Dispersive solid–liquid phase microextraction based on nanomagnetic Preyssler heteropolyacid: A novel method for the preconcentration of nortriptyline

Abstract

In this study, a new, simple, rapid, and efficient method combined with ultraviolet visible spectrophotometry and high-performance liquid chromatography analysis was developed for the extraction and determination of nortriptyline. The tendency of the Preyssler tungsten heteropolyacid, H14 [NaP5 W30 O110 ], immobilized on the surface of mesoporous nanomagnetite to adsorb the drug from the solution has been investigated. This method involves the use of an appropriate mixture of nanosorbent that was homogenized in disperser solvent (1.0 mL, ethanol). At first, the mixture containing the nanomagnetic sorbent and disperser solvent was injected into the aqueous sample, and a cloudy solution was formed. Subsequently, separation of the two phases was carried out using a magnet. In the second stage, analyte was desorbed from the sorbent by methanol as the optimal desorption solvent using sonication method. The elution solvent containing enriched analyte was introduced to the instruments for further analysis. Optimization of experimental conditions with respect to the extraction efficiency was investigated. The method was linear in the range of 25-5000, while the detection limit (LOD = 3SB /m) was 7.9 ng/mL and the limit of quantification (LOQ = 10SB /m) was 26.4 ng/mL. The relative standard deviation was 4.66%. The method was successfully applied to human hair samples.

New oil-in-salt liquid-phase microextraction on permutite for the extraction and concentration of alkaloids inCoptis chinensis

“…Recently, headspace single‐drop microextraction , dispersive liquid–liquid microextraction , hollow fiber LPME , hollow fiber/solvent bar microextraction , solidification of floating organic drop LPME , and ultrasound‐assisted ionic liquid based homogeneous liquid–liquid microextraction have been successfully applied to enrich and determine the trace levels of active ingredients in TCMs. Novel microextraction procedures with special salting‐out effect in different positions and neoteric extractant phase holders, such as magnetic stirrer , nanomagnetic Preyssler heteropolyacid , knitting wool , and magnetic solvent bar , were developed and applied in concentrating and determining the trace levels of target analytes in different complex samples.…”

Dendrimer-reinforced sol-gel based hollow fiber solid-phase microextraction for citalopram determination using response surface methodology

“…Separation and determination of CIT hydrobromide and its process impurities in bulk drugs and pharmaceutical formulations were developed by Rao , and CIT determination by liquid–liquid dispersive extraction was stated in some complicated samples . Besides the previously published works, there are studies on dispersive liquid–solid‐phase microextraction for preconcentration of nortriptyline , aflatoxin extraction from food samples using graphene‐based magnetic nanosorbents followed by HPLC , and SPE of benzodiazepines from hair and waste water samples using superparamagnetic nanoparticles . In this study, microextraction methods, including SPME, were considered for CIT extraction and determination.…”

Photocatalytic degradation of tetracycline aqueous solutions by nanospherical α-Fe2O3 supported on 12-tungstosilicic acid as catalyst: using full factorial experimental design

“…Thermodynamically, HPAs have stable arrangements and maintain their crystal structure in aqueous and non-aqueous solutions. This class of materials has various applications in catalysis [27], analytical chemistry [28], medicinal chemistry (anti-tumor, anti-cancer, anti-bacteria, anti-microbial and anti-clotting) [29][30][31], radioactive materials [32] and gas absorbents [33] owing to their structural diversity and unique properties. HPAs have different crystal structures of which a-, b-, c-, dand e-Keggin, Wells-Dawson, Preysler, Stromberg and Anderson-Evans are served as critical types.…”