Disrupted functional connectivity of precuneus subregions in obsessive-compulsive disorder

Abstract

Highlights Heterogeneous functional connectivity alterations of precuneus in OCD. Reduced functional connectivity between dorsal posterior precuneus and vermis in OCD. Dorsal precuneus-cerebellum functional connectivity contributes to OCD pathology.

Simultaneous PET/fMRI Detects Distinctive Alterations in Functional Connectivity and Glucose Metabolism of Precuneus Subregions in Alzheimer’s Disease

“…(Khan et al, 2020). Originated from its cytoarchitecture (Cavanna and Trimble, 2006) and agreed by studies utilizing anatomical (Wang et al, 2019) and functional connectivities (Margulies et al, 2009;Ye et al, 2021) in both humans and macaques, three distinct subregions have been suggested, namely the dorsal-anterior, dorsal-posterior and ventral precuneus. Specifically, whereas DA_pcu and DP_pcu are majorly associated with sensorimotor and visual functions, V_pcu is involved in higher-order cognitive functions such as memory and self-related processing.…”

“…Despite its important role in the pathogenesis of AD as a whole cortical structure, the precuneus has been recognized as an anatomically and functionally heterogeneous brain region. Based on its cytoarchitecture as well as anatomical and functional connectivities, the precuneus has been broadly subdivided, or hieratically classified, into three clusters, namely the dorsal-anterior, dorsal-posterior, and ventral/central subregions (Margulies et al, 2009;Zhang and Li, 2012;Wang et al, 2019;Luo et al, 2020;Ye et al, 2021). Among them, the dorsal anterior and posterior subregions are majorly involved in sensorimotor and visual-related functions, and the ventral/central subregion mostly participates in higher-order cognitive and self-related functions (Cauda et al, 2010).…”

“…The use of hybrid PET/MRI technique minimizes these fluctuations in a time-efficient manner, provides better temporal and spatial registrations between the two modalities, and enables a more accurate evaluation of the interrelated functional and metabolic changes due to AD (Cecchin et al, 2017). In addition, an FC-based K-means clustering algorithm (Ye et al, 2021) was adopted to subdivide the precuneus into the dorsal-anterior, dorsal-posterior and ventral subregions. Results of this study may pave the way for further understanding of selective disruptions in subregions of the precuneus in AD.…”

Differences of regional homogeneity and cognitive function between psychotic depression and drug-naïve schizophrenia

“…The precuneus, located in the posterior superior region of the cerebral hemisphere, is a major functional area of the brain involved in various cognitive functions such as spatial perception, visual-spatial processing, memory, emotion, and consciousness [42][43][44] . In neuroscience research, the functional activity of the precuneus is frequently measured and explored, and it is also often of interest in studies of psychiatric disorders [45][46][47][48] . The activation of the precuneus is associated with the vividness of judgments during episodic memory retrieval 49 .…”

Disrupted topological properties of the structural brain network in patients with cerebellar infarction on different sides are associated with cognitive impairment

“…Available research has shown that the precuneus is involved in visuospatial processing, cognition, and consciousness, and there are functional connections between the precuneus and the frontotemporal and inferior parietal lobes ( 32 , 33 ). A study of brain functional connectivity in obsessive-compulsive disorder found key functional connections between the precuneus subregion and the cerebellum ( 34 ). The cingulate gyrus is a key node of the default network and an important part of the limbic system, which has extensive connections with the hippocampus, frontotemporal cortex, etc.…”