Disease Closure through Opening Novel Chrono-Sciences: Bioprocessing of Intermediary Metabolism

Abstract

While deeply important, timing of nutrient intake and bioprocessing has been mostly overlooked in modern medical and nutritional sciences and public health policies. Glucose by humans is not well tolerated during evening and night times unlike morning and day time. From a chronophysiological standpoint, activity demands glucose and thus day -and not night -is the right time to bioprocess any glucose overflow [1,2]. This editorial authorizes a realistic recommendation to minimize evening and nocturnal eating and bioprocessing of especially sugars and starches to promote health through reducing risks from splanchnic and abdominal adiposity, metabolic syndrome, obesity, diabetes, hypertension, and cardiovascular abnormalities. The basis for such an advice includes the most recent discoveries on handling intermediary metabolism in sophisticated animal models.A more profound understanding of human physiology is enabled by optimal understanding of comparative animal physiology. Ruminants as sophisticated working models for studying human metabolism possess adequately integrative systems ecology, serving postmodern investigations at gene, cell, organ and whole body levels [3][4][5]. Nocturnal vs. diurnal feed delivery to dairy cows can increase intake rate and postprandial rumen release of metabolites [4][5][6]. Night feeding, also, improves milk energy production and nutrient utilization efficiency in dairy and beef ruminants [6,7]. These findings underline the biological significance of eating timing in orchestration of nutrient partitioning and metabolic health [8][9][10].The early morning glucose upsurge occurs usually in the expectation of the activity period and is called 'dawn-phenomenon'. This glucose peak along with a rise in corticosterone helps to elevate glucose supply and bioprocessing, which in turn raises insulin demands [7]. Reduced glucose tolerance overnight may partially be due to higher melatonin that basically originates from lower glucose bioprocesing capacity and needs of the night. Avoiding large evening and night food meals can allow human endocrinology to better cope with the external circadian environment towards improved nutrient bioprocessing and general health [11][12][13].The major philosophy is to help smoothly bioprocess and synchronize the internal rhythms of cell physiology with the shifting environment. Should effectively accomplished, this synchrony could largely ease brain and heart work and successfully reduce risks of metabolic disorders.In brief, animals of particularly livestock provide appropriate metabolic models for testing innovative hypotheses in human medicine and nutrition [11]. This is increasingly important as the postmodern man is facing complicated issues such as diabetes, various cancer and nervous system related diseases. Farm animals could open novel horizons into closing such rising health hurricanes. This is certainly a practical tool to bioprocess intermediary metabolism to improve health.

Circadian Timing and Regularity of Physical Activity: A Novel Bioprocess to Prevent Devastating Modern Diseases

“…The major life affairs including eating, resting, working, and exercising must accordingly possess their own optimal circadian timing that fits internal chronophysiological rhythms optimally. Recent discoveries have elaborated on the significance of circadian timing of eating on human physiology and health [1][2][3][4][5]. Optimal timing of eating in relation to exercise can also potentially and greatly improve gut health [6].…”

Scheduling Exercise-Eating to Optimize Gut Probiotics: A Global Invention

“…This has adversely affected gut physiology and health [6][7][8][9]. Notably important, timing of food intake over the circadian period has recently been a public subject of research [10][11][12][13]. For instance, evening large meals are to be avoided for those seeking optimal body fitness and overall health [5,10].…”

Crumbling the Rising Super-Cancer of Obesity by Optimizing Frequency and Timing of Food Meals

“…12 Instead, food meals must be designed and scheduled to be consumed mostly during day when the body has enough capacity to utilize and oxidize nutrients to generate energy for use by different cells. 13,14 To avoid sharp rises in insulin release and thus to reduce likelihood of insulin resistance, large and main food meals must be broken down into multiple smaller meals. Such mini-meals must be distributed over the day time from early morning through late afternoon or the latest by early evening.…”