Disorder-dissociated effects of fluoxetine on brain function of working memory in attention deficit hyperactivity disorder and autism spectrum disorder

Chantiluke, Kaylita; Barrett, Nadia; Giampietro, Vincent; Brammer, Michael; Simmons, Andrew; Rubia, Katya

doi:10.1017/s0033291714002232

Cited by 25 publications

(35 citation statements)

References 57 publications

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“…The present findings align with prior fMRI studies of n-back working memory that have observed altered (both increased and decreased) frontal–parietal activations in ADHD patients relative to controls ( Chantiluke et al, 2015 , Cubillo et al, 2014 , Fassbender et al, 2011 , Ko et al, 2013 , Kobel et al, 2009 , Li et al, 2014 , Silk et al, 2005 , Valera et al, 2005 , Valera et al, 2010 , Vance et al, 2007 ). Many of the prior studies observed activation differences in the absence of significantly impaired working memory performance in the ADHD patients ( Chantiluke et al, 2015 , Fassbender et al, 2011 , Ko et al, 2013 , Li et al, 2014 , Silk et al, 2005 , Valera et al, 2005 , Valera et al, 2010 , Vance et al, 2007 ). The absence of a working memory deficit in the ADHD patients in these imaging studies is in direct contradiction with many studies reporting impaired working memory in ADHD ( Burgess et al, 2010 , Gau and Shang, 2010 , Kofler et al, 2010 , Rapport et al, 2008 , Rommelse et al, 2008 , Toplak et al, 2005 ).…”

Section: Discussionsupporting

confidence: 91%

“…Studies of verbal and visuo-spatial working memory have consistently observed behavioral deficits in individuals diagnosed with ADHD ( Burgess et al, 2010 , Gau and Shang, 2010 , Kofler et al, 2010 , Rapport et al, 2008 , Rommelse et al, 2008 , Toplak et al, 2005 ). Neuroimaging studies of both visuo-spatial and verbal working memory have observed brain activation differences (both increased and decreased activation) in frontal–parietal circuits in people diagnosed with ADHD relative to typically developed controls ( Bayerl et al, 2010 , Chantiluke et al, 2015 , Cubillo et al, 2014 , Fassbender et al, 2011 , Ko et al, 2013 , Kobel et al, 2009 , Li et al, 2014 , Silk et al, 2005 , Valera et al, 2005 , Valera et al, 2010 , Vance et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

“…A paradox, however, is that multiple neuroimaging studies reporting activation differences in ADHD on working memory tasks also reported an absence of significant behavioral differences on the same tasks during the neuroimaging ( Chantiluke et al, 2015 , Fassbender et al, 2011 , Ko et al, 2013 , Li et al, 2014 , Valera et al, 2005 , Valera et al, 2010 , Vance et al, 2007 ). One possible explanation for the apparently paradoxical results concerning working memory performance and brain activation across studies is that there is a fundamental heterogeneity among ADHD patients that yields different findings depending upon the proportion of patients with impaired or intact working memory represented in any given sample.…”

Section: Introductionmentioning

confidence: 99%

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Dissociation of working memory impairments and attention-deficit/hyperactivity disorder in the brain

Mattfeld

Whitfield-Gabrieli

Biederman

et al. 2016

NeuroImage: Clinical

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Prevailing neuropsychological models of attention-deficit/hyperactivity disorder (ADHD) propose that ADHD arises from deficits in executive functions such as working memory, but accumulating clinical evidence suggests a dissociation between ADHD and executive dysfunctions. This study examined whether ADHD and working memory capacity are behaviorally and neurobiologically separable using functional magnetic resonance imaging (fMRI). Participants diagnosed with ADHD in childhood who subsequently remitted or persisted in their diagnosis as adults were characterized at follow-up in adulthood as either impaired or unimpaired in spatial working memory relative to controls who never had ADHD. ADHD participants with impaired spatial working memory performed worse than controls and ADHD participants with unimpaired working memory during an n-back working memory task while being scanned. Both controls and ADHD participants with unimpaired working memory exhibited significant linearly increasing activation in the inferior frontal junction, precuneus, lingual gyrus, and cerebellum as a function of working-memory load, and these activations did not differ significantly between these groups. ADHD participants with impaired working memory exhibited significant hypoactivation in the same regions, which was significantly different than both control participants and ADHD participants with unimpaired working memory. These findings support both a behavioral and neurobiological dissociation between ADHD and working memory capacity.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dissociation of working memory impairments and attention-deficit/hyperactivity disorder in the brain

Mattfeld

Whitfield-Gabrieli

Biederman

et al. 2016

NeuroImage: Clinical

View full text Add to dashboard Cite

show abstract

“…A total of 31 individuals (15 control and 16 ASD) also participated in our fMRI studies of sustained attention in ASD versus ADHD ( 26 ) and functional maturation of sustained attention networks in ASD versus control individuals ( 13 ). Some participants participated in other fMRI tasks during their visit, data from which are published elsewhere ( 42 , 43 , 44 , 45 ).…”

Section: Methodsmentioning

confidence: 99%

Disorder-Specific and Shared Brain Abnormalities During Vigilance in Autism and Obsessive-Compulsive Disorder

Carlisi¹,

Norman²,

Murphy

et al. 2017

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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BackgroundAutism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) are often comorbid and share similarities across some cognitive phenotypes, including certain aspects of attention. However, no functional magnetic resonance imaging studies have compared the underlying neural mechanisms contributing to these shared phenotypes.MethodsAge- and IQ-matched boys (11–17 years old) with ASD (n = 20), boys with OCD (n = 20), and healthy control boys (n = 20) performed a parametrically modulated psychomotor vigilance functional magnetic resonance imaging task. Brain activation and performance were compared among adolescents with OCD, adolescents with ASD, and control adolescents.ResultsWhereas boys with ASD and OCD were not impaired on task performance, there was a significant group by attention load interaction in several brain regions. With increasing attention load, left inferior frontal cortex/insula and left inferior parietal lobe/pre/post-central gyrus were progressively less activated in boys with OCD relative to the other two groups. In addition, boys with OCD showed progressively increased activation with increasing attention load in rostromedial prefrontal/anterior cingulate cortex relative to boys with ASD and control boys. Shared neurofunctional abnormalities between boys with ASD and boys with OCD included increased activation with increasing attention load in cerebellum and occipital regions, possibly reflecting increased default mode network activation.ConclusionsThis first functional magnetic resonance imaging study to compare boys with ASD and OCD showed shared abnormalities in posterior cerebellar–occipital brain regions. However, boys with OCD showed a disorder-specific pattern of reduced activation in left inferior frontal and temporo-parietal regions but increased activation of medial frontal regions, which may potentially be related to neurobiological mechanisms underlying cognitive and clinical phenotypes of OCD.

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“…Buspirone [95,[201][202][203], fluoxetine [204][205][206][207][208], escitalopram [209,210], citalopram [211], sertraline [212][213][214], D cycloserine [186,[215][216][217][218], amantadine [219], and memantine [220][221][222] have already been used in clinical research into autism. Finally, naltrexone, a potent opiate antagonist tested in ASD for improving behavioral changes [223][224][225][226][227][228][229][230][231][232][233][234][235][236][237][238][239], could also possess immunomodulatory action [240].…”

Section: Discussionmentioning

confidence: 99%

Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy

Marchezan

Santos

Deckmann

et al. 2018

Neuroimmunomodulation

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Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with an unknown etiology and currently few effective therapies. Immune system alterations have being demonstrated in ASD, both in humans and via animal models; immune imbalance thus arises as a possible pathway for drug intervention. In this review, the studies were classified into 2 major groups: (1) clinical research whose authors classify therapies with primary anti-inflammatory and immunomodulatory actions, making use of: sulforaphane, celecoxib, lenalidomide, pentoxifylline, spironolactone, flavonoid luteolin, corticosteroids, oral immunoglobulin, intravenous immunoglobulin, cell therapy, dialyzable lymphocyte extracts, minocycline, and pioglitazone; and (2) other ASD therapies already used or currently under study whose initial characteristics were neither anti-inflammatory nor immunomodulatory initially, but displayed a capacity for immunomodulation throughout the treatment: risperidone, vitamin D, omega-3, Ginkgo biloba, L-carnosine, N-acetylcysteine, and microbiome restoration. These studies used various data acquisition methodologies. Questions arose such the need for randomized and placebo-controlled studies with greater numbers of participants as well as the use of biomarkers to refine the treatment of autistic subjects.

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Disorder-dissociated effects of fluoxetine on brain function of working memory in attention deficit hyperactivity disorder and autism spectrum disorder

Abstract: The findings show that fluoxetine modulates brain activation during WM in a disorder-specific manner by normalizing task-positive DLPFC dysfunction in ASD boys and enhancing task-negative default mode network (DMN) deactivation in ADHD.

Cited by 25 publications

References 57 publications

Dissociation of working memory impairments and attention-deficit/hyperactivity disorder in the brain

Dissociation of working memory impairments and attention-deficit/hyperactivity disorder in the brain

Disorder-Specific and Shared Brain Abnormalities During Vigilance in Autism and Obsessive-Compulsive Disorder

Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy

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