Overview of the New Bioactive Heterocycles as Targeting Topoisomerase Inhibitors
Useful Against Colon Cancer
Mirelly Barbosa Santos,
Misael de Azevedo Teotônio Cavalcanti,
Yvnni Maria Sales de Medeiros e Silva
et al.
Abstract:Colorectal cancer (CRC) is the third most common cancer globally, with high mortality. Metastatic
CRC is incurable in most cases, and multiple drug therapy can increase patients' life expectancy by 2 to 3 years.
Efforts are being made to understand the relationship between topoisomerase enzymes and colorectal cancer.
Some studies have shown that higher expression of these enzymes is correlated to a poor prognosis for this type
of cancer. One of the primary drugs used in the treatment of CRC is Irinotecan, whic… Show more
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