 and specificity of 0.867). Conclusion. TBI disrupts the interhemispheric functional and structural connection, which is correlated with posttraumatic mood disorders. These findings may serve as a clinical indicator for diagnosis.

show abstract

“…The FC between the bilateral hemispheres is essential, and disruption of this connectivity may be an early change in neurological pathology [23]. Alterations in interhemispheric FC have been found in some clinical trials on neurological disorders and animal studies, both in humans and in animals [24][25][26][27][28]. Voxel-mirrored homotopic connectivity (VMHC) measures the resting-state FC between each voxel in one hemisphere and its mirror counterpart in the other hemisphere [29].…”

Section: Introductionmentioning

confidence: 99%

Abnormalities of Thalamic Functional Connectivity in Patients with Migraine: A Resting-State fMRI Study

et al. 2022

View full text Add to dashboard Cite

Why carry out this study?Migraine is considered to be one of the most serious chronic dysfunctional disorders worldwide, with a high prevalence and significant loss and damage to personal health and socioeconomic well-being.The etiology of migraine is still unclear, effective treatments are lacking, and further research into its pathogenesis is urgently needed. At present, structural MRI of patients with migraine has not revealed any problems and functional MRI (fMRI) is expected to reveal biomarkers. What was learned from this study?This study used fMRI techniques to investigate the functional connectivity differences in the brain between patients with migraine and healthy controls. Compared with healthy controls, the patients exhibited abnormal voxelmirrored homotopic connectivity and functional connectivity in the bilateral thalamus. This may be related to the fact that the thalamus is an important sensory relay hub.These results provide solid evidence for the pathogenesis of migraine. In the future, studies with larger samples will be needed to further validate these findings.

show abstract

Disrupted interhemispheric resting-state functional connectivity and structural connectivity in first-episode, treatment-naïve generalized anxiety disorder

Cited by 18 publications

References 40 publications

Relationship between illness duration, corpus callosum changes, and sustained attention dysfunction in major depressive disorder

Relationship between illness duration, corpus callosum changes, and sustained attention dysfunction in major depressive disorder

Decreased Interhemispheric Functional Connectivity and Its Associations with Clinical Correlates following Traumatic Brain Injury

Abnormalities of Thalamic Functional Connectivity in Patients with Migraine: A Resting-State fMRI Study

Contact Info

Product

Resources

About