Disorders of iron metabolism. Part 1: molecular basis of iron homoeostasis

Múñoz, Manuel; García-Erce, José Antonio; Remacha, Ángel F.

doi:10.1136/jcp.2010.079046

Cited by 167 publications

(166 citation statements)

References 55 publications

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“…There exist some expectation that inflammatory response also significantly affects iron the status towards causing decrease in iron stores. It is also well known that inflammation interferes with iron metabolism, and erythropoiesis causing anaemia of chronic disease (ACD), also known as anaemia of inflammation, confirmed in the presence of chronic inflammation (increased CRP level in the absence of other inflammatory cause), diminished haemoglobin level and a low TSAT [10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Iron status in obese women

Stankowiak-Kulpa¹,

Kargulewicz²,

Styszynski³

et al. 2017

Ann Agric Environ Med.

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Introduction and objective. A decreased concentration of iron, and consecutively haemoglobin, ferritin and decreased level of saturated transferrin, were observed in obese individuals more often than in healthy subjects. The purpose of this study was to determine whether iron, ferritin, transferrin saturation are significantly diminished in obese female patients compared to non-obese counterparts, and whether excess adiposity and inflammation were associated with depleted iron. Materials and methods. Female patients (n=48) diagnosed with obesity (BMI > 30 kg/m

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Section: Discussionmentioning

confidence: 99%

Iron status in obese women

Stankowiak-Kulpa¹,

Kargulewicz²,

Styszynski³

et al. 2017

Ann Agric Environ Med.

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“…A normal ferritin level therefore does not exclude accompanying IDA. [7] This is evident by the reduced ferritin sensitivity of 46.4% at the clinically recommended cut-off of 30 µg/L in hospital patients. [3] More recently, automated analysers can perform tests that are reported to be independent of infection and inflammation.…”

Section: Laboratory Investigationsmentioning

confidence: 99%

Diagnosis of iron deficiency anaemia in hospital patients: Use of the reticulocyte haemoglobin content to differentiate iron deficiency anaemia from anaemia of chronic disease

2015

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“…The clinical characteristics of the patients in the current study are presented in Table I. The study protocols of CDDP-based chemotherapy and blood sampling for esophageal cancer patients (patients 1-5) and lung cancer patients (patients [6][7][8] are presented in Fig. 1 The patients received appropriate hydration and antiemetic premedication consisting of 1 mg granisetron (Granisetron intravenous solution; Meiji Seika Pharma Co., Tokyo, Japan) on day 1, 6.6 mg dexamethasone (DEXART ® injection; Fuji Pharma Co., Toyama, Japan) on day 1 and 3.3 mg dexamethasone on days 2 and 3), and 125 mg aprepitant (EMEND ® Capsule; Ono Pharmaceutical Co., Osaka, Japan) on day 1 and 80 mg aprepitant on days 2 and 3.…”

Section: Methodsmentioning

confidence: 99%

Changes in blood concentrations of trace metals in cancer patients receiving cisplatin-based chemotherapy

Nakamura¹,

Takahashi²,

Niigata³

et al. 2016

Biomedical Reports

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Abstract. The administration of cisplatin (CDDP) may influence trace metal concentrations in body fluids. In order to test this hypothesis, the blood concentrations of trace metals were determined during the present study in eight Japanese esophageal and lung cancer patients receiving CDDP-based chemotherapy. The levels of manganese, iron (Fe), cobalt, copper, zinc (Zn), platinum and lead in the plasma were determined by inductively coupled plasma-mass spectrometry. In addition, the serum levels of Fe, transferrin and ferritin were evaluated. The baseline plasma concentration of Fe in patients with esophageal cancer was significantly lower than that in lung cancer patients (P=0.011), although there were no significant differences identified with respect to the plasma levels of other trace metals. The data obtained from six fasting patients without blood transfusion demonstrated that plasma concentrations of Fe increased 3.5-fold soon after CDDP treatment and returned to baseline levels ~10 days after therapy. The excessive Fe levels in the bloodstream induced changes in serum ferritin and transferrin levels. Furthermore, serum Zn levels increased 1.8-fold in the 1-3 days following CDDP treatment, and serum cystatin C levels transiently increased. These findings indicate that serum Fe and Zn levels may be useful to understanding the physiological responses in the early stages of CDDP-based chemotherapy, which may be associated with systemic inflammation and/or tissue distribution of CDDP.

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Disorders of iron metabolism. Part 1: molecular basis of iron homoeostasis

Abstract: Iron functions Iron is an essential micronutrient, as it is required for satisfactory erythropoietic function, oxidative metabolism and cellular immune response.

Cited by 167 publications

References 55 publications

Iron status in obese women

Iron status in obese women

Diagnosis of iron deficiency anaemia in hospital patients: Use of the reticulocyte haemoglobin content to differentiate iron deficiency anaemia from anaemia of chronic disease

Changes in blood concentrations of trace metals in cancer patients receiving cisplatin-based chemotherapy

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