Disorganized olfactory bulb lamination in mice deficient for transcription factor AP-2ɛ

Feng, Weiguo; Simões-de-Souza, Fábio M.; Finger, Thomas E.; Restrepo, Diego; Williams, Trevor

doi:10.1016/j.mcn.2009.06.010

Cited by 38 publications

(47 citation statements)

References 61 publications

(95 reference statements)

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“…They are often found in cell type-specific expression in either subsets of neural progenitors or postmitotic developing neurons, suggesting intrinsic roles in cell type specification, differentiation, and maintenance (Bassett et al, 2012;Feng et al, 2009;Hong et al, 2014;Kantarci et al, 2015;Pinto et al, 2009). …”

Section: Discussionmentioning

confidence: 99%

“…In this work, we exploited an AP-2ε null mouse line (Feng et al, 2009), where a Cre recombinase gene has been inserted into the endogenous AP-2ɛ genomic locus. Unlike Bcl11b null mice, AP-2ε nulls are viable with no gross structural abnormalities.…”

Section: Neurons Located Within the Apical Region Of The Vomeronasal mentioning

confidence: 99%

“…The AP-2εCre line (Tfap2e tm1(cre)Will ) were obtained from Dr. Trevor Williams, Department of Craniofacial Biology, University of Colorado, and characterized on a Black Swiss background (Feng et al, 2009 (Srinivas et al, 2001) and R26RtdTomato (B6.Cg-Gt(ROSA)26Sortm9 (CAG-tdTomato)Hze /J) (Madisen et al, 2010) were purchased from (Jackson Laboratories, Bar Harbor, ME). Lineage tracing experiments were done on littermate mice on Black Swiss/C57F3 mixed background.…”

Section: Animalsmentioning

confidence: 99%

“…By using an AP-2ε -/-(AP-2ε−null/KO) mouse line, where the Cre recombinase transgene has been knocked in the AP-2ε coding sequence (Feng et al, 2009), we could follow the expression of non-functional AP-2ε using Cre as a proxy for AP-2ε expression. In AP-…”

Section: Ap-2ε Is Expressed In Basal Vsnsmentioning

confidence: 99%

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The transcription factor Tfap2e/AP-2ε plays a pivotal role in maintaining the identity of basal vomeronasal sensory neurons

Lin

Taroc

Frías

et al. 2018

Preprint

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Highlights• The VNO contains two major cell types that are segregated in apical and basal regions of the VNO• AP-2ε is expressed in postmitotic basal vomeronasal sensory neurons.• AP-2ε is essential to maintain the identity of basal vomeronasal sensory neurons. ABSTRACTThe identity of individual neuronal cell types is defined by the expression of specific combinations of transcriptional regulators that control cell type-specific genetic programs.The epithelium of the vomeronasal organ of mice contains two major types of vomeronasal sensory neurons (VSNs): 1) the apical VSNs which express vomeronasal 1 receptors (V1r) and the G-protein subunit Gαi2 and; 2) the basal VSNs which express vomeronasal 2 receptors (V2r) and the G-protein subunit Gαo. Both cell types originate from a common pool of progenitors and eventually acquire apical or basal identity through largely unknown mechanisms.The transcription factor AP-2ε, encoded by the Tfap2e gene, plays a role in controlling the development of GABAergic interneurons in the main and accessory olfactory bulb (AOB), moreover AP-2ε has been previously described to be expressed in the VSNs.Here we show that AP-2ε is expressed in postmitotic VSNs after they commit to the basal differentiation program. Loss of AP-2ε function resulted in reduced number of basal VSNs and in an increased number of neurons expressing markers of the apical lineage. OurAll rights reserved. No reuse allowed without permission.

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Section: Discussionmentioning

confidence: 99%

Section: Neurons Located Within the Apical Region Of The Vomeronasal mentioning

confidence: 99%

Section: Animalsmentioning

confidence: 99%

Section: Ap-2ε Is Expressed In Basal Vsnsmentioning

confidence: 99%

See 2 more Smart Citations

The transcription factor Tfap2e/AP-2ε plays a pivotal role in maintaining the identity of basal vomeronasal sensory neurons

Lin

Taroc

Frías

et al. 2018

Preprint

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“…Tcfap2c knock-out mice die after gastrulation due to defective placental development (Auman et al, 2002;Werling and Schorle, 2002). The main phenotype associated with Tcfap2e knock-out mice is olfactory bulb disorganization (Feng et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

AP2 transcription factor induces apoptosis in retinoblastoma cells

Glubrecht

Godbout

2010

Genes Chromosomes & Cancer

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The underlying cause of human retinoblastoma is complete inactivation of both copies of the RB1 gene. Other chromosome abnormalities, with the most common being extra copies of chromosome arm 6p, are also observed in retinoblastoma. The RB protein has previously been shown to interact with TFAP2 transcription factors. Here, we show that TFAP2A and TFAP2B, which map to chromosome arm 6p, are expressed in the amacrine and horizontal cells of human retina. TFAP2ARNA can readily be detected in retinoblastoma cell lines and tumors; however, the great majority of retinoblastoma cell lines and tumors are completely devoid of TFAP2A protein and TFAP2B RNA/protein. Transfection of TFAP2A and TFAP2B expression constructs into retinoblastoma cells induces apoptosis and inhibits proliferation. Our results suggest that a consequence of loss of RB1 gene function in retinoblastoma cells is inactivation of TFAP2A and TFAP2B function. We propose that inability to differentiate along the amacrine/horizontal cell lineages may underlie retinoblastoma tumor formation.

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Regional differences in mitral cell development in mouse olfactory bulb

Nguyen

Imamura

2019

J of Comparative Neurology

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Olfactory sensory neurons (OSNs) located in the dorsomedial and ventromedial regions of the olfactory epithelium (OE) are distinguished from one another based on their molecular expression patterns. This difference is reflected in the separation of the glomerular layer of the olfactory bulb (OB) into dorsomedial and ventrolateral regions. However, it is unclear whether a complementary separation is also evident in the projection neurons that innervate the OB glomeruli. In this study, we compared the development of the OB between different regions by focusing on the transcription factor, Tbx21, which is expressed by mitral and tufted cells in the mature OB. Examining the OB at different developmental ages, we found that Tbx21 expression commenced in the anteromedial region called the tongue‐shaped area, followed by the dorsomedial and then ventrolateral areas. We also showed that the tongue‐shaped area was innervated by the OSNs located in the most dorsomedial part of the ventrolateral OE, the V‐zone:DM. Interestingly, the generation of OSNs occurred first in the dorsomedial zone including the V‐zone:DM, suggesting a correlation between the time course of OSN generation in the OE and Tbx21 expression in their target region of the OB. In contrast, expression of vGluT1, which is also found in all mitral cells in the mature OB, was first detected in the ventrolateral region during development. Our findings demonstrate that the development of projection neurons occurs in a compartmentalized manner in the OB; tongue‐shaped, dorsomedial, and ventrolateral areas, and that not all projection neurons follow the same developmental pathway.

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Disorganized olfactory bulb lamination in mice deficient for transcription factor AP-2ɛ

Cited by 38 publications

References 61 publications

The transcription factor Tfap2e/AP-2ε plays a pivotal role in maintaining the identity of basal vomeronasal sensory neurons

The transcription factor Tfap2e/AP-2ε plays a pivotal role in maintaining the identity of basal vomeronasal sensory neurons

AP2 transcription factor induces apoptosis in retinoblastoma cells

Regional differences in mitral cell development in mouse olfactory bulb

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