Diseases of the Cornea and Sclera

Andrew, Stacy E.; Willis, A. Michelle

doi:10.1016/b0-72-160522-2/50007-8

Cited by 44 publications

(135 citation statements)

References 241 publications

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“…Corneal stromal abscesses (DSA) in horses are a significant disease process that has the potential to render a previously normal eye extremely painful and blind. This disease process consists of two major components, the corneal lesion itself, which consists of an accumulation of inflammatory cells and debris with or without and infectious agent or foreign body, and the secondary uveitis that follows the corneal insult 1–3 . Therefore, the goals of therapy in this situation are twofold.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the goals of therapy in this situation are twofold. The primary lesion must be addressed with antimicrobial medications and aggressive anti‐inflammatory therapy must be instituted for the uveitis 1–3 . It is the uveitis that results in damage to the interior structure of the eye thereby threatening the visual function of the globe.…”

Section: Introductionmentioning

confidence: 99%

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Deep lamellar endothelial keratoplasty in 10 horses

Plummer

Källberg

Ollivier

et al. 2008

Veterinary Ophthalmology

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Objective To describe and evaluate a surgical technique utilized for the therapy of deep corneal stromal abscesses (DSA) in horses. The DSA is excised and replaced with a partial thickness corneal lamellar allograft. Methods A retrospective clinical study describing the indications for the surgical technique utilized and the outcomes of this procedure in 10 eyes of 10 horses. Results Each affected eye had a discrete DSA within the posterior stroma. An initial partial thickness semicircular corneal incision was made at the limbus, followed by anterior stromal lamellar dissection over the lesion. After excision of the DSA and replacement with a larger diameter split-thickness donor button, the anterior stroma was replaced into its original position and the initial corneal incision was repaired. All of the animals that underwent deep lamellar endothelial keratoplasty (DLEK) procedure healed appropriately and with subjectively less postoperative scarring and complications than previously described surgical approaches to DSA. Conclusions This procedure is an effective technique for surgical removal of DSA in horses and, in most cases, results in a visual and cosmetically acceptable globe. The advantages of this technique compared to other surgical approaches to DSA are the peripheral location of the incision, shortened anesthesia times, the resultant minimal scarring and shorter healing times associated with DLEK.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Deep lamellar endothelial keratoplasty in 10 horses

Plummer

Källberg

Ollivier

et al. 2008

Veterinary Ophthalmology

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“…Differential considerations for the subconjunctival, episcleral mass included staphyloma, 1,2 orbital fat prolapse, 3–5 parasitic granuloma or cyst, 6,7 corneal or scleral rupture with iris prolapse, 8 ocular neoplasia (hemangioma, angiosarcoma, melanocytoma or malignant melanoma, mastocytoma, lymphosarcoma, and medulloepithelioma), 9–21 or corneal or conjunctival dermoids 8,22–26 …”

Section: Introductionmentioning

confidence: 99%

Epibulbar melanoma in a foal

McMullen¹,

Clode²,

Pandiri

et al. 2008

Veterinary Ophthalmology

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A case of epibulbar melanoma in a 6-month-old, gelded, chestnut Hanoverian foal is reported. The location and clinical appearance upon initial presentation led to the tentative diagnosis of staphyloma or a congenital mass of unknown origin. An attempt was made to surgically excise the mass under general anesthesia, but due to its infiltrative nature and intraoperative appearance, most, but not all was removed without compromising the integrity of the globe. Histopathological evaluation revealed a multinodular to packeted, poorly demarcated, unencapsulated, infiltrative exophytic melanocytic neoplasm composed of bundles and nests of plump spindloid to polygonal heavily pigmented epithelioid neoplastic cells interspersed with pigment-laden macrophages within a fine fibrovascular stroma. Upon examination after enucleation, neoplastic cells were found to infiltrate into the lateral cornea, sclera and the choroid. This is a unique case of an epibulbar melanoma with choroidal invasion in a foal. Based on the sudden onset and rapid growth as well as the histological evidence of invasion, well-differentiated features, heavy pigmentation, and no apparent mitoses, this neoplasm was considered to be a low-grade malignant melanoma. At 14 months after excision there is no evidence of recurrence.

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“…1 Secondary bacterial infection of corneal ulcers is a possible complication, developing in approximately 40% of affected horses, 2,3 with potentially devastating ocular effects such as keratomalacia, corneal perforation, endophthalmitis, or loss of the globe. 1 Secondary bacterial infection of corneal ulcers is a possible complication, developing in approximately 40% of affected horses, 2,3 with potentially devastating ocular effects such as keratomalacia, corneal perforation, endophthalmitis, or loss of the globe.…”

mentioning

confidence: 99%