Discovery of a cobalt (III) salen complex that induces apoptosis in Burkitt like lymphoma and leukemia cells, overcoming multidrug resistance in vitro

Complementary and Synergistic Design of Bi‐Layered Double Hydroxides Modified Magnesium Alloy toward Multifunctional Orthopedic Implants

“…[40][41][42][43][44][45] Moreover, they possess meaningful biological functions (such as antibacterial characteristics, osteogenesis, and angiogenesis), and have interesting physicochemical properties (such as photothermal and chemodynamic effects). [46][47][48][49][50][51] Therefore, introducing Mn, Fe, and Co elements into LDH may be promising, potential LDH coatings to realize the multifunctional modification of Mg-based implants. To clearly identify the unique character-istics of each those potential LDH coatings, some basic studies must be conducted first, such as a universal and controllable LDH coatings' preparation method and systematic characterization and comparison tests.…”

A metal-free salalen ligand with anti-tumor and synergistic activity in resistant leukemia and solid tumor cells via mitochondrial pathway

“…In the case of the molybdenum complexes described by Dragoun et al ( 2018 ), the complexes did not affect the tumor cells in the same way the ligands THG 1213 and WQF 044 did (Dragoun et al 2018 ). In comparison to that, another study illustrated that a cobalt(III) salen complex had cytotoxic effects in BJAB and Nalm6 cells, but the corresponding ligand could not induce apoptosis in the tumor cells (Hopff et al 2020 ). Furthermore, ruthenium(II) complexes had cytotoxicity effects in MCF-7 and human prostate tumor cells (DU-145) in a low micromolar range, whereas their metal-free-ligand did not provoke the same outcome (Correa 2016 ).…”

“…Salans, salalens and in particular salens are most prominent ligands in coordination chemistry, and many of their metal complexes have shown potent antitumor activity (Scheme 1 , top) (Grutzke et al 2015 ; Hopff et al 2020 ; Immel et al 2011 , 2012a , b ; Lee 2010 , 2011 ; Meker et al 2011 ; Mir et al 2017 ; Peri et al 2011 ; Terenzi 2016 ). However, earlier work of ours on Mo-complexes had revealed that the biological activity may actually reside in the ligand.…”

Discovery of thirteen cobalt(ii) and copper(ii) salicylaldehyde Schiff base complexes that induce apoptosis and autophagy in human lung adenocarcinoma A549/DDP cells and that can overcome cisplatin resistance in vitro and in vivo

“…1–8 As such, they are considered valuable alternatives to Pt-based drugs. 1–8 To date, several Co- and Cu-based complexes including 4′- p -tolyl-(2,2′:6′,2′′- terpyridyl)triphenyl phosphonium bromide Cu( ii ), 1 morpholine-(iso)thiosemicarbazone Cu( ii ), 9 Cu II (thiosemi-carbazonato)Cl, 10 2-pyridylketonethiosemicarbazone Cu( ii ), 11 piperidylthiosemicarbazone Cu( ii ), 12 dasatinib Cu( ii ), 13 pyrrolizine Cu( ii ), 14 S-substituted dithiocarbazate Schiff-base Cu( ii ), 15 GSH-depleted bimetallic Cu( ii ), 16 thiosemicarbazone Cu( ii ), 17,18 carbohydrazone Cu( ii ), 19 Cu( ii ), and Co( ii ) phenanthroline, 20–25 oxygen-donor-rich-ligand Co( ii ) and Cu( ii ), 26,27 8-hydroxy-quinoline Co( iii ) and Cu( ii ), 28,29 oxoisoaporphine Co( ii ), 30 2,2′-bipyridine derivative Co( ii ) and Cu( ii ), 31–37 and tris(2-pyridylmethyl)amine-activated Co( ii ) and Cu( ii ) complexes, 38–42 among others, 43–46 have been proposed as antitumor agents that are as effective as cisplatin and its analogs. 1–8 However, none of these proposed drugs has been approved for clinical use.…”