Disposable Faraday cage-type aptasensor for ultrasensitive determination of sub-picomolar Hg(II) via fast scan voltammetry

Wang, Qi; Wang, Tao; Lin, Han; Meng, Weiqiang; Zhang, Chunfeng; Cai, Pingru; Hao, Tingting; Wu, Yangbo; Guo, Zhiyong

doi:10.1016/j.snb.2020.128349

Cited by 15 publications

(5 citation statements)

References 37 publications

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“…A somewhat similar device was named “Faraday cage-type aptasensor” [ 65 ]. A screen-printed gold electrode, used as a transducer, was modified with a thymine-containing oligonucleotide using an -SH group.…”

Section: Analytes For Nucleic Acids Aptamers In the Modern Medicalmentioning

confidence: 99%

From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics

Ziółkowski

Jarczewska

Górski

et al. 2021

Sensors

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This paper focuses on the current state of art as well as on future trends in electrochemical aptasensors application in medical diagnostics. The origin of aptamers is presented along with the description of the process known as SELEX. This is followed by the description of the broad spectrum of aptamer-based sensors for the electrochemical detection of various diagnostically relevant analytes, including metal cations, abused drugs, neurotransmitters, cancer, cardiac and coagulation biomarkers, circulating tumor cells, and viruses. We described also possible future perspectives of aptasensors development. This concerns (i) the approaches to lowering the detection limit and improvement of the electrochemical aptasensors selectivity by application of the hybrid aptamer–antibody receptor layers and/or nanomaterials; and (ii) electrochemical aptasensors integration with more advanced microfluidic devices as user-friendly medical instruments for medical diagnostic of the future.

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Section: Analytes For Nucleic Acids Aptamers In the Modern Medicalmentioning

confidence: 99%

From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics

Ziółkowski

Jarczewska

Górski

et al. 2021

Sensors

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“…In this way, environmental protection agency (EPA) recommended electrochemical methods for determining the concentration of mercury in different environments as practical appealing methods. Advantages of these methods are their high sensitivity, low cost, simple operation, and portability [23,[28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Hg2+ determination by DPASV by using poly (methylene disulfide)/Au nanoparticle/MWCNT modified glassy carbon electrode by differential pulse anodic stripping voltammetry (DPASV) technique

Ghalebi,

Parham,

Shirmardi

2023

J Porous Mater

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In the present work, surface of a glassy carbon electrode (GCE) was modified by a poly (methanedisulphide)/Au-nanoparticles/multiwall carbon nanotubes (PMDS/AuNPs/MWCNT) to improve its ability for the determination of trace mercury cations in polluted water. The produced electrode was characterized with FESEM, HR-TEM, AFM, XRD, and FT-IR techniques. The obtained results proved the successfulness of the modification process and revealed that the process had a significant effect on the morphology of the electrode and its surface roughness. EIS studies demonstrated the improvement of the electrochemical properties of the surface modified sample. Accordingly, the electrical resistance to charge transfer (Rct) of the GCE-based samples decreased from 477.1 Ohm.cm 2 for the bare sample to 83.4 Ohm.cm 2 for the modified-GCE sample. The modified-GCE sample was employed as an ultra-sensitive electrode for determining the concentration of Hg 2+ cation based on DPASV technique. It exhibited linear behaviour for the concentration determination in the range of 5.98×10 -12 M to 1.00×10 -9 M with correlation coefficient of 0.996. Limit of detection (LOD) and limit of quantitation (LOQ) of the method were found 2.73×10 -13 M and 9.19×10 -13 M, respectively.

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“…Several well-established methods are currently available for detection of heavy metals in drinking water and in its source, including atomic absorption spectroscopy [ 3 , 4 ], atomic fluorescence spectroscopy [ 5 , 6 ], inductively-coupled plasma mass spectrometry [ 7 , 8 ], and gas chromatography-mass spectrometry (GC-MS) [ 9 ]. Many rapid-detection methods have been used to improve detection efficiency, including colorimetric methods based on the nucleic acids, antibodies, nanomaterials, or paper [ 10 , 11 ], fluorescence methods [ 12 , 13 ], electrochemical conduction methods [ 14 , 15 ], and recently-developed surface Raman-enhanced scattering methods [ 16 ]. Although these methods have been shown to provide high sensitivity and accuracy using biological and chemical reactions, there are some drawbacks that must still be addressed, such as difficulty in preparing nucleic acid aptamers or antibodies, low ligation efficiency, extended response time, complexity, and short lifetime.…”

Section: Introductionmentioning

confidence: 99%

A Real-Time Detection Method of Hg2+ in Drinking Water via Portable Biosensor: Using a Smartphone as a Low-Cost Micro-Spectrometer to Read the Colorimetric Signals

Jiao

Cao

et al. 2022

Biosensors

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This paper reported a real-time detection strategy for Hg2+ inspired by the visible spectrophotometer that used a smartphone as a low-cost micro-spectrometer. In combination with the smartphone’s camera and optical accessories, the phone’s built-in software can process the received light band image and then read out the spectral data in real time. The sensor was also used to detect gold nanoparticles with an LOD of 0.14 μM, which are widely used in colorimetric biosensors. Ultimately, a gold nanoparticles-glutathione (AuNPs-GSH) conjugate was used as a probe to detect Hg2+ in water with an LOD of 1.2 nM and was applied successfully to natural mineral water, pure water, tap water, and river water samples.

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Disposable Faraday cage-type aptasensor for ultrasensitive determination of sub-picomolar Hg(II) via fast scan voltammetry

Cited by 15 publications

References 37 publications

From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics

From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics

Hg2+ determination by DPASV by using poly (methylene disulfide)/Au nanoparticle/MWCNT modified glassy carbon electrode by differential pulse anodic stripping voltammetry (DPASV) technique

A Real-Time Detection Method of Hg2+ in Drinking Water via Portable Biosensor: Using a Smartphone as a Low-Cost Micro-Spectrometer to Read the Colorimetric Signals

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