Diseases of the skin and subcutaneous tissue

Nesterova, Anastasia P.; Klimov, Eugene; Zharkova, Maria; Sozin, Sergey; Соболев, В. В.; Ivanikova, Natalia V.; Shkrob, Maria; Yuryev, Anton

doi:10.1016/b978-0-12-817086-1.00011-7

Cited by 7 publications

(8 citation statements)

References 34 publications

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“…Moreover, cells of the same type picked from different anatomical locations also have unique active PPREs [ 45 , 46 , 47 ]. A computer analysis performed in our lab demonstrated that the transcription factor PPAR-γ is a part of a regulatory network that unites several transcription factors, namely STAT3, FOXP3, NFκB, AHR, GATA3, HIF1A, FOXO1, and FOSL1 [ 48 , 49 ]. These transcription factors regulate each other at transcriptional and post-transcriptional levels [ 12 ].…”

Section: Crosstalk Of Ppar-γ With Other Transcription Factorsmentioning

confidence: 99%

The Role of Transcription Factor PPAR-γ in the Pathogenesis of Psoriasis, Skin Cells, and Immune Cells

Соболев

Tchepourina

Korsunskaya

et al. 2022

IJMS

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The peroxisome proliferator-activated receptor PPAR-γ is one of three PPAR nuclear receptors that act as ligand-activated transcription factors. In immune cells, the skin, and other organs, PPAR-γ regulates lipid, glucose, and amino acid metabolism. The receptor translates nutritional, pharmacological, and metabolic stimuli into the changes in gene expression. The activation of PPAR-γ promotes cell differentiation, reduces the proliferation rate, and modulates the immune response. In the skin, PPARs also contribute to the functioning of the skin barrier. Since we know that the route from identification to the registration of drugs is long and expensive, PPAR-γ agonists already approved for other diseases may also represent a high interest for psoriasis. In this review, we discuss the role of PPAR-γ in the activation, differentiation, and proliferation of skin and immune cells affected by psoriasis and in contributing to the pathogenesis of the disease. We also evaluate whether the agonists of PPAR-γ may become one of the therapeutic options to suppress the inflammatory response in lesional psoriatic skin and decrease the influence of comorbidities associated with psoriasis.

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Section: Crosstalk Of Ppar-γ With Other Transcription Factorsmentioning

confidence: 99%

The Role of Transcription Factor PPAR-γ in the Pathogenesis of Psoriasis, Skin Cells, and Immune Cells

Соболев

Tchepourina

Korsunskaya

et al. 2022

IJMS

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“…These cells then stimulate the production of proinflammatory cytokines into the inflamed area. This will then enable the activation of imbalanced growth factors, cytokines (IL-1, IL-6, GM-CSF, TNF-α), and chemokines that interfere with the normal mechanism of the innate immune system of the skin ( Nesterova et al, 2019 ). Overproduction levels of cytokines will oppose the mechanism of innate immunity in the skin and consequently cause secondary bacterial infection at site of inflammation ( Albanesi and Pastore, 2010 ).…”

Section: Skin Disordersmentioning

confidence: 99%

Microalgae as Potential Anti-Inflammatory Natural Product Against Human Inflammatory Skin Diseases

et al. 2020

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The skin is the first line of defense against pathogen and other environmental pollutant. The body is constantly exposed to reactive oxygen species (ROS) that stimulates inflammatory process in the skin. Many studies have linked ROS to various inflammatory skin diseases. Patients with skin diseases face various challenges with inefficient and inappropriate treatment in managing skin diseases. Overproduction of ROS in the body will result in oxidative stress which will lead to various cellular damage and alter normal cell function. Multiple signaling pathways are seen to have significant effects during ROS-mediated oxidative stress. In this review, microalgae have been selected as a source of natural-derived antioxidant to combat inflammatory skin diseases that are prominent in today's society. Several studies have demonstrated that bioactive compounds isolated from microalgae have anti-inflammation and anti-oxidative properties that can help remedy various skin diseases. These compounds are able to inhibit production of proinflammatory cytokines and reduce the expression of inflammatory genes. Bioactive compounds from microalgae work in action by altering enzyme activities, regulating cellular activities, targeting major signaling pathways related to inflammation.

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“…Антагонисты TNF-α составляют значительную долю на мировом рынке антипсориатических препаратов [15]. ПсА и псориаз являются многофакторными воспалительными иммуноопосредованными заболеваниями с большим количеством генов, вовлеченных в сигнальные патологические процессы [16][17][18].…”

Section: Introductionunclassified

<I>TNF-α</I> gene expression in immune cells of patients with psoriasis and psoriatic arthritis

et al. 2022

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Introduction. Psoriatic disease is a heterogeneous inflammatory disease with different clinical manifestations, including plaque psoriasis and psoriatic arthritis. It has been shown that elevated levels of TNF-α are observed in both psoriatic arthritis and psoriasis. Studying the TNF-α gene expression pattern can help in the differential diagnosis between psoriatic arthritis and psoriasis.The objective is to study the TNF-α gene expression pattern in blood mononuclear cells of patients with psoriatic arthritis and psoriasis for possible differential diagnosis between these two diseases.Materials and methods. Mononuclear cells were isolated from the peripheral blood of 31 patients with plaque psoriasis, 45 patients with psoriatic arthritis and 20 healthy controls. The expression level of the TNF-α gene was analysed using a real-time PCR method.Results and discussion. As a result of the comparison, the expression level of TNF-α in patients with psoriatic arthritis was found to be 179 times higher than the expression level in healthy volunteers. The expression level of TNF-α in patients with psoriasis was also significantly (106 times) higher than the expression level in healthy people. We managed to identify a significant difference between patients with psoriatic arthritis and psoriasis.Conclusions. Patients with psoriasis in terms of TNF-α gene expression level in mononuclear cells are close to the condition of patients with psoriatic arthritis. A high level of TNF-α gene expression can become a marker of possible joint injury in patients with psoriasis and a signal to revise the therapeutic approach to a particular patient.

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Diseases of the skin and subcutaneous tissue

Cited by 7 publications

References 34 publications

The Role of Transcription Factor PPAR-γ in the Pathogenesis of Psoriasis, Skin Cells, and Immune Cells

The Role of Transcription Factor PPAR-γ in the Pathogenesis of Psoriasis, Skin Cells, and Immune Cells

Microalgae as Potential Anti-Inflammatory Natural Product Against Human Inflammatory Skin Diseases

<I>TNF-α</I> gene expression in immune cells of patients with psoriasis and psoriatic arthritis

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