Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain

Escudero-Lara, Alejandra; Argerich, Josep; Cabañero, David

doi:10.1101/715938

Cited by 7 publications

(14 citation statements)

References 51 publications

(50 reference statements)

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“…CB2 receptors are expressed by immune cells and in the nervous system and have been co-localized with TRPV1 receptors in injured nerve fibers (Anand et al, 2008). The impact of natural and synthetic agonists of the CB1 and CB2 receptors have been explored in preclinical models of endometriosis with some promising results reported (Escudero-Lara et al, 2020;Leconte et al, 2010;Sanchez et al, 2012) (Table 4). Two trials using cannabinoid extracts to treat pain in women with endometriosis have recently been listed on ClinicalTrials.gov (NCT03875261; NCT04527003); there are no trials listed with receptor-selective agonists of the kind used in preclinical models, which is disappointing.…”

Section: Novel Therapies Targeting Endometriosis As a Pain Disordermentioning

confidence: 99%

Endometriosis: Etiology, pathobiology, and therapeutic prospects

Saunders

Horne

2021

Cell

312

305

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Section: Novel Therapies Targeting Endometriosis As a Pain Disordermentioning

confidence: 99%

Endometriosis: Etiology, pathobiology, and therapeutic prospects

Saunders

Horne

2021

Cell

312

305

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“…More recent studies show that Δ9-tetrahydrocannabinol (THC) alleviates mechanical hypersensitivity and pain in a mouse model of surgically induced endometriosis. THC also restored cognitive function and inhibited the development of endometrial cysts ( Escudero-Lara et al, 2020 ). These studies suggest CB 1 R plays a crucial role in the growth of lesions and endometriosis associated pain.…”

Section: Current Treatmentsmentioning

confidence: 99%

Pain in Endometriosis

Maddern

Grundy

Castro

et al. 2020

Front. Cell. Neurosci.

111

122

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Endometriosis is a chronic and debilitating condition affecting ∼10% of women. Endometriosis is characterized by infertility and chronic pelvic pain, yet treatment options remain limited. In many respects this is related to an underlying lack of knowledge of the etiology and mechanisms contributing to endometriosis-induced pain. Whilst many studies focus on retrograde menstruation, and the formation and development of lesions in the pathogenesis of endometriosis, the mechanisms underlying the associated pain remain poorly described. Here we review the recent clinical and experimental evidence of the mechanisms contributing to chronic pain in endometriosis. This includes the roles of inflammation, neurogenic inflammation, neuroangiogenesis, peripheral sensitization and central sensitization. As endometriosis patients are also known to have co-morbidities such as irritable bowel syndrome and overactive bladder syndrome, we highlight how common nerve pathways innervating the colon, bladder and female reproductive tract can contribute to co-morbidity via cross-organ sensitization.

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“…Apply ophthalmic ointment to avoid drying of the eyes. 4. Shave the abdomen of the mouse using an electric hair-clipper.…”

Section: Strip One Excised Uterine Horn and Open It Longitudinally Wimentioning

confidence: 99%

“…Place the uterus in a Petri dish containing cold saline solution (4 ºC, on ice) ( Figure 3C). 4. Place abdominal fat of a size similar to the uterus in another Petri dish containing cold saline solution ( Figure 3D).…”

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confidence: 99%

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Surgical Induction of Endometriosis in Female Mice

2020

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Endometriosis is a common gynecological disease characterized by the presence of endometrial tissue outside the uterine cavity. It is frequently associated with pain, infertility and a reduced quality of life, and it lacks adequate treatment. Several rodent models of endometriosis have been developed through heterologous and homologous transplantation of endometrial tissue into the abdominal compartment. Here we describe a surgical procedure to generate a syngeneic model of endometriosis in immunocompetent mice with intact uterine and ovarian tissues. In this model, four uterine fragments from a donor mouse at diestrus are sutured to the abdominal wall of a recipient mouse. One month after surgeries, endometrial implants develop into cysts with glandular epithelium and stroma, mimicking the endometriotic lesions observed in women with endometriosis. Therefore, this mouse model provides a valuable tool to study the pathophysiology of endometriosis and the efficacy of potential treatments.

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Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain

Abstract: 1 Endometriosis is a chronic painful disease highly prevalent in women that is defined by 2 growth of endometrial tissue outside the uterine cavity and lacks adequate treatment. 3

Cited by 7 publications

References 51 publications

Endometriosis: Etiology, pathobiology, and therapeutic prospects

Endometriosis: Etiology, pathobiology, and therapeutic prospects

Pain in Endometriosis

Surgical Induction of Endometriosis in Female Mice

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