Diseases of Infancy and Childhood

Maitra, Anirban

doi:10.1016/b978-1-4377-0792-2.50015-8

Cited by 29 publications

(52 citation statements)

References 65 publications

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“…The term hamartoma refers to an excessive, focal overgrowth of cells and tissues native to the organ in which it occurs [15] . Each component consists of mature welldifferentiated cells without atypia.…”

Section: Discussionmentioning

confidence: 99%

Multiple solid pancreatic hamartomas: A case report and review of the literature

Kawakami

Shimizu²,

Yamaguchi³

et al. 2012

WJGO

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Non-neoplastic tumor-like lesions in the pancreas are uncommon. Here, we present a case of multiple solid pancreatic hamartomas in a 78-year-old Japanese woman. Her computed tomography revealed a pancreatic mass, measuring 1.8 cm in maximum diameter. However, no symptoms were found. She was not an alcoholic and had no history of pancreatitis. The patient underwent a pancreatoduodenectomy, and three well-demarcated solid nodules measuring 1.7 cm, 0.4 cm, and 0.3 cm in diameter were found in the pancreatic head. Microscopically, the lesions were composed of non-neoplastic, disarranged acinar cells and ducts embedded in a sclerotic stroma with elongated spindle cells that lacked discrete islets. The stromal spindle cells were immunoreactive for C�34 and C�117. The histological diagnosis was multiple solid hamartomas of the pancreas. There has been no recurrence 30 mo after surgery. So far, 18 cases of pancreatic hamartoma have been reported in the English literature, including our case. Six out of these 18 cases seemed to fit the criteria of solid pancreatic hamartoma. Although the number of cases was limited, solid pancreatic hamartomas seem to be benign tumor-like lesions, which are found incidentally in healthy middle-aged adults, but occasionally involve the whole pancreas, resulting in a poor prognosis. Solid pancreatic hamartoma was sometimes associated with minor pancreatic abnormality, and multiple small lesions other than the main tumors were detected in a small number of cases. From these findings, one may speculate that solid pancreatic hamartoma could be the result of a malformation during the development of the pancreas.

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Section: Discussionmentioning

confidence: 99%

Multiple solid pancreatic hamartomas: A case report and review of the literature

Kawakami

Shimizu²,

Yamaguchi³

et al. 2012

WJGO

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“…An adequate model in such research could be neuroblastoma (NB) -the second most common solid malignancy of childhood after brain tumours, accounting for 7 -10% of all paediatric neoplasms [9]. About 40% of NBs arise in the adrenal medulla.…”

Section: Introductionmentioning

confidence: 99%

Vascular endothelial growth factor (VEGF)-C - a potent risk factor in children diagnosed with stadium 4 neuroblastoma.

Nowicki¹,

Konwerska²,

Ostalska‐Nowicka³

et al. 2009

Folia Histochem Cytobiol.

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Abstract:To evaluate the immunohistochemical expression of VEGF-C, CD34 and VEGFR-2 in cancer tissue of children diagnosed with stadium 4 neuroblastoma (NB) and correlate their presence with the survival rate of children diagnosed with that stage of the disease. Eighteen children assigned to stadium 4 composed the study group. Fourteen patients (allocated to stadium 3) formed a control group. VEGF-C, CD34 and VEGFR-2 expressions were evaluated by immunohistochemical assay. Consecutive slides incubated with anti-CD34 and anti-VEGFR-2 antibodies revealed that the two markers were colocalized within endothelial layer of the blood vessels. On the other hand, VEGF-C was expressed exclusively in tumour cells. As demonstrated by Fisher's exact test, the risk of NB treatment failure (progression or relapse) as well as tumour related death, when all the patients were considered, was found to be significant in VEGF-C positive patients. VEGF-C expression in NB constitutes a potent risk factor and may direct future anti-angiogenic treatment strategy. The proximity of VEGF-C and CD34/VEGFR-2 of NB could be the equivalent of a potentially interesting VEGF-C fashion involving a tumour cell invasion into the blood vessels in an early phase of metastases promoting.

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“…The components of the hamartoma are mature and identical to those found in the remainder of the organ, but are arranged in a disorganized fashion, with aberrant relationships to one another, so that they do not resemble the normal architecture of the tissue from which they arise." 4,15 The current case strictly follows this definition and demonstrates absence of the primitive cellular component and neoplastic characteristics, confirming the diagnosis of spinal cord hamartoma.…”

Section: Discussion Histopathologymentioning

confidence: 88%

Spinal intramedullary hamartoma with acute presentation in a 13-month old infant: case report

Samak¹,

Latif²,

Ghany³

et al. 2016

PED

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True hamartomas of the spinal cord are very rare, and although several have been reported in the literature, there are few detailed radiological and pathological descriptions of the condition. There is also considerable overlap with other entities, the most common being spinal cord teratomas. The authors report the case of a 13-month-old child with a supragluteal sacral dimple who presented with acute neurological deterioration. MRI of the spine revealed a big intramedullary lesion with heterogeneous signal intensity. A near-total resection was performed, and histopathological examination demonstrated findings consistent with a spinal cord hamartoma. The authors believe that careful preoperative evaluation and rigorous pathological examination are mandatory to establish diagnosis and direct further management of cases in which such a lesion is suspected.

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Diseases of Infancy and Childhood

Cited by 29 publications

References 65 publications

Multiple solid pancreatic hamartomas: A case report and review of the literature

Multiple solid pancreatic hamartomas: A case report and review of the literature

Vascular endothelial growth factor (VEGF)-C - a potent risk factor in children diagnosed with stadium 4 neuroblastoma.

Spinal intramedullary hamartoma with acute presentation in a 13-month old infant: case report

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