Disorders of Calcium and Phosphorus Metabolism and the Proteomics/Metabolomics-Based Research

Sun, Meiheng; Wu, Xiaoqiu; Yu, Yuanyuan; Wang, Luyao; Xie, Dizhi; Zhang, Zhenlin; Chen, Lin; Lü, Aiping; Zhang, Ge; Li, Fangfei

doi:10.3389/fcell.2020.576110

Cited by 41 publications

(42 citation statements)

References 128 publications

(154 reference statements)

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“…Calcium is the most abundant element in the body, playing a key part in cell membrane function, intracellular signaling and bone physiology [44]. Our investigation did not reveal signi cant differences in bone calcium concentrations amongst the studied groups.…”

Section: Discussioncontrasting

confidence: 44%

Impact of infrasound exposure and glucose intolerance on bone composition in Wistar rats

Zagalo¹,

Pereira²,

Casal³

et al. 2022

Preprint

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Introduction: The concentrations of some chemical elements may differ between healthy and diseased tissues. The knowledge of these differences is pivotal to understand the metabolic processes involved in both physiological and diseased states. The aim of this study was to evaluate the elemental composition of calcium (Ca) and phosphorus (P) in the bone of rats subjected to glucose intolerance and/or infrasound.Materials and Methods: X-ray fluorescence spectroscopy was applied in the concentration determination of Ca and P in samples of Wistar rat tibiae. Tibiae from glucose intolerant, non-intolerant, exposed and non-exposed to infrasound rats were analysed.Results: There was a significant decrease in bone P concentration in glucose intolerant rats compared to non-intolerant animals. Similarly, the Ca/P ratio was higher in glucose intolerant animals. There were no significant differences for bone Ca concentration in both studied groups, nor between animals exposed and non-exposed to infrasound in either studied element.Discussion and Conclusions: Glucose intolerant rats had lower bone P concentration and unaltered bone Ca concentration compared to non-glucose intolerant rats. Infrasound exposure was not associated to changes of bone Ca or P. The reduction of bone P concentration may be associated with the augmented risk of bone fractures in diabetes.

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Section: Discussioncontrasting

confidence: 44%

Impact of infrasound exposure and glucose intolerance on bone composition in Wistar rats

Zagalo¹,

Pereira²,

Casal³

et al. 2022

Preprint

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“…Ca plays also a significant role in cell signaling and biochemical processes [ 60 ]. Disruption of Ca-P homeostasis leads to skeletal and cardiovascular disorders [ 61 ]. Therefore, the intake of these nutrients should be balanced.…”

Section: Discussionmentioning

confidence: 99%

Multielemental Analysis of Bee Pollen, Propolis, and Royal Jelly Collected in West-Central Poland

Matuszewska

Klupczynska

Maciołek³

et al. 2021

Molecules

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Beehive products possess nutritional value and health-promoting properties and are recommended as so-called “superfoods”. However, because of their natural origin, they may contain relevant elemental contaminants. Therefore, to assess the quality of bee products, we examined concentrations of a broad range of 24 selected elements in propolis, bee pollen, and royal jelly. The quantitative analyses were performed with inductively coupled plasma-mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES) techniques. The results of our research indicate that bee products contain essential macronutrients (i.e., K, P, and S) and micronutrients (i.e., Zn and Fe) in concentrations depending on the products’ type. However, the presence of toxic heavy metals makes it necessary to test the quality of bee products before using them as dietary supplements. Bearing in mind that bee products are highly heterogenous and, depending on the environmental factors, differ in their elemental content, it is necessary to develop standards regulating the acceptable levels of inorganic pollutants. Furthermore, since bees and their products are considered to be an effective biomonitoring tool, our results may reflect the environment’s condition in west-central Poland, affecting the health and well-being of both humans and bees.

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“…The key parts of calcium and phosphorus metabolism are controlled by the parathyroid hormone (PTH)–1,25 dihydroxyvitamin D (1,25[OH]2D)–fibroblast growth factor-23 (FGF23) axis. 40 Magnesium deficiency can affect PTH and 1,25(OH)2D, destroy the calcium balance in the body, and lead to hypocalcemia. 41 The close relationship between them makes them important objects of research into the pathological mechanism of osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

“…Calcium, Phosphorus, and Magnesium are essential elements for the human body and play an important role in maintaining bone homeostasis. The key parts of calcium and phosphorus metabolism are controlled by the parathyroid hormone (PTH)–1,25 dihydroxyvitamin D (1,25[OH]2D)–fibroblast growth factor-23 (FGF23) axis 40 . Magnesium deficiency can affect PTH and 1,25(OH)2D, destroy the calcium balance in the body, and lead to hypocalcemia 41 .…”

Section: Discussionmentioning

confidence: 99%

Declining serum bone turnover markers are associated with the short-term positive change of lumbar spine bone mineral density in postmenopausal women

Zhao

Wen

et al. 2022

Menopause

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Objective: While serum bone turnover markers (BTMs) and bone mineral density (BMD) have been confirmed as useable risk assessment tools for postmenopausal osteoporosis, the associations between BTMs and BMD changes are still ambiguous. The aim of this study was to explore the underlying associations between BTMs and BMD changes in postmenopausal women. Methods: Between January 2015 and October 2020, 135 postmenopausal women were retrospectively enrolled. They were divided into two groups according to lumbar spine (LS) 1-4 BMD change (1 y T-score minus baseline T-score, Group 1 [ n = 36] < 0 and Group 2 [ n = 99] ≥ 0). The changes of BTMs (N-terminal middle segment osteocalcin [N-MID], propeptide of type I procollagen [P1NP], and β-C-terminal telopeptide of type I collagen [β-CTX]) and their associations with LS 1-4 BMD change were analyzed. The biochemical indices and clinical parameters related with LS 1-4 BMD change were also evaluated. Results: The 1 year N-MID, P1NP, β-CTX and Phosphorus in Group 2 were lower than those in Group 1 ( P < 0.05), their changes within 1 year were significantly negatively correlated with LS 1-4 BMD change ( R 2 = –0.200, P < 0.001; R 2 = –0.230, P < 0.001; R 2 = –0.186, P < 0.001; R 2 = –0.044, P = 0.015; respectively). Except for the Phosphorus change (area under the curve [AUC] = 0.623), the changes of N-MID, P1NP, and β-CTX and their 1 year levels had similar AUC to diagnose the short-term LS 1-4 BMD change (AUC > 0.7 for all, with the AUC of 1 y P1NP being the largest at 0.803). Binary logistic regression analysis showed that the physical activity and drug intervention were the determinant factors for the LS 1-4 BMD change (odds ratio = 6.856, 95% confidence interval: 2.058-22.839, P = 0.002; odds ratio = 5.114, 95% confidence interval: 1.551-16.864, P = 0.007; respectively). Conclusions: Declining N-MID, P1NP, β-CTX, and Phosphorus are associated with the short-term increase of LS 1-4 BMD within 1 year. Physical activity and drug intervention are factors significantly influencing the change of LS 1-4 BMD in postmenopausal women.

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Disorders of Calcium and Phosphorus Metabolism and the Proteomics/Metabolomics-Based Research

Cited by 41 publications

References 128 publications

Impact of infrasound exposure and glucose intolerance on bone composition in Wistar rats

Impact of infrasound exposure and glucose intolerance on bone composition in Wistar rats

Multielemental Analysis of Bee Pollen, Propolis, and Royal Jelly Collected in West-Central Poland

Declining serum bone turnover markers are associated with the short-term positive change of lumbar spine bone mineral density in postmenopausal women

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