A Study on the Prescribing Pattern of Drugs for Acne in a Tertiary Care Teaching Hospital in Odisha

Patro, Nibedita; Jena, Monalisa; Panda, Maitreyee; Dash, Mrutyunjay

doi:10.7860/jcdr/2015/11634.5675

Cited by 10 publications

(16 citation statements)

References 19 publications

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“…15 In some of the studies conducted in Iraq and Odisha have shown that females were more prone to acne. 16,17 A study by Kameran also gave an evidence of the occurrence of disease mostly below 20 years of age which was very similar to our study while another study conducted in Malaysia expressed that males were affected redominantly. One difference directed from a study was that acne found to be more prevalent in urban population while it was more prevalent in rural population according to our study.…”

Section: Resultssupporting

confidence: 88%

Evaluation of Prescription Pattern and Quality of life in Acne in Tertiary Care Hospital in North Indian population

Negi¹,

Kumar²,

Kosey³

et al. 2017

RPHS

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Objective: The aim of this study was to evaluate the prescription pattern and Quality of Life of patients and severity of the disease by using Cardiff Acne Disability Index and Global Acne Grading System score respectively. Methods: A cross-sectional study was conducted in North India with 150 samples of patients included into the study. The prescription pattern comprehends the information about the prescribed drugs and also their dosing pattern for different indications that are currently being used in clinical practice. The prescription pattern varies according to the severity of the disease. Results: The cases in the study diagnosed were mostly of acne vulgaris (96.7%), followed by acne conglobata (1.3%), acne rosaceae (1.3%) and acne fulminans (0.7%). Conclusion: It was noted that oral Isotretinoin was the drug of choice for the treatment of moderate and severe forms and antibiotics included into the therapy were minocycline, clindamycin, azithromycin and erythromycin for mild and severe forms. There was not a strong degree of association between therapy and improvement in Cardiff Acne Disability Index and Global Acne Grading System but by observing overall Cardiff Acne Disability Index improvement it can be estimated that the prescription practice used for therapy enhances Quality of Life of the patient.

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Section: Resultssupporting

confidence: 88%

Evaluation of Prescription Pattern and Quality of life in Acne in Tertiary Care Hospital in North Indian population

Negi¹,

Kumar²,

Kosey³

et al. 2017

RPHS

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“…As shown in (Table 1), in the present study, 188 patients were male and 226 were females with male to female ratio 1:1.20, which is comparable with study 5 where sex ratio was 1:1.29, study 6 where sex ratio was 1:1.07, study 7 having sex ratio 1:1.33, as well with study 8 where sex ratio was 1:1.41. Above studies including this study observed higher number of female patients attending skin outpatient department for acne vulgaris.…”

Section: Gender Distributionsupporting

confidence: 86%

Study of Drug Utilization Pattern in Acne Vulgaris in Skin Outpatient Department in Tertiary Health Care Centre

Dharrao

Bhansali

2019

mvpjms

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Background: Acne vulgaris is common skin disorder which dermatologists come across in day to day practice. Drug utilization studies are very useful to explore role of drugs in the society. It involves prescription, distribution, marketing and use of drugs and its different consequences like medical and socioeconomic. Aims and Objective: To obtain information of drug prescription pattern in acne vulgaris in skin outpatient department and to evaluate pattern of prescription using World Health Organization (WHO) drug use prescribing indicators. Material and Methods: This was cross sectional observational study conducted by department of pharmacology in dermatology OPD in medical college and tertiary care centre from August 2015 to December 2017. During study period total 414 prescriptions of acne patients were analysed. Results: Out of 414 patients 226 (54.59%) were females and 188 (45.41 %) were males with male to female ratio was 1:1.20. Majority of patients belonged to 21-25 years (38.90%) followed by 15-20 (36.48%), 26-30 (18.59%), 31-35 (4.59%) and 36-40 (1.44%) with Mean age of 22.74 years. Grade II (52.66 %) consists of the majority of patients while others Grade I (35.27%), grade III (10.14%) and grade IV (1.93%). Monotherapy was prescribed in 35.26% cases and polytherapy in 64.74% cases. A total number of 950 drugs were prescribed out of them 306 (32.21%) were oral and 644 (67.79%) were topical, percentage of total fixed dose combination of topical preparations were 4%. Average number of drugs per prescription were 2.29. All drugs prescribed by prescribers are in brand names 76% (722 out of 950) of drugs were prescribed from national essential medicines list (NELM, 2015) and 19 th WHO list of essential medicines, April 2015. Conclusion: Percentage of drugs prescribed in this study from National List of Essential Medicines (NLEM) was satisfactory but shows complete use of Non-Generic (Branded) drugs. The prescription audit or the drug utilization studies can be used as further basis for the prescribers. Periodic drug audits must be conducted to reduce errors, make prescription rationalize and for effective management of acne vulgaris.

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“…4 Many drugs are available for the treatment of acne both topical and systemic i.e., antimicrobials, vitamin A analogues (retinoids; isotretinoin) and hormonal preparations. 5 Systemic antibiotics including doxycycline are used in treatment of moderate and moderate to severe acne. Oral broad spectrum antibiotics such as doxycycline and macrolides have been used in treatment of inflammatory acne.…”

mentioning

confidence: 99%

Evaluation of adapalene alone versus combination therapy of adapalene with benzoyl peroxide and adapalene with clindamycin in treatment of acne vulgaris: a prospective, observational study

et al. 2019

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Background: Acne vulgaris is majorly affecting adolescent population with profound negative impact on the quality of life (QOL). The objectives of the present study was to evaluate adapalene 0.1% alone vs combination therapy of adapalene 0.1% with benzoyl peroxide (BPO) 2.5% and adapalene 0.1% with clindamycin 1% in the treatment of acne vulgaris and to analyse health related QOL using the cardiff acne disability index (CADI).Methods: This prospective, observational study of 12 months duration involved patients who were being treated with adapalene alone and adapalene combined with either clindamycin or benzoyl peroxide in the normal course of treatment. Efficacy of treatment and QOL was assessed by the comprehensive acne severity system (CASS) and CADI respectively.Results: A total of 180 patients were enrolled (n=60 in each group). Male: female ratio was 1: 2.52. 76.7% patients were of adolescent age with the Mean age of 21.17±3.28 years. Average age of onset was 18.03±2.80 years. Most patients had moderate grade of acne (51%) followed by mild grade (46%) and almost clear (3%). Face was the common site, followed by back and chest. There was a statistically significant improvement in both number of lesions and also QOL in all the three treatment groups (p<0.0001).Conclusions: Topical adapalene 0.1% is efficacious in the treatment of acne vulgaris both alone as well as in combination with topical benzoyl peroxide 2.5% and topical clindamycin 1%. Adapalene also has positive influence on the QOL alone as well as in combination but no superiority of one group over the other was observed with regard to efficacy as well as QOL.

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A Study on the Prescribing Pattern of Drugs for Acne in a Tertiary Care Teaching Hospital in Odisha

Cited by 10 publications

References 19 publications

Evaluation of Prescription Pattern and Quality of life in Acne in Tertiary Care Hospital in North Indian population

Evaluation of Prescription Pattern and Quality of life in Acne in Tertiary Care Hospital in North Indian population

Study of Drug Utilization Pattern in Acne Vulgaris in Skin Outpatient Department in Tertiary Health Care Centre

Evaluation of adapalene alone versus combination therapy of adapalene with benzoyl peroxide and adapalene with clindamycin in treatment of acne vulgaris: a prospective, observational study

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