Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6

Selberg, O.; Hecker, Hartmut; Martin, Michael U.; Klos, Andreas; Bautsch, Wilfried; Köhl, Jörg

doi:10.1097/00003246-200008000-00019

Cited by 210 publications

(155 citation statements)

References 28 publications

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“…In distinguishing between sepsis and noninfective causes of inflammation in children and adults, the results of our study are consistent with the literature in that the specificity of PCT was higher than that of CRP, but they differ from the literature in that the sensitivity of CRP was higher than that of PCT (14)(15)(16)(17)(18). It was found in many child and adult studies that sepsis severity was associated with PCT and IL-6 but not associated with CRP (15,17,(19)(20)(21)(22)(23)(24). The results of our study were consistent with the literature in terms of CRP, but differ from the literature in that there was no significant difference between PCT and IL-6 in distinguishing between sepsis and septic shock.…”

Section: Discussionsupporting

confidence: 74%

Role of hepcidin in the diagnosis of sepsis and septic shock in children

2018

Turk J Med Sci

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Section: Discussionsupporting

confidence: 74%

Role of hepcidin in the diagnosis of sepsis and septic shock in children

2018

Turk J Med Sci

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“…Performance of some biological markers of sepsis. 10,24,25 acute phase reactants have been described in sepsis, however none are specific enough for infection, as all can be increased in other inflammatory conditions without obvious infection (table 3).…”

Section: Strem-1: the Biological Marker Of Infection?mentioning

confidence: 99%

Soluble Form of the Triggering Receptor Expressed on Myeloid Cells-1 as a Marker of Microbial Infection

Gibot¹,

Cravoisy²

2004

Clinical Medicine & Research

117

115

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Sepsis is a common cause of morbidity and mortality in intensive care units. Unfortunately, there is no gold standard for diagnosing sepsis as clinical and laboratory signs are neither sensitive enough nor specific enough, and microbiological studies often remain negative. Thus, there is a need for clinical or laboratory tools to distinguish between sepsis and non-infectious inflammatory disorders. Among the potentially useful markers of sepsis, procalcitonin has been suggested to be the most promising, although results are variable depending on the severity of illness and degree of infection in the patient population studied. The triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily, of which expression is upregulated on phagocytic cells in the presence of bacteria or fungi. Here we report on the potential usefulness of assessing the soluble form of TREM-1 (sTREM-1) in biological fluids for the diagnosis of microbial infection.

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“…As IL-6 triggers the release of CRP in liver cells, it reacts much faster to infection than CRP [38,40]. Different cells, such as monocytes, macrophages, fibroblasts, and T2 lymphocytes, also produce IL-6 after trauma [40].…”

Section: Introductionmentioning

confidence: 99%

Novel Biomarkers to Detect Infection in Revision Hip and Knee Arthroplasties

Glehr

Friesenbichler

Hofmann

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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Background A periprosthetic joint infection is one of the most challenging complications associated with THA and TKA. In the diagnostic process for detecting a periprosthetic joint infection, one of the most important steps is analysis of laboratory infection biomarkers. Questions/purposes We investigated the sensitivity and specificity of the biomarkers procalcitonin, interleukin 6 (IL-6), and interferon a (IFN-a) as compared with conventional biomarkers (C-reactive protein [CRP], leukocyte level) for a periprosthetic joint infection associated with revision arthroplasties. Methods We prospectively included and analyzed 84 patients (124 revision arthroplasties). The blood parameters of interest were procalcitonin, IL-6, IFN-a, leukocyte level, and CRP. Samples were taken preoperatively and on the first, third, and seventh postoperative days. The sensitivity and specificity of these biomarkers then were calculated. Results Considering the preoperative values of 84 patients (124 operations), procalcitonin, IL-6, CRP, and leukocyte level correlated with periprosthetic joint infection, whereas IFN-a did not. A procalcitonin cut-off level of 0.35 ng/mL revealed a sensitivity of 80% and specificity of 37%. An IL-6 cut-off level of 2.55 pg/mL had a sensitivity of 92% and specificity of 59%. Conclusions In this study procalcitonin and IL-6 were helpful for detecting periprosthetic joint infections in revision arthroplasties, although CRP generally was superior. Procalcitonin and IL-6 may be considered adjuvant tests when the diagnosis of a periprosthetic joint infection is in doubt. This study showed, in addition to conventional biomarkers such as CRP and leukocyte level, procalcitonin and IL-6 were helpful for detecting infections associated with revision arthroplasties.

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Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6

Cited by 210 publications

References 28 publications

Role of hepcidin in the diagnosis of sepsis and septic shock in children

Role of hepcidin in the diagnosis of sepsis and septic shock in children

Soluble Form of the Triggering Receptor Expressed on Myeloid Cells-1 as a Marker of Microbial Infection

Novel Biomarkers to Detect Infection in Revision Hip and Knee Arthroplasties

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