Diselenide-Bridged Carbon-Dot-Mediated Self-Healing, Conductive, and Adhesive Wireless Hydrogel Sensors for Label-Free Breast Cancer Detection

Won, Hyun Jeong; Ryplida, Benny; Kim, Seul Gi; Lee, Gibaek; Ryu, Ji Hyun; In, Insik

doi:10.1021/acsnano.0c02517

Cited by 102 publications

(77 citation statements)

References 55 publications

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“…Won et al combined gelatine and ureidopyriminone (Upy) into hydrogels (Gel-UPy) by performing isocyanate-amine group reactions, followed by mixing CQDs into the Gel-UPy to prepare a self- healing Gel-UPy/dsCD hydrogel. 145 The self-healing properties of the Gel-UPy/dsCD hydrogel depended on GSH and H 2 O 2 , which are produced by tumour cells rather than normal cells. As shown in Figure 8, after planting 5 pieces of Gel-UPy/dsCQD hydrogel into the cell inoculation site of mice, one hour later, the Gel-UPy/dsCQD hydrogel of the MDCK group was still a single slice, while the MDA-MB-231 group converged into a whole gel structure.…”

Section: Applications Of Cqds In Antitumour Diagnosismentioning

confidence: 98%

Recent Advances in Functional Carbon Quantum Dots for Antitumour

Cai¹,

Xiao²,

Liu³

et al. 2021

IJN

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Carbon quantum dots (CQDs) are an emerging class of quasi-zero-dimensional photoluminescent nanomaterials with particle sizes less than 10 nm. Owing to their favourable water dispersion, strong chemical inertia, stable optical performance, and good biocompatibility, CQDs have become prominent in biomedical fields. CQDs can be fabricated by "top-down" and "bottom-up" methods, both of which involve oxidation, carbonization, pyrolysis and polymerization. The functions of CQDs include biological imaging, biosensing, drug delivery, gene carrying, antimicrobial performance, photothermal ablation and so on, which enable them to be utilized in antitumour applications. The purpose of this review is to summarize the research progress of CQDs in antitumour applications from preparation and characterization to application prospects. Furthermore, the challenges and opportunities of CQDs are discussed along with future perspectives for precise individual therapy of tumours.

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Section: Applications Of Cqds In Antitumour Diagnosismentioning

confidence: 98%

Recent Advances in Functional Carbon Quantum Dots for Antitumour

Cai¹,

Xiao²,

Liu³

et al. 2021

IJN

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“…The dynamic chemical bonds primarily include the Diels–Alder reaction, [ 100–103 ] disulfide bond, [ 104–106 ] BO bond, CN bond, and CC/CS bond. The dynamic non‐covalent interactions encompass types as diverse as hydrogen bonds, [ 107–113 ] ionic interactions (metal‐coordination), [ 44,56,114–117 ] host–guest interactions, [ 118–121 ] and hydrophobic associations. [ 122,123 ]…”

Section: Stretching and Self‐healing Strategiesmentioning

confidence: 99%

“…Units of 2‐ureido‐4‐pyrimidone (UPy) that dimerize strongly in a distinctive self‐complementary array of four cooperative hydrogen bonds, schematically illustrated in Figure a, can serve as the associating end group in reversible self‐assembling polymer systems and self‐healing CHs. [ 112,138–140 ] Using the dimerized UPy pendants as cross‐linking points, a self‐healing thermoresponsive hydrogel was prepared with a tunable self‐healing ability dependent on temperature. [ 141 ] Through encapsulating the dimerization of UPy groups in hydrophobic micelles, stretchable and self‐healing hydrogels also could be synthesized.…”

Section: Stretching and Self‐healing Strategiesmentioning

confidence: 99%

Conductive Hydrogel‐Based Electrodes and Electrolytes for Stretchable and Self‐Healable Supercapacitors

Cheng

Zhang

Wang

et al. 2021

Adv Funct Materials

213

115

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Stretchable self‐healing supercapacitors (SCs) can operate under extreme deformation and restore their initial properties after damage with considerably improved durability and reliability, expanding their opportunities in numerous applications, including smart wearable electronics, bioinspired devices, human–machine interactions, etc. It is challenging, however, to achieve mechanical stretchability and self‐healability in energy storage technologies, wherein the key issue lies in the exploitation of ideal electrode and electrolyte materials with exceptional mechanical stretchability and self‐healing ability besides conductivity. Conductive hydrogels (CHs) possess unique hierarchical porous structure, high electrical/ionic conductivity, broadly tunable physical and chemical properties through molecular design and structure regulation, holding tremendous promise for stretchable self‐healing SCs. Hence, this review is innovatively constructed with a focus on stretchable and self‐healing CH based electrodes and electrolytes for SCs. First, the common synthetic approaches of CHs are introduced; then the stretching and self‐healing strategies involved in CHs are systematically elaborated; followed by an explanation of the conductive mechanism of CHs; then focusing on CH‐based electrodes and electrolytes for stretchable self‐healing SCs; subsequently, application of stretchable and self‐healing SCs in wearable electronics are discussed; finally, a conclusion is drawn along with views on the challenges and future research directions regarding the field of CHs for SCs.

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“…[62] Abnormal concentrations of Cys and GSH are significant biomarkers for many human diseases, such as liver injury, cancer, and cardiovascular disease. [63,64] Therefore, considering their important physiological roles in the human-life process, it is important to build a simple, sensitive, and efficient tool for quantitative analysis of Cys and GSH. The TMB is colorless, whereas oxTMB is blue, which provides a probe for detecting reductive biothiols molecules by fading the color of the reaction system form blue to colorless.…”

Section: Cys and Gsh Detectionmentioning

confidence: 99%

Fluorescent Hydrogel Producing ZnO for Colorimetric Detection of Glutathione and Cysteine

Kang

Tang

Gao

et al. 2021

Adv Materials Inter

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The dynamic and reversible feature of non-covalent interactions endows hydrogel specific response to external stimuli such as temperature, light, pH and oxidant, along with the macroscopic gel-sol transition. [3,[18][19][20] The properties of hydrogels can provide theoretical guidance for their application. However, hydrogels is composed of a large amounts of water and network structure. Since the presence of plenty of water, the hydrogels always have poor mechanical properties, including mechanical strength and viscoelasticity, which greatly influence the application range and the deep insight on the structure-property relationship of hydrogels. Thus, it is very urgent to design LMWGs with functional groups to develop hydrogels with prominent mechanical strength and stability for functional applications. [21][22][23][24] Among the 20 amino acids used as building blocks for proteins, the thiolcontaining amino acids, acting as antioxidants and antidotes, participate in biological activities and metabolic processes, which can retain the cellular defense against xenobiotics, gene regulation, and free radicals signal transduction. [25,26] As the only thiol-containing amino acids, cysteine (Cys) contributes biologically in human body by providing a mode for intermolecular cross-linking of proteins using the disulfide bonding to support the secondary structures and functions. [27] The quantification of Cys is important for accurate prediagnosis of its related disease such as cancer, cardiovascular and cerebrovascular disease. [28] Glutathione (GSH), a thiol-containing tripeptide (l-glutamic acid, l-cysteine, and glycine), is extensively distributed in mammalian and eukaryotic cells. [29] In the tissues, the tripeptide has two forms: reduced (GSH) and oxidized form (GSSH), which maintain the intracellular reduction-oxidation potential. [30] The intracellular level of GSH is a biomarker for various medical conditions and a disease-related physiological regulator. [31] Therefore, it is significant to detect and monitor the Cys and GSH concentration in biological samples as well as cells. Many approaches have been developed for detecting Cys and GSH, such as chromatography, spectroscopy, electrochemistry, and mass spectrometry. However, most of them required sophisticated instrumentation and tedious pretreatment, which Supramolecular hydrogels, based on non-covalent interaction, have outstanding properties, but it is still a big challenge to design hydrogels with higher mechanical properties. In this study, hydrogels with adjustable mechanical properties are prepared by mixing 4′-(4-n-butylimidazole)-pbenzyl-2,2′:6′2″-terpyridine (C 4 -Ter) and zinc ions (Zn 2+ ) in water. The hydrogels are composed of fibrous structure and hierarchical porous structure, which depends on Zn 2+ concentration. Rheological results demonstrate that the hydrogels exhibit prominent mechanical strength with the elastic modulus (G″) and yield stress (τ*) of 200 000 and 1000 Pa, respectively. X-ray diffraction and Fourier-transform infrared spectro...

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Diselenide-Bridged Carbon-Dot-Mediated Self-Healing, Conductive, and Adhesive Wireless Hydrogel Sensors for Label-Free Breast Cancer Detection

Cited by 102 publications

References 55 publications

Recent Advances in Functional Carbon Quantum Dots for Antitumour

Recent Advances in Functional Carbon Quantum Dots for Antitumour

Conductive Hydrogel‐Based Electrodes and Electrolytes for Stretchable and Self‐Healable Supercapacitors

Fluorescent Hydrogel Producing ZnO for Colorimetric Detection of Glutathione and Cysteine

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