Disposition of trimethoprim-sulphamethoxazole combination following intrauterine administration in experimentally induced metritis condition in buffalo

Chaudhary, Sanjay; Gupta, R. C.; Uppal, R

doi:10.1016/0093-691x(87)90046-x

Cited by 4 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Зниження концентрації загального білка супроводжується зменшенням альбумінової фракції, тоді як рівень ß-і γ-глобулінової фракцій збільшується (Griga, 2007). Зменшується кількість імуноглобулінів у сироватці крові, що свідчить про пригнічення гуморальних факторів неспецифічної резистентності корів (Cobb & Watson, 1995).…”

Section: Bacterial Endometritis Of Cows and The Current Status Its Et...unclassified

“…У циклічних корів внутрішньоматкові інфузії антимікробних препаратів можуть спричинити вивільнення простагландинів, лютеоліз та позбавлення інгібуючого впливу прогестерону на захисний механізм матки (Paisley et al, 1986). Внутрішньоматкові інфузії можна вважати успішним протимікробним лікуванням ендометриту лише за умови, якщо вони викликають терапевтичні ефекти, не зважаючи на подразнення ендометрію (Chaudhery et al, 1987). Це можна вважати виправданням використання подразнюючих ендометрію внутрішньоматкових препаратів, коли користь переважає ризики (Bretzlaff, 1987).…”

Section: Bacterial Endometritis Of Cows and The Current Status Its Et...unclassified

See 1 more Smart Citation

Bacterial Endometritis of Cows and the Current Status Its Etiotropic Therapy

Muzyka,

Stetsko,

Drach

et al. 2023

SCIVP

View full text Add to dashboard Cite

In the article a literature review related to the etiology, epizootology, pathogenesis, clinical symptoms of endometritis in cows and modern means of its etiotropic therapy is provided. Postpartum endometritis is considered one of the most common diseases in cows, causing great economic losses to dairy operators, due to the increase in the number of unfertilized cows after repeated artificial insemination, the increase of the service period and the percentage of culled cows, treatment costs, decrease in milk yield, etc. The main role in the etiology of endometritis in cows in the postpartum period is assigned to bacterial opportunistic microflora. In the etiology of endometritis, the basic role is played by Staphylococcus spp., Streptococcus spp. and Escherichia coli. Other bacteria can cause endometritis in cows, such as: Actinomyces pyogenes, Fusobacterium necrophorum, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, Prevotella spp., Bacteroides spp. In many cases, acute postpartum endometritis in cows is caused by the association of microorganisms, especially Escherichia coli with streptococci and staphylococci. Microorganisms penetrate the mucous membrane of the uterus, their toxins and enzymes destroy nerve endings and capillaries, what leads to a reaction in the form of an inflammatory process, what is localized mainly in the surface layers of the endometrium and in the inter-glandular connective tissue. The development of endometritis depends on the immune response of the cow, as well as on the type and number of bacteria that colonize the endometrium. According to the kind of the inflammatory process, endometritis in cows are classified into: purulent; serous; catarrhal; serous-catarrhal; fibrinous; catarrhal-purulent. According to the passing of the disease, endometritis are acute, subacute, less often - chronic. Diagnosis of endometritis includes collection of anamnestic data, general clinical exploring of the animal and special gynecological (vaginal and rectal) testing. The basis of the treatment of endometritis in cows is etiotropic therapy, what involves by the use of antimicrobial drugs that affect the cause of the disease, and is used to stop the reproduction of opportunistic microflora in the uterine cavity and normalize the microbiocenosis. For the etiotropic therapy of endometritis in cows, drugs for intrauterine administration and drugs for systemic treatment in the form of a solution or suspension for injections are used.

show abstract

Section: Bacterial Endometritis Of Cows and The Current Status Its Et...unclassified

Bacterial Endometritis of Cows and the Current Status Its Etiotropic Therapy

Muzyka,

Stetsko,

Drach

et al. 2023

SCIVP

View full text Add to dashboard Cite

show abstract

Postpartum uterine infection in cattle

Azawi

2008

Animal Reproduction Science

170

124

View full text Add to dashboard Cite

A Study of Endometritis Causing Repeat Breeding of Cycling Iraqi Buffalo Cows

Azawi

Omran

Hadad

2008

Reprod Domestic Animals

View full text Add to dashboard Cite

The objectives of this study were to determine the non-specific aerobic and anaerobic bacterial causes of endometritis causing repeat breeding of cycling Iraqi buffalo cows at Nineveh province, validate diagnostic criteria for endometritis and to evaluate the treatment efficiency of using systemic or intra-uterine infusion of antibiotics for the treatment of endometritis. Data were collected from 60 buffalo cows with history of repeat breeding in different herds. All buffaloes were subjected to detailed clinical examination including external inspection, vaginoscopy and transrectal palpation of the cervix, uterus and ovaries. Swabs for bacteriology and biopsies for histopathology were collected from the uterine lumen from each cow. Character, odour and estimation of polymorphonuclear cells (PMN) of the vaginal mucus were scored. Blood samples were collected from cows for creatine kinase (CK) and aspartate aminotransferase (AST) measurement. Treatment conducted using oxytetracycline with tylosin in local intrauterine infusion or systemically with hormonal treatment. The most pre-disposing factor for uterine infection was retained placenta (13.3%). The most prevalent bacteria in uterine lumen were E. coli (23%), Archanobacterium pyogenes (13%) and Staphylococcus aureus (10%) were mostly isolated from buffaloes with repeat breeding. Vaginal mucus character score was associated with the bacterial growth density score. The difference in PMN was highly significant (p < 0.01) in animals with repeat breeding than control groups. In addition, PMNs was significantly (p < 0.01) correlated r = 0.894 with the character of vaginal discharge. High level of PMNs observed in buffaloes infected with A. pyogenes. Buffalo cows with endometritis had higher CK (321.47 +/- 39.06 vs 162.01 +/- 16.41 U/l) and AST (133.93 +/- 12.43 vs 97.01 +/- 6.86 U/l) activities (p < 0.05) than control-heifers, but no significant difference was observed between buffalo cows with endometritis in CK (321.47 +/- 39.06 vs 208.33 +/- 5.84) and AST (133.93 +/- 12.43 vs 156.17 +/- 9.65) activities than control-pluriparious. It could be concluded that A. pyogenes was the only non-specific uterine pathogen directly associated with severe endometrial lesions. Vaginoscopy examination combined with palpation of uterus increase the accuracy of diagnosing endometritis and cytogenic examination of uterine discharge is more reliable method of establishing the presence or absence of uterine inflammation in buffalo cows. Animals with repeat breeding (endometritis) showed clinical cure and improved pregnancy in all treatment groups with no significant difference. The use of oestradiol in repeat breeder cases has no effect in improving neither clinical cure rate nor pregnancy rate.

show abstract

Disposition of trimethoprim-sulphamethoxazole combination following intrauterine administration in experimentally induced metritis condition in buffalo

Cited by 4 publications

References 9 publications

Bacterial Endometritis of Cows and the Current Status Its Etiotropic Therapy

Bacterial Endometritis of Cows and the Current Status Its Etiotropic Therapy

Postpartum uterine infection in cattle

A Study of Endometritis Causing Repeat Breeding of Cycling Iraqi Buffalo Cows

Contact Info

Product

Resources

About