Intracranial Lesions in Children and Adolescents with Morbid Obesity

Ergür, Ayça Törel; Gunes, Sevinc Odabasi; Tan, Sinan; Tandircioglu, Umit Ayse

doi:10.4274/balkanmedj.2015.1541

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…We reviewed 233 hyperprolactinemic patients under 18 years of age who were followed at 32 centers. Some of these cases have been reported previously (7,8,9). Hyperprolactinemia was diagnosed when repeated PRL concentrations were above 20 ng/mL.…”

Section: Methodsmentioning

confidence: 85%

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Eren

Ergür

Isguven

et al. 2019

Jcrpe

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Objective: We aimed to report the characteristics at admission, diagnosis, treatment, and follow-up of cases of pediatric hyperprolactinemia in a large multicenter study. Methods: We reviewed the records of 233 hyperprolactinemic patients, under 18 years of age, who were followed by different centers. The patients were divided as having microadenomas, macroadenomas, drug-induced hyperprolactinemia and idiopathic hyperprolactinemia. Complaints of the patients, their mode of treatment (medication and/or surgery) and outcomes were evaluated in detail. Results: The mean age of the patients with hyperprolactinemia was 14.5 years, and 88.4% were females. In terms of etiology, microadenomas were observed in 32.6%, macroadenomas in 27%, idiopathic hyperprolactinemia in 22.7% and drug-induced hyperprolactinemia in 6.4%. Other causes of hyperprolactinemia were defined in 11.3%. Common complaints in females (n=206) were sorted into menstrual irregularities, headaches, galactorrhea, primary or secondary amenorrhea and weight gain, whereas headache, gynecomastia, short stature and blurred vision were common in males (n=27). Median prolactin levels were 93.15 ng/mL, 241.8 ng/mL, 74.5 ng/mL, 93.2 ng/mL, and 69 ng/mL for microadenomas, macroadenomas, idiopathic hyperprolactinemia, drug-induced hyperprolactinemia, and other causes of hyperprolactinemia, respectively. Of 172 patients with hyperprolactinemia, 77.3% were treated with cabergoline and 13.4% with bromocriptine. 20.1% of the patients with pituitary adenomas underwent pituitary surgery. Conclusion: We present the largest cohort of children and adolescents with hyperprolactinemia in the literature to date. Hyperprolactinemia is more common in females and cabergoline is highly effective and practical to use in adolescents, due to its biweekly dosing. Indications for surgery in pediatric cases need to be revised.

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Section: Methodsmentioning

confidence: 85%

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Eren

Ergür

Isguven

et al. 2019

Jcrpe

Self Cite

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“…A recent study by Törel Ergür et al (2017) concluded that the incidence of intracranial lesions in children and adolescents with morbid obesity was much higher than in the normal population. According to these data, contrast dynamic magnetic resonance imaging may be helpful in children with morbid obesity for the early detection of the mass before it causes any clinical or neurological symptoms, and in the prevention of future complications.…”

Section: Severe Obesity and Intracranial Lesionsmentioning

confidence: 99%

Severe paediatric obesity and sleep: A mutual interactive relationship!

Ischander

Lloyd

2020

Journal of Sleep Research

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Achieving and maintaining a healthy weight requires adequate sleep (Sekine et al., 2002;Taheri, 2006). Adequate sleep is a strong weapon for good health in general. Childhood and adolescent severe obesity are associated with serious co-morbidities, including obstructive sleep-disordered breathing (SDB), sleep disturbances, daytime sleepiness, asthma, type 2 diabetes mellitus, hypertension, dyslipidaemia, non-alcoholic fatty liver disease (NAFLD), and even premature death (Kelly et al., 2013). Children growing up in poverty have lower sleep quality and duration, which may lead to childhood obesity (Bagley, Kelly, Buckhalt, & El-Sheikh, 2015). Furthermore, adolescents are at higher risk of insufficient sleep due to a physiological delay in sleep phase plus academic and social demands (Gohil & Hannon, 2018). These childhood problems can complicate adulthood, as severe childhood obesity is associated with adulthood obesity. Additionally, the co-morbidities of severe obesity can have lasting sequelae, such as cardiovascular, metabolic and neurocognitive morbidities (Lo Bue, Salvaggio, & Insalaco, 2020) .Severe obesity was previously defined as body mass index (BMI) > 99th percentile, but more recently it has been defined as BMI ≥ 120% of the 95th percentile as class II and BMI ≥ 140% of the 95th percentile as class III obesity (Skinner, Ravanbakht, Skelton, Perrin, & Armstrong, 2018). Skinner et al. (2018) studied the prevalence of obesity and severe obesity in US children from 1999 to 2016, and reported a significant increase in severe obesity among children aged 2−5 years since the 2013-2014 cycle, a trend that continued upward for many years.

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Intracranial Lesions in Children and Adolescents with Morbid Obesity

Cited by 2 publications

References 12 publications

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Severe paediatric obesity and sleep: A mutual interactive relationship!

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