Discovery of a DNA Topoisomerase I Inhibitor Huanglongmycin N and Its Congeners from <i>Streptomyces</i> sp. CB09001

Zhu, Saibin; Wang, Yeji; Wen, Zhongqing; Duan, Yanwen; Huang, Yong

doi:10.1021/acs.joc.1c01939

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Mirubactin ( 1 ) was first isolated from Actinosynnema mirum , 11 while its structure was later revised through total synthesis. 18,19 During our continuing search for natural products from actinomycetes, 20–23 we rediscovered 1 from Streptomyces sp. CB02460 based on its Fe( iii )-chelating property using chrome azurol S assay 24,25 and HR-ESI-MS and MS/MS analyses (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Degradation of mirubactin to multiple siderophores with varying Fe(iii) chelation properties

Jiang

Peng

et al. 2022

Org. Biomol. Chem.

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Section: Resultsmentioning

confidence: 99%

“…synthesis. 18,19 During our continuing search for natural products from actinomycetes, [20][21][22][23] we rediscovered 1 from Streptomyces sp. CB02460 based on its Fe(III)-chelating property using chrome azurol S assay 24,25 and HR-ESI-MS and MS/MS analyses (Fig.…”

Section: Introductionmentioning

confidence: 99%

Degradation of mirubactin to multiple siderophores with varying Fe(iii) chelation properties

Jiang

Peng

et al. 2022

Org. Biomol. Chem.

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Identification and application of a strong bidirectional acmN2p promoter from actinomycin D-producing streptomycetes

Li,

Tang,

Zhao

et al. 2024

Engineering Microbiology

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Overview of the New Bioactive Heterocycles as Targeting Topoisomerase Inhibitors Useful Against Colon Cancer

Santos,

de Azevedo Teotônio Cavalcanti,

de Medeiros e Silva

et al. 2024

ACAMC

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Colorectal cancer (CRC) is the third most common cancer globally, with high mortality. Metastatic CRC is incurable in most cases, and multiple drug therapy can increase patients' life expectancy by 2 to 3 years. Efforts are being made to understand the relationship between topoisomerase enzymes and colorectal cancer. Some studies have shown that higher expression of these enzymes is correlated to a poor prognosis for this type of cancer. One of the primary drugs used in the treatment of CRC is Irinotecan, which can be used in monotherapy or, more commonly, in therapeutic schemes such as FOLFIRI (Fluorouracil, Leucovorin, and Irinotecan) and CAPIRI (Capecitabine and Irinotecan). Like Camptothecin, Irinotecan and other compounds have a mechanism of action based on the formation of a ternary complex with topoisomerase I and DNA providing damage to it, therefore leading to cell death. Thus, this review focused on the principal works published in the last ten years that demonstrate a correlation between the inhibition of different isoforms of topoisomerase and in vitro cytotoxic activity against CRC by natural products, semisynthetic and synthetic compounds of pyridine, quinoline, acridine, imidazoles, indoles, and metal complexes. The results revealed that natural compounds, semisynthetic and synthetic derivatives showed potential in vitro cytotoxicity against several colon cancer cell lines, and this activity was often accompanied by the ability to inhibit both isoforms of topoisomerase (I and II), highlighting that these enzymes can be promising targets for the development of new chemotherapy against CRC. Pyridine analogs were considered the most promising for this study, while the evaluation of the real potential of natural products was limited by the lack of information in their work. Moreover, the complexes, although promising, presented as the main limitation the lack of selectivity.

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Discovery of a DNA Topoisomerase I Inhibitor Huanglongmycin N and Its Congeners from Streptomyces sp. CB09001

Cited by 3 publications

References 30 publications

Degradation of mirubactin to multiple siderophores with varying Fe(iii) chelation properties

Degradation of mirubactin to multiple siderophores with varying Fe(iii) chelation properties

Identification and application of a strong bidirectional acmN2p promoter from actinomycin D-producing streptomycetes

Overview of the New Bioactive Heterocycles as Targeting Topoisomerase Inhibitors Useful Against Colon Cancer

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