Displacement of bilirubin from cord serum by sulphadimethoxine, amoxycillin, clavulanic acid in combination with either amoxycillin or ticarcillin, temocillin and cloxacillin.

Be, Davies

doi:10.1111/j.1365-2125.1985.tb05075.x

Cited by 10 publications

(3 citation statements)

References 10 publications

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“…Our results confirmed the reported location of binding sites of colchicine [19], cromolyn [20], sulphadimethoxine [21], digitoxin [17], amoxicillin [13] and ampicillin [13] in Site-I. From the other tested drugs the binding of hymecromone, butorphanol, prazosin and thioridazine to Site-I can be supposed.…”

Section: Discussionsupporting

confidence: 91%

Effect of drugs on cholesterol crystallization in an artificial bile model and relation of this effect to drug binding to albumin

Šmídková¹,

Spundová²,

Marecek

et al. 2003

Fundamemntal Clinical Pharma

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Substances that can affect the crystallization of cholesterol from human bile and consequently the gallstone formation have been given considerable attention. We improved the model system for testing cholesterol crystallization-affecting activity (promoting or inhibiting) of substances and used it for some drugs that are excreted into bile. Besides other factors natural lipid-protein complexes isolated from the native human bile have been shown to be responsible for nucleation and fast crystal growth in cholesterol supersaturated model bile. Artificial lipid-protein complex of taurolithocholate, human serum albumin and Ca2+ (TLTC-HSA-Ca2+) exhibited a lower crystallization activity than both the artificial lipid-protein complexes of taurodeoxycholate, human serum albumin and Ca2+ and the lipid-protein complex isolated from native human bile. The model bile supplemented with this artificial lipid-protein complex (TLTC-HSA-Ca2+) formed a convenient system for testing of various substances (drugs) for their crystallization-affecting activity. From the 20 tested drugs, which could occur at least in small amounts in human bile, the highest crystallization-promoting activity was found for complexes with ampicillin, butorphanol and colchicine. Complexes with tetracycline, thioridazine and doxycycline were the strongest inhibitors. The drugs, which had some effect on cholesterol crystallization, affected somehow the artificial lipid-albumin complex by displacing its components. Interactions of different drugs with HSA and its artificial complexes with the conjugated bile salt and Ca2+ ions were followed by absorption spectroscopy to observe displacement interactions. On the basis of these experiments we could classify drugs into four groups which differ by their effects on spectral characteristics of complexes.

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Section: Discussionsupporting

confidence: 91%

Effect of drugs on cholesterol crystallization in an artificial bile model and relation of this effect to drug binding to albumin

Šmídková¹,

Spundová²,

Marecek

et al. 2003

Fundamemntal Clinical Pharma

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“…Finally, it should be remembered that highly bound acidic drugs may displace bilirubin, which leads to toxic bilirubin concentrations in the brain of susceptible neonates (Davies 1985;Stem 1972).…”

Section: Neonatesmentioning

confidence: 99%

Clinical Pharmacology of the Perinatal Period and Early Infancy

Morselli¹

1989

Clinical Pharmacokinetics

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A consistent body of data, acquired in the last 20 years, indicates that at birth most of the physiological variables regulating drug kinetics are immature, thus conditioning modified kinetic profiles in the neonate. The situation may be greatly complicated by the possible 'in utero' exposure to agents capable of altering the activity of liver and/or kidney excretory functions, and/or the presence of severe pathological conditions capable of significantly altering regional or general haemodynamics. The different variables mature at different rates depending on the gestational age and physiopathological conditions.A review of the available information on drug kinetics in the neonate and early infancy is presented here. Therapeutic drug monitoring appears to be the only possible way to assure a safer therapy for at-risk populations.

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“…A variety of xenobiotics may displace or otherwise influence the binding of bilirubin to albumin. The resulting increase in the free bilirubin concentration may increase the risk of kernicterus in susceptible individuals [39,[45][46][47].…”

Section: Bilirubin In Plasmamentioning

confidence: 99%