Disrupted functional and structural connectivity within default mode network contribute to WMH-related cognitive impairment

Chen, Xin; Huang, Lili; Ye, Qing; Yang, Dan; Qin, Ruomeng; Luo, Caimei; Li, Mengchun; Zhang, Bing; Xu, Yun

doi:10.1016/j.nicl.2019.102088

Cited by 49 publications

(56 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it should be noted that there was a significant difference both in the nocturnal systolic pressure and the diastolic pressure between OSA group and HCs group in the current study, which are common manifestations in OSA due to the interaction between nocturnal intermittent hypoxemia, hypercapnia, sleep fragmentation, neurohormonal dysregulation, and sympathetic activation (42). Recent studies demonstrated the impact of hypertension on cognitive impairment and FC alterations (43,44). The study by Li and his colleagues indicated that impaired attention and executive function existed in patients with hypertension, and furthermore, altered FC in the frontoparietal networks mediated the effects of changes of white matter on the decreased executive function in patients with hypertension (43).…”

Section: Discussion Fc Abnormality In the Hippocampal Network In Osacontrasting

confidence: 46%

“…Recent studies demonstrated the impact of hypertension on cognitive impairment and FC alterations (43,44). The study by Li and his colleagues indicated that impaired attention and executive function existed in patients with hypertension, and furthermore, altered FC in the frontoparietal networks mediated the effects of changes of white matter on the decreased executive function in patients with hypertension (43). Similarly, Carnevale et al also found that the altered FC network was associated with cognitive impairment and brain microstructural injury in patients with hypertension (44).…”

Section: Discussion Fc Abnormality In the Hippocampal Network In Osamentioning

confidence: 99%

See 1 more Smart Citation

Aberrant Hippocampal Network Connectivity Is Associated With Neurocognitive Dysfunction in Patients With Moderate and Severe Obstructive Sleep Apnea

et al. 2020

View full text Add to dashboard Cite

Objectives: This work aims to explore the changes of functional connectivity (FC) within the hippocampus network in patients with moderate and severe obstructive sleep apnea (OSA) and its correlation with neurocognitive dysfunction to explore the potential neurophysiological mechanism.Methods: A total of 32 treatment-naïve patients with moderate or severe OSA and 26 healthy controls (HCs), matched in age, gender, and education, underwent the evaluations of Epworth Sleep Scale, neurocognitive function, full-night polysomnography, and resting-state functional magnetic resonance imaging. The FC map of the hippocampus to other brain areas was compared among 15 OSA patients and 15 HCs with little head motion. Finally, the correlation between hippocampus FC strength and respiratory sleep parameters and neurocognitive assessments was analyzed.Results: Compared with HCs, the right hippocampus showed a significantly decreased FC with the bilateral insular lobe, right thalamus, and right anterior cingulate gyrus (ACG) and an increased FC with the right superior and middle temporal gyrus, left posterior cingulate gyrus, and left angular gyrus in the patients with OSA. The left hippocampus presented a significantly decreased FC with the left anterior cerebellum in patients with OSA. In addition, the aberrant right hippocampal FC with the right ACG was significantly correlated with disease severity and disrupted sleep architecture in the OSA group. Furthermore, after adjusting the related confounding factors, the FC strength between the right hippocampus, right insular lobe, and right thalamus was positively associated with the scores of Stroop Color–Word Test (SCWT) or Hopkins Verbal Learning Test—Revised (HVLT-R), while the FC between the right hippocampus and the right middle temporal gyrus was negatively correlated with the scores of HVLT-R. The right hippocampus FC with right superior temporal gyrus, left angular gyrus, and ACG were all negatively related to the scores of the symbol coding test (r = −0.642, p = 0.045; r = −0.638, p = 0.047; r = −0.753, p = 0.012), respectively. The FC between the left hippocampal and the left anterior cerebellar lobe showed a positive relationship with the scores of HVLT-R (r = 0.757, p = 0.011) and CPT-3D (r = −0.801, p = 0.005).Conclusion: The hippocampus presented abnormal FC with the cerebral and cerebellar regions extensively in OSA, and the correlation between abnormal hippocampal network FC and neurocognitive dysfunction in OSA suggests a promising insight to explore the potential biomarker and pathophysiologic mechanism of neurocognitive dysfunction of OSA.

show abstract

Section: Discussion Fc Abnormality In the Hippocampal Network In Osacontrasting

confidence: 46%

Section: Discussion Fc Abnormality In the Hippocampal Network In Osamentioning

confidence: 99%

Aberrant Hippocampal Network Connectivity Is Associated With Neurocognitive Dysfunction in Patients With Moderate and Severe Obstructive Sleep Apnea

et al. 2020

View full text Add to dashboard Cite

show abstract

“…An experienced neuropsychologist conducted all the testing. The raw scores were transformed to Z-scores for each test [30,31], which could be computed as follows:…”

Section: Neuropsychological Testingmentioning

confidence: 99%

Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment

Huang

Yang

et al. 2020

Endocrine

Self Cite

View full text Add to dashboard Cite

Purpose To identify the volume changes of hippocampus subfields in T2DM patients with cognitive impairment and to determine how these atrophy patterns associate with impairments in different cognitive domain. Methods A total of 117 individuals were recruited, including T2DM patients with cognitive impairment (T2DM-CI) (n = 34), T2DM patients without cognitive impairment (T2DM-non-CI) (n = 36) and normal controls (NC) (n = 47). All subjects went through a 3.0 T magnetic resonance (MR) scan and a neuropsychological assessment. Hippocampal subfield volumes were processed using the FreeSurfer 6.0.0 and compared among the three groups. Partial correlation analyses were used to estimate the relationship between cognitive function and hippocampal subfield volume, with age, sex, education, and eTIV (estimated total intracranial volume) as covariants. Results The total hippocampal volume had a reduction trend among the three groups, and the significantly statistical difference only was found between T2DM-CI group and NC group. Regarding the hippocampal subfields, the volumes of left subiculum, left presubiculum, left fimbria, right CA1 and right molecular layer HP decreased significantly in the T2DM-CI group (P < 0.05/12). Partial correlation analyses showed that the volumes of the left subiculum, left fimbria, and left presubiculum were significantly related to executive function. The right hippocampal CA1 volume was significantly correlated with memory in the T2DM-CI group (P < 0.05). But in T2DM-non-CI group, the correlation between the left fimbria volume and the memory, the left subiculum volume and MoCA were different with the T2DM-CI group and NC group (P < 0.05). Conclusions The smaller the volume of left presubiculum, the worse the executive function, and the atrophy of the right CA1 was related to memory impairment in T2DM-CI group. However the result was the opposite in T2DM-non-CI group. There might be a compensation mechanism of hippocampus of T2DM patients before cognitive impairment.

show abstract

“…The plasticity of fiber microstructure can be compensated temporarily, and we hypothesized that decompensation may occur with the further deterioration of patients' cognitive function, and this definitely needs to be confirmed by our follow-up studies in a larger sample. Next, structural damage may be accompanied by enhanced functional connectivity, which can enhance one's cognition (Chen et al, 2019b ). This of course needs further research including functional magnetic resonance.…”

Section: Discussionmentioning

confidence: 99%

Early Segmental White Matter Fascicle Microstructural Damage Predicts the Corresponding Cognitive Domain Impairment in Cerebral Small Vessel Disease Patients by Automated Fiber Quantification

Huang

Chen

Sun

et al. 2021

Front. Aging Neurosci.

Self Cite

View full text Add to dashboard Cite

Objective: To characterize earlier damage pattern of white matter (WM) microstructure in cerebral small vessel disease (CSVD) and its relationship with cognitive domain dysfunction.Methods: A total of 144 CSVD patients and 100 healthy controls who underwent neuropsychological measurements and diffusion tensor imaging (DTI) examination were recruited. Cognitive function, emotion, and gait were assessed in each participant. The automated fiber quantification (AFQ) technique was used to extract different fiber properties between groups, and partial correlation and general linear regression analyses were performed to assess the relationship between position-specific WM microstructure and cognitive function.Results: Specific segments in the association fibers, commissural WM regions of interest (ROIs), and projection fibers were damaged in the CSVD group [P < 0.05, family-wise error (FWE) correction], and these damaged segments showed interhemispheric symmetry. In addition, the damage to specific tract profiles [including the posteromedial component of the right cingulum cingulate (CC), the occipital lobe portion of the callosum forceps major, the posterior portion of the left superior longitudinal fasciculus (SLF), and the bilateral anterior thalamic radiation (ATR)] was related to the dysfunction in specific cognitive domains. Among these tracts, we found the ATR to be the key set of tracts whose profiles were most associated with cognitive dysfunction. The left ATR was a specific fiber bundle associated with episode memory and language function, whereas the fractional anisotropy (FA) values of the intermediate component of the right ATR were negatively correlated with executive function and gait evaluation. It should be noted that the abovementioned relationships could not survive the Bonferroni correction (p < 0.05/27), so we chose more liberal uncorrected statistical thresholds.Conclusions: Damage to the WM fiber bundles showed extensive interhemispheric symmetry and was limited to particular segments in CSVD patients. Disruption of strategically located fibers was associated with different cognitive deficits, especially the bilateral ATR.

show abstract

Disrupted functional and structural connectivity within default mode network contribute to WMH-related cognitive impairment

Abstract: HighlightDisconnective DMN contribute to impaired cognition

Cited by 49 publications

References 48 publications

Aberrant Hippocampal Network Connectivity Is Associated With Neurocognitive Dysfunction in Patients With Moderate and Severe Obstructive Sleep Apnea

Aberrant Hippocampal Network Connectivity Is Associated With Neurocognitive Dysfunction in Patients With Moderate and Severe Obstructive Sleep Apnea

Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment

Early Segmental White Matter Fascicle Microstructural Damage Predicts the Corresponding Cognitive Domain Impairment in Cerebral Small Vessel Disease Patients by Automated Fiber Quantification

Contact Info

Product

Resources

About