Disorders of Energy Balance

Lustig, Robert H.; Weiss, Ram

doi:10.1016/b978-141604090-3.50024-7

Cited by 16 publications

(20 citation statements)

References 567 publications

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“…By contrast, in patients with endocrinopathy, GV decreases and leads to short stature (1,14). However in our study, the GV of patients with ICLs was not affected, which may be misdiagnosed with exogenous obesity.…”

Section: Discussionmentioning

confidence: 99%

Intracranial Lesions in Children and Adolescents with Morbid Obesity

et al. 2017

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Background:Intracranial lesions may affect the hypothalamo-hypophyseal axis and lead to some neuro-endocrinological dysfunctions (hyperphagia, sleep disorders and hormonal dysfunctions). There is a very limited number of studies about childhood obesity and intracranial lesions.Aims:To evaluate the incidence of intracranial lesions and its role in clinical symptoms and aetiology in cases with morbid obesity who have been admitted to the paediatric endocrinology department with this complaint.Study Design:Cross-sectional study.Methods:A total of 120 cases admitted to the paediatric endocrinology department with the complaint of morbid obesity between 2002 and 2015 were included in this study. A detailed history was taken and a physical examination was performed; biochemical, hormonal parameters were evaluated. Contrast dynamic magnetic resonance imaging was performed in order to visualize cranial pathologies.Results:An intracranial lesions was detected in 16.6% of the patients and 55% of these lesions were adenoma of the hypophysis. Prolactin levels were increased in six patients but front hypophyseal hormone levels were within normal range in the rest of the patients. Growth velocity of the patients was not affected.Conclusion:In our study, the incidence of intracranial lesions in children and adolescents with morbid obesity was much higher than in the normal population. According to this data, we are of the opinion that contrast dynamic magnetic resonance imaging is helpful in children with morbid obesity for the early detection of the mass before it causes any clinical or neurological symptoms and in the prevention of future complications.

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Section: Discussionmentioning

confidence: 99%

Intracranial Lesions in Children and Adolescents with Morbid Obesity

et al. 2017

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“…to distinguish overweight and obese children, overweight (≥ 85% to < 95%) or obese (≥ 95%) according to the National Center for Health Statistics criteria. Only obese children were included in this study [16].…”

Section: Anthropometric Measurementsmentioning

confidence: 99%

“…As in adults, children areclassified as having the metabolic syndrome if they meet threeor more of the following criteria for age and gender. BMI above the 95th percentile [16], triglyceridelevel above the 95th percentile, HDL-cholesterol below the 5th percentile, systolic or diastolic blood pressure abovethe 95th percentile, impaired fasting glucose or impaired glucose tolerance (IGT) as defined by the AmericanDiabetes Association [17].Thus the objective of this study is toinvestigate the relationship of inflammatory markers and markers of endothelial dysfunction with both IR and inflammation in pre-pubertal obese children and their possible relation with metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Some Inflammatory and Endothelial Dysfunction Biomarker levels in Obese Pre-pubertal Children

Na¹,

Aa²,

Ma³

et al. 2017

IOSR JBB

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“…It is cleaved into several peptides, including adrenocorticotropic hormone (ACTH) and alpha-melanocyte-stimulating hormone (α-MSH). 19 Individuals deficient in POMC become obese due to lack of α-MSH, which, in addition to regulating melanin synthesis, inhibits food intake through binding to the MC4R. 11,17 Affected children often have a fair complexion and may present with adrenal crisis (hypoglycemia, hyponatremia, hypotension) during infancy due to ACTH deficiency.…”

Section: Monogenic Disordersmentioning

confidence: 99%

“…23 Complications from morbid obesity and renal disease are the most common causes of mortality. 2,19 …”

Section: Syndromic Disordersmentioning

confidence: 99%

Screening for Hormonal, Monogenic, and Syndromic Disorders in Obese Infants and Children

Mason¹,

Page²,

Balikcioglu³

2014

Pediatr Ann

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The prevalence of pediatric obesity in the United States is nearly 17%. Most cases are “exogenous”, resulting from excess energy intake relative to energy expenditure over a prolonged period of time. However, some cases of obesity are “endogenous”, associated with hormonal, genetic, or syndromic disorders such as hypothyroidism, Cushing’s syndrome, growth hormone deficiency, defective leptin signaling, mutations in the melanocortin 4 receptor, and Prader-Willi and Bardet-Biedl syndromes. This article reviews the hormonal, monogenic, and syndromic causes of childhood obesity and identifies critical features that distinguish “endogenous” obesity disorders from the more common exogenous obesity. Findings that raise suspicion for endogenous obesity include onset in infancy, lack of satiety, poor linear growth, dysmorphic features, and cognitive dysfunction. Selection and interpretation of appropriate laboratory tests and indications for subspecialist referral are also discussed.

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Disorders of Energy Balance

Cited by 16 publications

References 567 publications

Intracranial Lesions in Children and Adolescents with Morbid Obesity

Intracranial Lesions in Children and Adolescents with Morbid Obesity

Some Inflammatory and Endothelial Dysfunction Biomarker levels in Obese Pre-pubertal Children

Screening for Hormonal, Monogenic, and Syndromic Disorders in Obese Infants and Children

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