Aqueous humor and plasma concentrations of ciprofloxacin and moxifloxacin following topical ocular administration in ophthalmologically normal horses

Abstract

Moxifloxacin was better able to penetrate healthy equine corneas and reach measurable AH concentrations than was ciprofloxacin, suggesting moxifloxacin might be of greater value in the treatment of deep corneal or intraocular bacterial infections caused by susceptible organisms. Topical administration of moxifloxacin also resulted in detectable plasma concentrations.

Ceratomicose em equinos

“…Os antifúngicos mais empregados são os derivados poliênicos e azólicos, que atingem os componentes da membrana celular fúngica (CLODE et al, 2010), e os análogos de nucleosídeos (MATTHEWS, 2009). Dentre os derivados poliênicos, citam-se à natamicina e a anfotericina B, e dos derivados azólicos, o miconazol (1%), itraconazol (1%) e o voriconazol (1%) (BROOKS & MATTHEWS, 2007;CLODE et al, 2010). Flucitocina é um análogo de nucleosídeo transportado através da parede celular fúngica e seu uso clínico restringe-se ao tratamento de Candida spp.…”

Achilles Tendinopathy After Treatment with Ophthalmic Moxifloxacin

“…However, a study in horses showed significant serum levels of moxifloxacin after topical administration of ophthalmic moxifloxacin, as compared to ophthalmic ciprofloxacin, which resulted in undetectable levels in the serum 8 . Risk factors associated with systemic fluoroquinolone-induced tendon disorders include age > 60 years, history of corticosteroid therapy, renal failure, diabetes mellitus, and a history of musculoskeletal disorders 9 .…”