Disease Assessment in Behçet Syndrome

Mumcu, Gonca; Yazıcı, Yusuf; Hatemi, Gülen

doi:10.1007/978-3-030-24131-5_19

Cited by 5 publications

(9 citation statements)

References 53 publications

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“…More aggressive treatments could be considered for mucocutaneous activity that could not be eliminated by non-IS medications in a limited period. 2,[11][12][13][14] These results were in accordance with the previous studies reporting that BS patients with systemic involvement were preceded by mucocutaneous manifestations, especially in younger patients. 40,41 Second, we addressed the moderational effect of age on mucocutaneous manifestations in BS.…”

Section: Discussionsupporting

confidence: 90%

“…Therefore, user‐friendly, patient‐driven activity indices are valuable tools to measure clinical progress from the BS patient’s perspective. Yet, “what to measure” and “how to measure” are critical points owing to the diversity of organ involvement in BS 4,7–11,27–31 …”

Section: Discussionmentioning

confidence: 99%

“…Yet, "what to measure" and "how to measure" are critical points owing to the diversity of organ involvement in BS. 4,[7][8][9][10][11][27][28][29][30][31] Mucocutaneous manifestations are common clinical conditions and affect the patients' lives poorly. 9,10,32,33 In the present study, validated MI as an organ-specific activity index was used to evaluate mucocutaneous activity regarding oral ulcer, genital ulcer and erythema nodosum.…”

Section: Discussionmentioning

confidence: 99%

“…The Total Activity Index, 6 Behçet’s Disease Current Activity Form (BDCAF) 7 and Behçet’s Syndrome Activity Scale 8 are validated disease‐specific PROM in BS. Oral Ulcer Severity Score, 9 Genital Ulcer Severity Score, 10 Composite Index (CI) 5 for oral ulcers and Mucocutaneous Index (MI) for mucocutaneous manifestations are validated organ‐specific PROM 2,11 …”

Section: Introductionmentioning

confidence: 99%

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Moderation analysis exploring associations between age and mucocutaneous activity in Behçet’s syndrome: A multicenter study from Turkey

Mumcu

Yay

Karaçaylı

et al. 2020

The Journal of Dermatology

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The aim of the present study was to examine the effects of age on mucocutaneous activity by using moderation analysis in Behc ßet's syndrome (BS). In this cross-sectional study, 887 BS patients (female : male, 481:406; mean age, 38.4 AE 10.9 years) followed in 13 tertiary centers in Turkey were included. Mucocutaneous activity was evaluated by using the Mucocutaneous Index (MI) according to sex and disease course. Moderation analysis was performed to test the effect of age on mucocutaneous activity. A moderator variable is a third variable and affects the relationship between independent and outcome variables. Age was chosen as a potential moderator variable (interaction effect), MI score as the outcome variable and sex as an independent variable in the analysis. The moderation analysis tested the effects of age in three steps: whole BS patient group, patients without systemic involvement and those with systemic involvement. The moderation model was only significant in BS patients with systemic involvement (P = 0.0351), and a significant relationship was observed between female sex and MI score (P = 0.0156). In addition, the interaction plot showed that female patients had increased MI scores compared with male patients, especially in the 28-year-old age group (P = 0.0067). Moreover, major organ involvement was newly diagnosed in the majority of these young female BS patients. Our results suggest that the relationship between sex and mucocutaneous activity was moderated by age in the systemic involvement group. Also, increased mucocutaneous activity may be associated with new major organ involvement in young female BS patients with systemic involvement.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Moderation analysis exploring associations between age and mucocutaneous activity in Behçet’s syndrome: A multicenter study from Turkey

Mumcu

Yay

Karaçaylı

et al. 2020

The Journal of Dermatology

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“…In fact, several systems for measurement (both scores and indexes) of patient-reported outcomes exist to better manage Behcet’s syndrome, some validate as disease-specific (Total Activity Index, Behcet’s Disease Current Activity Form, Behcet’s Syndrome Activity Scale) and other as organ-specific (Oral Ulcer Severity Score, Genital Ulcer Severity Score, Composite Index for oral ulcers and Muco-cutaneous Index) [ 72 , 73 ]. Overall, occurrence of mucocutaneous lesions (which is classically in women and decrease with advancing age) with musculoskeletal involvement represents the milder manifestation of the disease; oral ulcer activity, which is usually persistent especially in young male, and frequently precedes other organ involvement [ 66 , 67 , 68 , 72 , 73 , 74 ].…”

Section: Autoimmune and Disimmune Diseasesmentioning

confidence: 99%

Oral and Maxillo-Facial Manifestations of Systemic Diseases: An Overview

2021

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Many systemic (infective, genetic, autoimmune, neoplastic) diseases may involve the oral cavity and, more generally, the soft and hard tissues of the head and neck as primary or secondary localization. Primary onset in the oral cavity of both pediatric and adult diseases usually represents a true challenge for clinicians; their precocious detection is often difficult and requires a wide knowledge but surely results in the early diagnosis and therapy onset with an overall better prognosis and clinical outcomes. In the current paper, as for the topic of the current Special Issue, the authors present an overview on the most frequent clinical manifestations at the oral and maxillo-facial district of systemic disease.

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