Abstract:Human sodium-glucose cotransporter 2 (hSGLT2) is a membrane protein responsible for glucose reabsorption from the glomerular filtrate in the proximal tubule. Inhibition of hSGLT2 has been regarded as a brand new therapeutic approach for the treatment of type 2 diabetes mellitus (T2DM) due to its non-insulin related characteristics with less side effects. Current commercially available hSGLT2 inhibitors are all C-glycoside inhibitors. Previous studies have reported that N-glycoside inhibitors have better potent… Show more
Human sodium dependent glucose co-transporters (SGLTs) are the attractive targets for diabetes, and the development of SGLT1/SGLT2 dual inhibitors has received substantial attention in recent years due to their better...
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