2016
DOI: 10.1093/gerona/glw044
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Disentangling Cognitive-Frailty: Results From the Gait and Brain Study

Abstract: Combining a simple motor test, such as gait velocity, with a reliable cognitive test like the Montreal Cognitive Assessment is superior than the cognitive-frailty construct to detect individuals at risk for dementia. Cognitive-frailty may embody two different manifestations, slow gait and low cognition, of a common underlying mechanism.

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Cited by 135 publications
(127 citation statements)
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“…Even in the ‘ Gait and Brain study ’, conducted in 252 older adults free of dementia at baseline, the authors showed that those subjects displaying the combination of reduced walking speed and cognitive impairment ( n = 65, 26%) had the highest risk for progression to dementia (HR: 35.9, 95% CI: 4.0–319.2; P = 0.001, incident rate: 130/1000 person years).…”
Section: Prevalence Incidence and Clinical Impact Of The Motoric–comentioning
confidence: 99%
“…Even in the ‘ Gait and Brain study ’, conducted in 252 older adults free of dementia at baseline, the authors showed that those subjects displaying the combination of reduced walking speed and cognitive impairment ( n = 65, 26%) had the highest risk for progression to dementia (HR: 35.9, 95% CI: 4.0–319.2; P = 0.001, incident rate: 130/1000 person years).…”
Section: Prevalence Incidence and Clinical Impact Of The Motoric–comentioning
confidence: 99%
“…Design and logistics have been described in detail elsewhere [21]. Sociodemographic characteristics, comorbidities, prescribed medications, history of falls in the past 12 months, physical activity levels, and instrumental activities of daily living were collected using standardized questionnaires at all visits.…”
Section: Participant's Characteristics and Stratificationmentioning
confidence: 99%
“…Based on different combinations of these biomarkers and the decline of mental function, the cognitive frailty and various preclinical stages of AD may be recognized (Sperling et al, 2013; Ruan et al, 2015). There are a number of studies indicating that physical frailty is a risk factor of cognitive frailty, which in turn is a predictor of overall dementia, particularly vascular dementia (Giannini et al, 2015; Montero-Odasso et al, 2016; Feng et al, 2017). However, precisely how physical frailty or pre-frailty causes cognitive decline is not known (Kelaiditi et al, 2014; Panza et al, 2015; Ruan et al, 2015).…”
Section: Aging Is In the Mind—how To Change The Mind?mentioning
confidence: 99%