Disorders of the Sebaceous Glands

Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes

“…Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes (2,27,28). Of great importance, proliferation of SZ95 sebocytes was significantly reduced in the presence of CBD (1-10 μM) (Figure 2A).…”

A Study on the Prescribing Pattern of Drugs for Acne in a Tertiary Care Teaching Hospital in Odisha

“…seborrhea, comedogenesis, inflammation and colonization of intrafollicular duct with Propionibacterium acnes [14]. The severity of acne has been divided into 4 grades taking into account the predominant lesions present [15].…”

Soy Isoflavones Reduce Toll-like Receptor-2 Levels in Acne Vulgaris

“…Inflammation caused by peptidoglycan from P. acnes cell wall in AV lesion may activate the TLR-2 receptors in mononuclear and polymorphonuclear cells in the vicinity of the sebaceous follicle. The bond between TLR-2 and peptidoglycan will induce the production of pro-inflammatory cytokines such as IL-1, IL-8, IL-12, and TNF-α [1][2][3]. Soy isoflavoneshas anti-inflammatory effect, thus may be considered for future AV treatment, especially as the substitute for isotretinoin (13-cis retinoic acid; 13-cis RA), a systemic retinoid effective for severe acne treatment and, currently, the only drug that can induce permanent long term AV remission [1,2].…”

“…Stress was correlated with AV because it may directly or indirectly increase the sebaceous glands activities by stimulating the pituitary [1]. Sebaceous glands function was also influenced by corticotrophin-releasing hormone (CRH), which was regulated by the pituitary, thus may suffer some changes as a response to stress [1][2][3].…”

“…Acne vulgaris is a multifactorial process which has four main factors, such as excess sebum production, hypercornification of the pilosebaceous ducts, inflammation caused by the colonization of Propionibacterium acnes (P. acnes), and microcomedone caused by hyperkeratosis in the infundibulum of the pilosebaceous duct, corneocyte cohesion, and sebum secretion [1][2][3].…”