2022
DOI: 10.3390/md20050302
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Discovery of Anti-MRSA Secondary Metabolites from a Marine-Derived Fungus Aspergillus fumigatus

Abstract: Methicillin-resistant Staphylococcus aureus (MRSA), a WHO high-priority pathogen that can cause great harm to living beings, is a primary cause of death from antibiotic-resistant infections. In the present study, six new compounds, including fumindoline A–C (1–3), 12β, 13β-hydroxy-asperfumigatin (4), 2-epi-tryptoquivaline F (17) and penibenzophenone E (37), and thirty-nine known ones were isolated from the marine-derived fungus Aspergillus fumigatus H22. The structures and the absolute configurations of the ne… Show more

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Cited by 17 publications
(8 citation statements)
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“…N -Methylated cyclic peptides, asperflomide 312 and asperflosamide 313 were isolated from A. flocculosus 140 and A. fumigatus strains were the source of a steroid 314 , a 2-oxofuranone derivative 315 , indole alkaloids 316 and 317 (as an inseparable mixture), 318 , pseurotin A derivative 319 , 141 alkaloids 320 – 324 , and penibenzophenone E 325 . 142 Gorgonian-derived Aspergillus hiratsukae strains yielded α-pyrone meroterpenoids 326 – 331 , 143 cyclic peptide 332 , ecdysteroid derivative 333 and sesquiterpene lactone 334 , 144 and nitrobenzoyl sesquiterpenoids 335 – 338 , 145 cyclohexadepsipeptides 339 , 340 (ref. 146) and sesquiterpenoids 341 , 342 – 344 (ref.…”
Section: Marine Microorganisms and Phytoplanktonmentioning
confidence: 99%
“…N -Methylated cyclic peptides, asperflomide 312 and asperflosamide 313 were isolated from A. flocculosus 140 and A. fumigatus strains were the source of a steroid 314 , a 2-oxofuranone derivative 315 , indole alkaloids 316 and 317 (as an inseparable mixture), 318 , pseurotin A derivative 319 , 141 alkaloids 320 – 324 , and penibenzophenone E 325 . 142 Gorgonian-derived Aspergillus hiratsukae strains yielded α-pyrone meroterpenoids 326 – 331 , 143 cyclic peptide 332 , ecdysteroid derivative 333 and sesquiterpene lactone 334 , 144 and nitrobenzoyl sesquiterpenoids 335 – 338 , 145 cyclohexadepsipeptides 339 , 340 (ref. 146) and sesquiterpenoids 341 , 342 – 344 (ref.…”
Section: Marine Microorganisms and Phytoplanktonmentioning
confidence: 99%
“…Compounds 66 and 68 showed potent antibacterial activity, and 69 – 74 exhibited strong anti-MRSA activity with MIC values between 1.25 and 2.5 μM. Additionally, compound 66 showed moderate inhibitory activity against Mycobacterium Bovis , with an MIC value of 25 μM, and compound 67 showed moderate inhibitory activity against C. albicans , with an MIC value of 50 μM [ 72 ].…”
Section: Aspergillus Sp From Various Marine Sources and Thei...mentioning
confidence: 99%
“…Nine antimicrobial compounds were isolated from marine fungus A. fumigatus H22. These compounds included 12,13-dihydroxyfumitremorgin C (66), fumitremorgin B (67), 13 (72), penibenzophenone E (73) and sulochrin (74) (Figure 7). Compounds 66 and 68 showed potent antibacterial activity, and 69-74 exhibited strong anti-MRSA activity with MIC values between 1.25 and 2.5 μM.…”
Section: Aspergillus Sp From Seawater and Their Antimicrobial Activitiesmentioning
confidence: 99%
“…For instance, 12β-hydroxy-13α-methoxyverruculogen TR-2, an indole diketopiperazine alkaloid, exhibited antiphytopathogenic fungi activities . Chaetomine, a quinazoline alkaloid, demonstrates significant cytotoxicity against human leukemia K562 and colon cancer SW1116 cell lines . Fumigaclavine C, an ergot alkaloid, inhibits LPS-induced NO production in RAW 264.7 cells .…”
Section: Introductionmentioning
confidence: 99%