Layperson access to the opioid overdose reversal medication naloxone can reduce mortality. 1,2 Legislation in California has allowed trained pharmacists to furnish naloxone without a physician's prescription since January 27, 2016. 3 Under a Board of Pharmacy protocol, naloxone is available by patient request or pharmacist suggestion. A furnishing pharmacist is required to screen and educate patients on opioid overdose prevention, recognition, and response.With patient consent, the pharmacist must notify the primary physician that naloxone was furnished. We estimated the availability of pharmacist-furnished naloxone 2 years after implementation.